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Europäische Datensammlung zur Präimplantationsdiagnostik seit 1999

Seit 25 Jahren gibt es die Präimplantationsdiagnostik (PID) als Alternative zur Pränataldiagnostik monogener, mitochondrialer und chromosomaler Erkrankungen. Nach In-vitro-Fertilisation (IVF) oder (meist) Intrazytoplasmatischer Spermieninjektion (ICSI) werden entweder Polkörperchen, Blastomere oder Ektodermzellen aus den Oozyten bzw. dem Präimplantationsembryo gewonnen, um sie...

Polar body array CGH for prediction of the status of the corresponding oocyte. Part II: technical aspects

M. Cristina Magli Markus Montag Maria Ko ster Luigi Muzi Joep Geraedts John Collins Veerle Goossens Alan H. Handyside Joyce Harper Sjoerd Repping Andreas Schmutzler Katerina Vesela Luca Gianaroli

What next for preimplantation genetic screening? A polar body approach!

Joep Geraedts John Collins Luca Gianaroli Veerle Goossens Alan Handyside Joyce Harper Markus Montag Sjoerd Repping Andreas Schmutzler Screening of human preimplantation embryos for numerical

Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results

BACKGROUND Several randomized controlled trials have not shown a benefit from preimplantation genetic screening (PGS) biopsy of cleavage-stage embryos and assessment of up to 10 chromosomes for aneuploidy. Therefore, a proof-of-principle study was planned to determine the reliability of alternative form of PGS, i.e. PGS by polar body (PB) biopsy, with whole genome amplification...

What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium steering committee†

Since 2004, there have been 11 randomized controlled trials (RCTs) mainly for advanced maternal age (AMA), which have shown no benefit of performing preimplantation genetic screening (PGS). Ten of the RCTs have been performed at the cleavage stage and one at the blastocyst stage. It is probable that the high levels of chromosomal mosaicism at cleavage stages, which may result in...

Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis

BACKGROUND Preimplantation genetic diagnosis or screening (PGD, PGS) involves embryo biopsy on Day 3. Opting for one- or two-cell biopsy is a balance between the lowest risk for misdiagnosis on the one hand and the highest chance for a pregnancy on the other hand. METHODS A prospective controlled trial was designed and 592 ICSI cycles were randomly assigned to the one-cell (group...