, 2018; Accepted: November 09, 2018 Correspondence: Vladimir Hachinski; Distinguished University Professor; Department of Clinical Neurological Sciences, Western University; 339 Windermere Road
, 2018; Accepted: November 09, 2018 Correspondence: Vladimir Hachinski; Distinguished University Professor; Department of Clinical Neurological Sciences, Western University; 339 Windermere Road
, 2018; Accepted: November 09, 2018 Correspondence: Vladimir Hachinski; Distinguished University Professor; Department of Clinical Neurological Sciences, Western University; 339 Windermere Road
Hachinski 2 0 Shariati Hospital; Tehran University of Medical Sciences; Tehran , Iran 1 Rush Alzheimer's Disease Center; Rush University Medical Center; Chicago, IL , USA 2 Department of Clinical Neurological
Conceptualization: Narlon Cassio Boa Sorte Silva, Dawn P. Gill, Teresa Liu-Ambrose, Vladimir Hachinski, Ryosuke Shigematsu, Robert J. Petrella. Data curation: Narlon Cassio Boa Sorte Silva. Formal analysis: Narlon ... Sorte Silva, Dawn P. Gill, Adrian M. Owen, Teresa Liu Ambrose, Vladimir Hachinski, Ryosuke Shigematsu, Robert J. Petrella. Project administration: Dawn P. Gill. Supervision: Robert J. Petrella
Most of the animal models commonly used for preclinical research into Alzheimer’s disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that does not develop AD-like pathology spontaneously with age, but does develop pathology following...
BackgroundAccurate and timely diagnosis of Alzheimer’s disease (AD) is important for prompt initiation of treatment in patients with AD and to avoid inappropriate treatment of patients with false-positive diagnoses.MethodsUsing a Markov model, we estimated the lifetime costs and quality-adjusted life-years (QALYs) of cerebrospinal fluid biomarker analysis in a cohort of patients...
Accurate and timely diagnosis of Alzheimer’s disease (AD) is important for prompt initiation of treatment in patients with AD and to avoid inappropriate treatment of patients with false-positive diagnoses. Using a Markov model, we estimated the lifetime costs and quality-adjusted life-years (QALYs) of cerebrospinal fluid biomarker analysis in a cohort of patients referred to a...
Vascular dementia (VaD) is the second most common form of dementia. However, there were mixed evidences about the association between blood pressure (BP) and risk of VaD in midlife and late life and limited evidence on the association between pulse pressure and VaD. This is a population-based observational study. 265,897 individuals with at least one BP measurement between the...
Background Dementia is a major public health problem that poses an increasing burden on the health and wealth of societies worldwide. Because the efficacy of current treatments is limited, increasing efforts are required to prevent the diseases that cause dementia. Discussion We consider the evidence that lifelong prevention strategies may be an effective way to tackle the...
Dementia is a major public health problem that poses an increasing burden on the health and wealth of societies worldwide. Because the efficacy of current treatments is limited, increasing efforts are required to prevent the diseases that cause dementia. We consider the evidence that lifelong prevention strategies may be an effective way to tackle the national burden of dementia...
Until recently, the study of cognitive impairment as a manifestation of cerebrovascular disease (CVD) has been hampered by the lack of common standards for assessment. The term vascular cognitive impairment (VCI) encompasses all levels of cognitive decline associated with CVD from mild deficits in one or more cognitive domains to crude dementia syndrome. VCI incorporates the...
Background Dementia is associated with cognitive and functional deficits, and poses a significant personal, societal, and economic burden. Directing interventions towards older adults with self-reported cognitive complaints may provide the greatest impact on dementia incidence and prevalence. Risk factors for cognitive and functional deficits are multifactorial in nature; many...
Dementia is associated with cognitive and functional deficits, and poses a significant personal, societal, and economic burden. Directing interventions towards older adults with self-reported cognitive complaints may provide the greatest impact on dementia incidence and prevalence. Risk factors for cognitive and functional deficits are multifactorial in nature; many are...
Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer’s disease. However, we do not know which type 2 diabetes patients will dement or which biomarkers predict cognitive decline. Left ventricular hypertrophy (LVH) is potentially such a marker. LVH is highly prevalent in type 2 diabetes and is a strong...
The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear. Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia, and emphasize consequences rather than causes, the true bases for treatment and prevention. We should throw out current...
Background Vitamin D is involved in brain physiology and lower-extremity function. We investigated spectroscopy in a cohort of older adults to explore the hypothesis that lower vitamin D status was associated with impaired neuronal function in caudal primary motor cortex (cPMC) measured by proton magnetic resonance spectroscopic imaging. Methods Twenty Caucasian community...
Peter Srs 0 Faisal Al-Otaibi Savio WH Wong J Kevin Shoemaker Seyed M Mirsattari Vladimir Hachinski Ruth E Martin 0 0 School of Communication Sciences and Disorders, University of Western Ontario
Various functional resonance imaging, magnetoencephalographic and lesion studies suggest the involvement of the insular cortex in the control of swallowing. However, the exact location of insular activation during swallowing and its functional significance remain unclear. Invasive electroencephalographic monitoring was performed in a 24-year-old man with medically intractable...
