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Search: authors:"Vijayasree V. Giridharan"

7 papers found.
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A cerebrospinal fluid biosignature for the diagnosis of Alzheimer’s disease

EDITORIALA cerebrospinal fluid biosignature for the diagnosis of Alzheimer’s diseaseTatiana Barichello1  2  http://orcid.org/0000-0001-7776-8454Vijayasree V. Giridharan1  Felipe Dal-Pizzol2  1Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX...

The role of the microbiota-gut-brain axis in neuropsychiatric disorders

The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and the central nervous system. The complexity of the intestinal ecosystem is extraordinary; it comprises more than 100 trillion microbial cells that inhabit the small and large intestine, and this interaction between microbiota and intestinal epithelium can cause physiological...

Neuroinflammation trajectories precede cognitive impairment after experimental meningitis—evidence from an in vivo PET study

AuthorsSearch for Vijayasree V. Giridharan in:PubMed • Google Scholar Search for Allan Collodel in:PubMed • Google Scholar Search for Jaqueline S. Generoso in:PubMed • Google Scholar Search for Giselli Scaini

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

of Hypertension and Vascular Research, Henry Ford Hospital System for editing the manuscript. Author Contributions Conceptualization: Vijayasree V. Giridharan, Kenichi Watanabe. Data curation ... : Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V. Giridharan, Suresh S. Palaniyandi. 13 / 16 Formal analysis: Vengadeshprabhu Karuppagounder, Anamika

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

The aim of this study was to investigate the role of macrophage polarization in aging heart. Macrophage differentiation is pathogenically linked to many inflammatory and immune disorders. It is often preceded by myocardial inflammation, which is characterized by increased cardiac damage and pro-inflammatory cytokine levels. Therefore, we investigated the hypothesis that...

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

Doxorubicin (Dox) is a highly effective antineoplastic drug. However, Dox-induced apoptosis in cardiomyocytes leads to irreversible degenerative cardiomyopathy, which limits Dox clinical application. Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has been shown to protect against oxidative damage in liver, heart and...

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression

Amyloid β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Our previous studies have demonstrated that schisandrin B (Sch B), an antioxidant lignan from Schisandra chinensis, could protect mouse brain against scopolamine- and cisplatin-induced neuronal dysfunction. In the present study, we examined the protective effect of Sch B against...