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Oxidative toxicity in diabetes and Alzheimer’s disease: mechanisms behind ROS/ RNS generation

edited the manuscript. All authors read and approved the final manuscript. Authors information Waqar Ahmad is working as Research Officer while Khadija Shabbiri is post-doctoral Research fellow at School

Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L

BackgroundThe emergence of multidrug resistant (MDR) pathogens is of great concern to the global health community. Our ability to effectively treat diseases is based on the discovery of potent drugs for the treatment of these challenging diseases. Traditional medicines are one of the major sources for the discovery of safe, effective and economical drug candidates. In order to...

GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Artemisia indica, also known as “Mugwort,” has been widely used in traditional medicines. However, few studies have investigated the effects of nonvolatile components of Artemisia indica on central nervous system’s function. Fractionation of Artemisia indica led to the isolation of carnosol, ursolic acid, and oleanolic acid which were evaluated for their effects on GABA-A...

Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes

authors have no conflict of interests regarding the publication of this paper. Authors’ Contribution Zainab Jahangir and Waqar Ahmad contributed equally to this work. References D. J. Selkoe

Separation of Organic and Inorganic Compounds for Specific Applications

criticisms, and timely response that made this special issue possible. Hasan Uslu Dragomir Yankov Kailas L. Wasewar Saeid Azizian Najeeb Ullah Waqar Ahmad

Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study

Background Cholinesterase inhibition is a vital target for the development of novel and mechanism based inhibitors, owing to their role in the breakdown of acetylcholine (ACh) neurotransmitter to treat various neurological disorders including Alzheimer’s disease (AD). Similarly, free radicals are implicated in the progression of various diseases like neurodegenerative disorders...

Valuing increased zinc (Zn) fertiliser-use in Pakistan

, Waqar Ahmad, Munir H. Zia , Diriba B 3 School of Biosciences, University of Nottingham , Sutton Bonington Campus, Loughborough LE12 5RD , UK 4 A. J. Stein Agricultural Economist , Brussels , Belgium 5 M ... (Fig. 2). Baseline data for on-farm Zn fertiliser-use were obtained for Punjab and Sindh from a survey of >2500 farmers taken in early 2015 (Waqar Ahmad, personal communication, Food and Agriculture

Enhanced Electrocatalytic Activity by RGO/MWCNTs/NiO Counter Electrode for Dye-sensitized Solar Cells

We applied the reduced graphene oxide/multi-walled carbon nanotubes/nickel oxide (RGO/MWCNTs/NiO) nanocomposite as the counter electrode (CE) in dye-sensitized solar cells (DSSCs) on fluorine-doped tin oxide substrates by blade doctor method. Power conversion efficiency (PCE) of 8.13 % was achieved for this DSSCs device, which is higher than that of DSSCs devices using NiO, RGO...

MHD Boundary Layer Slip Flow and Heat Transfer of Ferrofluid along a Stretching Cylinder with Prescribed Heat Flux

This study investigates the magnetohydrodynamic (MHD) flow of ferrofluid along a stretching cylinder. The velocity slip and prescribed surface heat flux boundary conditions are employed on the cylinder surface. Water as conventional base fluid containing nanoparticles of magnetite (Fe3O4) is used. Comparison between magnetic (Fe3O4) and non-magnetic (Al2O3) nanoparticles is also...

Gene expression profiling of HCV genotype 3a initial liver fibrosis and cirrhosis patients using microarray

Background Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in Asian population, especially Pakistan; the detail mechanism of infection still needs to be explored. In this study, we investigated and compared the gene...

Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis

manuscript. Authors’ information Shah Jahan (PhD molecular Biology) and Saba Khaliq (PhD molecular Biology) are both PhD scholars, Bushra Ijaz (M Phil Molecular Biology) and Waqar Ahmad (M Phil Chemistry) are

Revised cutoff values of ALT and HBV DNA level can better differentiate HBeAg (-) chronic inactive HBV patients from active carriers

. All work was performed under supervision of SH. We all authors read and approved the final manuscript. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry) and

Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line

Molecular Biology), Saba Khaliq (PhD Molecular Biology), Usman Ali Ashfaq (PhD Molecular Biology), Muhammad Hassan Siddiqui (M. Phil Molecular Biology) and Bushra Ijaz and Waqar Ahmad are research officer at

HCV entry receptors as potential targets for siRNA-based inhibition of HCV

Siddique 0 Waqar Ahmad 0 Sajida Hassan 0 0 Applied and Functional Genomics Lab, Centre of Excellence in Molecular Biology, University of the Punjab , Pakistan Background: Hepatitis C virus (HCV) is a major

Development of persistent HCV genotype 3a infection cell culture model in huh-7 cell

Background Hepatitis C virus (HCV) is one of the major health concerns globally, with genotype 3a as the most prevalent in Pakistan. Lack of efficient HCV genotype 3a small animal models as well as genomic replicons has hampered the complete understanding of its life cycle, pathogenesis and therapeutic options. In this study we aimed to develop a persistent HCV genotype 3a...

Huh-7 cell line as an alternative cultural model for the production of human like erythropoietin (EPO)

Background and Aims Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. Availability of recombinant EPO has eliminated the need for blood transfusion and now it is extensively used for the...

The applicability of measures of socioeconomic position to different ethnic groups within the UK

Background In this paper we seek to tease out differences in socioeconomic position between ethnic groups. There are 3 main reasons why conventional socioeconomic indicators and asset based measures may not be equally applicable to all ethnic groups: 1) Differences in response rate to conventional socioeconomic indicators 2) Cultural and social differences in economic priorities...

Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV

Molecular Biolohgy) and Usman Ali Ashfaq (PhD Molecular Biology) are research scholars at CEMB. Bushra Ijaz (M.Phil Molecular Biology) and Waqar Ahmad (M.Phil Chemistry) are research officers at CEMB whereas

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

Background Several factors have been proposed to assess the clinical outcome of HCV infection. The correlation of HCV genotypes to possible serum markers in clinical prediction is still controversial. The main objective of this study was to determine the existence of any correlation between HCV genotypes to viral load and different clinical serum markers. Methods We performed a...