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18 papers found.
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Divide-and-conquer quantum mechanical material simulations with exascale supercomputers

Recent developments in large-scale materials science simulations, especially under the divide-and-conquer method, are reviewed. The pros and cons of the divide-and-conquer method are discussed. It is argued that the divide-and-conquer method, such as the linear-scaling 3D fragment method, is an ideal approach to take advantage of the heterogeneous architectures of modern-day...

Diagnostic Accuracy of NT-ProBNP for Heart Failure with Sepsis in Patients Younger than 18 Years

This clinical study investigated plasma NT-proBNP levels as a potential predictor of heart failure in pediatric patients with sepsis. Plasma NT-ProBNP levels of 211 pediatric patients with sepsis and 126 healthy children were measured. Patients were stratified as with heart failure (HF) or without heart failure (non-HF). Patients were graded as having sepsis, severe sepsis, or...

Hidden burrow plugs and their function in the tiger beetle, Cosmodela batesi (Coleoptera, Cicindelidae)

Shou-Wang Lin 0 Toshinori Okuyama 0 0 S.-W. Lin T. Okuyama (&) Department of Entomology, National Taiwan University , No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan Tiger beetle larvae excavate

Exact Asymptotic Stability Analysis and Region-of-Attraction Estimation for Nonlinear Systems

We address the problem of asymptotic stability and region-of-attraction analysis of nonlinear dynamical systems. A hybrid symbolic-numeric method is presented to compute exact Lyapunov functions and exact estimates of regions of attraction of nonlinear systems efficiently. A numerical Lyapunov function and an estimate of region of attraction can be obtained by solving an...

Automatic Lung Tumor Segmentation on PET/CT Images Using Fuzzy Markov Random Field Model

The combination of positron emission tomography (PET) and CT images provides complementary functional and anatomical information of human tissues and it has been used for better tumor volume definition of lung cancer. This paper proposed a robust method for automatic lung tumor segmentation on PET/CT images. The new method is based on fuzzy Markov random field (MRF) model. The...

Automatic Lung Tumor Segmentation on PET/CT Images Using Fuzzy Markov Random Field Model

The combination of positron emission tomography (PET) and CT images provides complementary functional and anatomical information of human tissues and it has been used for better tumor volume definition of lung cancer. This paper proposed a robust method for automatic lung tumor segmentation on PET/CT images. The new method is based on fuzzy Markov random field (MRF) model. The...

Kinetic Characterization of an Intestinal Trefoil Factor Receptor

Objective To determine whether intestinal epithelial cells have a receptor for intestinal trefoil factor and characterize receptor-ligand binding kinetics. Methods Radioligand binding assays were performed to characterize the binding kinetics between [125I]-labeled ITF and IEC-6, HT-29, Caco2 and HaCaT cells. The Kd, Bmax and other kinetic variables describing the interaction...

Probing DNA clamps with single-molecule force spectroscopy

Detailed mechanisms of DNA clamps in prokaryotic and eukaryotic systems were investigated by probing their mechanics with single-molecule force spectroscopy. Specifically, the mechanical forces required for the Escherichia coli and Saccharomyces cerevisiae clamp opening were measured at the single-molecule level by optical tweezers. Steered molecular dynamics simulations further...

Polygenic Molecular Architecture Underlying Non-Sexual Cell Aggregation in Budding Yeast

Cell aggregation in unicellular organisms, induced by either cell non-sexual adhesion to yield flocs and biofilm, or pheromone-driving sexual conjugation is of great significance in cellular stress response, medicine, and brewing industries. Most current literatures have focused on one form of cell aggregation termed flocculation and its major molecular determinants, the...

Repression of miR-143 Mediates Cr (VI)–Induced Tumor Angiogenesis via IGF-IR/IRS1/ERK/IL-8 Pathway

Hexavalent chromium [Cr (VI)] is a well-known human carcinogen associated with the increased risk of lung cancer. However, the mechanism underlying the Cr (VI)–induced carcinogenesis remains unclear due to the lack of suitable experimental models. In this study, we developed an in vitro model by transforming nontumorigenic human lung epithelial BEAS-2B cells through long-term...

Spermine Attenuates the Action of the DNA Intercalator, Actinomycin D, on DNA Binding and the Inhibition of Transcription and DNA Replication

The anticancer activity of DNA intercalators is related to their ability to intercalate into the DNA duplex with high affinity, thereby interfering with DNA replication and transcription. Polyamines (spermine in particular) are almost exclusively bound to nucleic acids and are involved in many cellular processes that require nucleic acids. Until now, the effects of polyamines on...

An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides

1 Funding: This work was supported by the Howard Hughes Medical Institute. Jack Szostak is an Investigator, and Matthew Hartman, Kris Josephson, and Chi-Wang Lin are/were HHMI Research Associates 2

Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma

This study aimed to establish an effective prognostic nomogram with or without plasma Epstein-Barr virus DNA (EBV DNA) for nondisseminated nasopharyngeal carcinoma (NPC).

Voltage-dependent anion channel (VDAC) is involved in apoptosis of cell lines carrying the mitochondrial DNA mutation

out the molecular genetic studies, participated in the sequence analysis and drafted the manuscript. Xu Hua and Wang Lin carried out the immunoassays. Chen Rui, Liu Mohan and Wen Yi participated in the

Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials

Botanical, mycological, zoological, and prokaryotic species names follow the Linnaean format, consisting of an italicized Latinized binomen with a capitalized genus name and a lower case species epithet (e.g., Homo sapiens). Virus species names, however, do not follow a uniform format, and, even when binomial, are not Linnaean in style. In this thought exercise, we attempted to...