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Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential

, 1515 Holcombe Boulevard, Houston, 77030, TX, USAHélène Pelicano, Wan Zhang, Jinyun Liu, Naima Hammoudi, Jiale Dai & Peng HuangThe First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi ... . Anderson Cancer Center, Houston, 77030, TX, USALajos PusztaiYale School of Medicine, New Haven, CT, USALajos Pusztai AuthorsSearch for Hélène Pelicano in:PubMed • Google Scholar Search for Wan Zhang

Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential

Introduction Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agents, therefore, further understanding of the biological properties of these cancer cells and development of effective therapeutic approaches are urgently needed...