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In vitro and in vivo toxicity assessment of nanoparticles

Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The...

A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India

Background None of the available mortality predicting models in pediatric burns precisely predicts outcomes in every population. Mortality rates as well as their risk factors vary with regions and among different centers within the regions. The aim of this study was to identify socio-demographic and clinical risk factors for mortality in pediatric burns in an effort to decrease...

Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway

Vinay Kumar Sharma 0 Savita Yadav 0 Sharmistha Dey 0 0 Department of Biophysics, All India Institute of Medical Sciences , Ansari Nagar, New Delhi 110 029 , India The black turtle bean (BTB) is most

Biodegradation of endocrine disruptor dibutyl phthalate (DBP) by a newly isolated Methylobacillus sp. V29b and the DBP degradation pathway

Bacteria of the genus Methylobacillus are methanotrophs, a metabolic feature that is widespread in the phylum Proteobacteria. The study demonstrates the isolation and characterization of a newly isolated Methylobacillus sp. V29b. which grows on methanol, protocatechuate, monobutyl phthalate, dibutyl phthalate, diethyl phthalate, benzyl butyl phthalate, dioctyl phthalate and...

Effects of histatin-1 peptide on human corneal epithelial cells

Purpose Ocular surface and corneal epithelial wounds are common and potentially debilitating problems. Ideal treatments for these injuries would promote epithelial healing without inflammation, infection and scarring. In addition the best treatments would be cost-efficient, effective, non-toxic and easily applied. Histatin-1 peptides have been shown to be safe and effective...

Molecular docking studies of 3-bromopyruvate and its derivatives to metabolic regulatory enzymes: Implication in designing of novel anticancer therapeutic strategies

Altered metabolism is an emerging hallmark of cancer, as malignant cells display a mammoth up-regulation of enzymes responsible for steering their bioenergetic and biosynthetic machinery. Thus, the recent anticancer therapeutic strategies focus on the targeting of metabolic enzymes, which has led to the identification of specific metabolic inhibitors. One of such inhibitors is 3...

Magnetohydrodynamics flow of a nanofluid driven by a stretching/shrinking sheet with suction

The present paper investigates the effect of a mathematical model describing the aforementioned process in which the ambient nanofluid in the presence of suction/injection and magnetic field are taken into consideration. The flow is induced by an infinite elastic sheet which is stretched along its own plane. The stretching/shrinking of the sheet is assumed to be proportional to...

The CRISPR–Cas system for plant genome editing: advances and opportunities

Genome editing is an approach in which a specific target DNA sequence of the genome is altered by adding, removing, or replacing DNA bases. Artificially engineered hybrid enzymes, zinc-finger nucleases (ZFNs), and transcription activator-like effector nucleases (TALENs), and the CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated protein...

Human Lacrimal Gland Gene Expression

Background The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression...

The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)

Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many non-histone proteins, including eukaryotic elongation factor 1 alpha (eEF1A). However, the functional significance of eEF1A methylation remains obscure and it has remained unclear whether eEF1A methylation is dynamic and subject...

Deciphering Transcriptional Programming during Pod and Seed Development Using RNA-Seq in Pigeonpea (Cajanus cajan)

Seed development is an important event in plant life cycle that has interested humankind since ages, especially in crops of economic importance. Pigeonpea is an important grain legume of the semi-arid tropics, used mainly for its protein rich seeds. In order to understand the transcriptional programming during the pod and seed development, RNA-seq data was generated from embryo...

G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation

Differentiation of skeletal muscle cells, like most other cell types, requires a permanent exit from the cell cycle. The epigenetic programming underlying these distinct cellular states is not fully understood. In this study, we provide evidence that the lysine methyltransferase G9a functions as a central axis to regulate proliferation and differentiation of skeletal muscle cells...

G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation

Differentiation of skeletal muscle cells, like most other cell types, requires a permanent exit from the cell cycle. The epigenetic programming underlying these distinct cellular states is not fully understood. In this study, we provide evidence that the lysine methyltransferase G9a functions as a central axis to regulate proliferation and differentiation of skeletal muscle cells...

Mechanochemically synthesized kalsilite based bioactive glass-ceramic composite for dental vaneering

, Singh VK ( 2014b ) Role of CaF2 on mechanochemically synthesized leucite as dental veneering glass ceramics . Adv Appl Ceram 114 : 107 - 113 Kumar Pattem Hemanth , Singh Vinay Kumar, Srivastava Abhinav ... of Chemical Engineering and Technology, Indian Institute of Technology (BHU) , Varanasi , India 1 Department of Ceramic Engineering, Indian Institute of Technology (BHU) , Varanasi , India 2 & Vinay

Durability of fluoropolymer and antibacterial finishes on woven surgical gown fabrics

Commercially available polyester, polyester-cotton and cotton plain woven fabrics of 150 g/m2 weight and cotton woven fabric samples of 200 g/m2 weight with plain, twill and satin weave were studied for their suitability as surgical gowns. Water repellent and anti bacterial finishes were applied in single bath using pad-dry-cure method with four concentration levels of these...

Seismic Stability Analysis of Reinforced Soil Wall Using Horizontal Slice Method

The seismic stability of a reinforced soil wall has been analyzed using the horizontal slice method considering the pseudo-static seismic forces. The effect of various parameters including wall inclination angle, angle of internal friction of soil, horizontal seismic loading, cohesion of the backfill and surcharge loading has been examined. It is found that the stability of a...

Gallstones: A Worldwide Multifaceted Disease and Its Correlations with Gallbladder Carcinoma

Background Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed...

Crystal Structure of Allophycocyanin from Marine Cyanobacterium Phormidium sp. A09DM

Isolated phycobilisome (PBS) sub-assemblies have been widely subjected to X-ray crystallography analysis to obtain greater insights into the structure-function relationship of this light harvesting complex. Allophycocyanin (APC) is the phycobiliprotein always found in the PBS core complex. Phycocyanobilin (PCB) chromophores, covalently bound to conserved Cys residues of α- and...