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Search: authors:"Virginie M. S. Betin"

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Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor

Aims/hypothesis Podocytes are insulin-responsive cells of the glomerular filtration barrier and are key in preventing albuminuria, a hallmark feature of diabetic nephropathy. While there is evidence that a loss of insulin signalling to podocytes is detrimental, the molecular mechanisms underpinning the development of podocyte insulin resistance in diabetes remain unclear. Thus, we ...

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

Virginie M. S. Betin 0 Jon D. Lane ) 0 0 Cell Biology Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk , Bristol BS8 1TD , UK - Summary