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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection

Decourt,1,2 Noémie Jourde-Chiche,1,2 Raj Purgus,1 Charleric Bornet,5 Laurent Daniel,2,6 Valérie Moal,1,2 and Tristan Legris1 1Centre de Néphrologie et Transplantation Rénale, Hôpital Conception, Assistance

Chronic Hepatitis E Virus Infection Is Specifically Associated With an Interferon-Related Transcriptional Program

Background. Hepatitis E virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients. Clinical studies suggest that the occurrence and persistence of chronic HEV infection are related to the immunological status of patients. Methods. We used whole-genome microarray and quantitative reverse transcription polymerase chain reaction (qRT-PCR) to...

Pig Liver Sausage as a Source of Hepatitis E Virus Transmission to Humans

Background. The source and route of autochthonous hepatitis E virus (HEV) infections are not clearly established in industrialized countries despite evidence that it is a zoonosis in pigs. We investigated the role of figatellu, a traditional pig liver sausage widely eaten in France and commonly consumed raw, as a source of HEV infection. Methods. A case-control study was...

Fractalkine Expression Induces Endothelial Progenitor Cell Lysis by Natural Killer Cells

Background Circulating CD34+ cells, a population that includes endothelial progenitors, participate in the maintenance of endothelial integrity. Better understanding of the mechanisms that regulate their survival is crucial to improve their regenerative activity in cardiovascular and renal diseases. Chemokine-receptor cross talk is critical in regulating cell homeostasis. We...

Pepper Mild Mottle Virus, a Plant Virus Associated with Specific Immune Responses, Fever, Abdominal Pains, and Pruritus in Humans

Background Recently, metagenomic studies have identified viable Pepper mild mottle virus (PMMoV), a plant virus, in the stool of healthy subjects. However, its source and role as pathogen have not been determined. Methods and Findings 21 commercialized food products containing peppers, 357 stool samples from 304 adults and 208 stool samples from 137 children were tested for PMMoV...

Natural killer cell alterations correlate with loss of renal function and dialysis duration in uraemic patients

Background. Natural killer (NK) cells provide a first line of immune defence towards infections and tumours, and participate in atherosclerosis and pregnancy diseases, of which there is a higher incidence in uraemic patients. Still, their relative contribution to the immunodeficient state associated with renal failure is poorly documented. Methods. A multivariate and comparative...

Impaired expression of glycoproteins on resting and stimulated platelets in uraemic patients

Background. The increased bleeding tendency of chronic renal failure (CRF) patients has been attributed to platelet dysfunction. However, reports on various platelet functions in uraemic patients have been conflicting. The present study sought to analyse platelet function by examining their surface glycoproteins in well-identified populations of CRF patients. Methods. Three...