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Search: authors:"Valentina Escott-Price"

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No Evidence for Enrichment in Schizophrenia for Common Allelic Associations at Imprinted Loci

Most genetic studies assume that the function of a genetic variant is independent of the parent from which it is inherited, but this is not always true. The best known example of parent-of-origin effects arises with respect to alleles at imprinted loci. In classical imprinting, characteristically, either the maternal or paternal copy is expressed, but not both. Only alleles...

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

Jose Bras Rita Guerreiro Lee Darwent Laura Parkkinen Olaf Ansorge Valentina Escott-Price Dena G. Hernandez Michael A. Nalls Lorraine N. Clark Lawrence S. Honig Karen Marder Wiesje M. Van Der Flier

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide...