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The physiological determinants of low-level urine cadmium: an assessment in a cross-sectional study among schoolchildren

Haufroid 0 Alfred Bernard 0 0 Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain , Avenue Emmanuel Mounier

Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism

Vandercam 1 Vincent Haufroid Giuseppe Vittorio De Socio, Azienda Ospedaliera Universitaria di Perugia, ITALY 0 Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics, Louvain Drug Research

Preeclampsia and toxic metals: a case-control study in Kinshasa, DR Congo

Haufroid 3 Baudouin Buassa-bu-Tsumbu 1 Fons Verdonck Bernard Spitz Benoit Nemery 4 0 Equal contributors 1 Department of Gynecology and Obstetrics, University of Kinshasa, and General Hospital of Kinshasa

ABCB1 1199G>A Genetic Polymorphism (Rs2229109) Influences the Intracellular Accumulation of Tacrolimus in HEK293 and K562 Recombinant Cell Lines

Objective ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux protein implicated in the absorption and the distribution of various compounds, including tacrolimus and cyclosporine A. In vivo studies suggest an association between the ABCB1 1199G>A single nucleotide polymorphism (SNP) and tacrolimus intracellular accumulation. The aim...

Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats

Background Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale dimensions and high aspect ratio, they should be examined for their potential to cause respiratory toxicity. Here, we evaluated the respiratory biopersistence and lung toxicity of 2 samples of nanometer-long Ge-imogolites...

Bone resorption and environmental exposure to cadmium in children: a cross - sectional study

Background Exposure to cadmium has been associated with osteoporosis and fracture risk in women and elderly, but studies in children are lacking. In the present study we investigate the association between markers of bone demineralization [urinary calcium (Ca) and deoxypyridinoline (DPD) excretion] and urinary cadmium (Cd) excretion (as an index of lifetime body burden). Methods...

Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers

Abdesselem Taleb Dominique Lison 0 Vincent Haufroid 0 Alfred Bernard 0 0 Unit of Toxicology and Applied Pharmacology, Catholic University of Louvain , Brussels , Belgium Background: Associations of

Variabilité de la mesure de la plombémie pour de faibles concentrations proches du seuil de 100 μg/L : étude multicentrique

Since 1991, the fixed criteria of the Centers for Disease Control (CDC) for blood lead determination are used to define acceptable ranges: +/- 40 μg/L for the specimens with target values < 400 μg/L and +/- 10% for specimens with targets exceeding 400 μg/L. Nowadays, considering the threshold for obligatory notification of lead poisoning is 100 μg/L and the evolution of methods...

Approche analytique de la limite de quantification pour le dosage du plomb sanguin : étude multicentrique

In France, the results of blood lead concentration assays for the diagnosis and epidemiological monitoring of lead poisoning in children are expressed differently depending on the laboratory. It would appear that the significance level of the value issued corresponds either to the limit of detection (LOD) or the limit of quantification (LOQ) and that this value falls within a...

Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA

Pavel Vodicka 3 Rajiv Kumar 0 1 Rudolf Stetina 7 Somali Sanyal 1 Pavel Soucek 6 Vincent Haufroid 5 Maria Dusinska 4 Miroslava Kuricova 4 Maria Zamecnikova 9 Ludovit Musak 8 Jana Buchancova 8 Hannu