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Assessment of viral methylation levels for high risk HPV types by newly designed consensus primers PCR and pyrosequencing

. Formal analysis: Anna Gillio-Tos, Valentina Fiano, Chiara Grasso, Morena Trevisan, Laura De Marco, Guglielmo Ronco. 13 / 16 Funding acquisition: Guglielmo Ronco. Investigation: Valentina Fiano, Chiara ... Grasso, Morena Trevisan. Methodology: Anna Gillio-Tos, Valentina Fiano, Chiara Grasso, Morena Trevisan, Laura De Marco. Project administration: Anna Gillio-Tos, Guglielmo Ronco. Resources: Guglielmo

Subfertility and Risk of Testicular Cancer in the EPSAM Case-Control Study

Background/objectives It has been suggested that subfertility and testicular cancer share genetic and environmental risk factors. We studied both subfertility and the strongest known testicular cancer susceptibility gene, the c-KIT ligand (KITLG), whose pathway is involved in spermatogenesis. Methods The EPSAM case-control study is comprised of testicular cancer patients from the...

Performance of Different Analytical Software Packages in Quantification of DNA Methylation by Pyrosequencing

Background Pyrosequencing has emerged as an alternative method of nucleic acid sequencing, well suited for many applications which aim to characterize single nucleotide polymorphisms, mutations, microbial types and CpG methylation in the target DNA. The commercially available pyrosequencing systems can harbor two different types of software which allow analysis in AQ or CpG mode...

Methylation of APC and GSTP1 in Non-Neoplastic Tissue Adjacent to Prostate Tumour and Mortality from Prostate Cancer

Background Markers that can discriminate between indolent and aggressive prostate tumours are needed. We studied gene methylation in non-neoplastic tissue adjacent to prostate tumour (NTAT) in association with prostate cancer mortality. Methods From two cohorts of consecutive prostate cancer patients diagnosed at one pathology ward in Turin, Italy, we selected 157 patients with...

Seasonality Modifies Methylation Profiles in Healthy People

DNA methylation is a well-characterized epigenetic modification that plays an important role in the regulation of gene expression. There is growing evidence on the involvement of epigenetic mechanisms in disease onset, including cancer. Environmental factors seem to induce changes in DNA methylation affecting human health. However, little is known about basal methylation levels...

Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis

Background The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hypotheses. The tolerogenic protein HLA-G has shown aberrant...

Occult HCV Infection: An Unexpected Finding in a Population Unselected for Hepatic Disease

Background Occult Hepatitis C virus (HCV) infection is a new pathological entity characterized by presence of liver disease and absence or very low levels of detectable HCV-RNA in serum. Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a...

Piccolipiù, a multicenter birth cohort in Italy: protocol of the study

Background The fetal and infant life are periods of rapid development, characterized by high susceptibility to exposures. Birth cohorts provide unique opportunities to study early-life exposures in association with child development and health, as well as, with longer follow-up, the early life origin of adult diseases. Piccolipiù is an Italian birth cohort recently set up to...