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63 papers found.
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Potential involvement of the 18 kDa translocator protein and reactive oxygen species in apoptosis of THP-1 macrophages induced by sonodynamic therapy

Tian. Tian. Investigation: Xin Sun, Shuyuan Guo, Wei Wang, Zhengyu Cao, Juhua Dan, Jiali Cheng, Wei Methodology: Xin Sun, Shuyuan Guo, Wei Wang, Juhua Dan, Jiali Cheng, Wei Cao, Fang Resources: Wenwu

Self-tuning virtual synchronous generator control for improving frequency stability in autonomous photovoltaic-diesel microgrids

This paper investigates the use of a virtual synchronous generator (VSG) to improve frequency stability in an autonomous photovoltaic-diesel microgrid with energy storage. VSG control is designed to emulate inertial response and damping power via power injection from/to the energy storage system. The effect of a VSG with constant parameters (CP-VSG) on the system frequency is...

ZNF259 inhibits non-small cell lung cancer cells proliferation and invasion by FAK-AKT signaling

ZNF259 inhibits non-small cell lung cancer cells proliferation and invasion by FAK-AKT signaling Yuemei Shan,1,2 Wei Cao,1 Tao Wang,1 Guiyang Jiang,3 Yong Zhang,4 Xianghong Yang1 1Department of

Retrospective analysis of relationships among the dose regimen, trough concentration, efficacy, and safety of teicoplanin in Chinese patients with moderate–severe Gram-positive infections

,1,* Yanqiu Gao,2 Wei Cao,1 Jia Liu,1 Hongya Guan,1 Hua Zhang,2 Yun Shi,3 Wenying Lv,4 Long Cheng5,* 1Translational Medicine Center, 2Department of Respiratory Medicine, Affiliated Zhengzhou Central

Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes

Bufalin was reported to show strong pharmacological effects including cardiotonic, antiviral, immune-regulation, and especially antitumor effects. The objective of this study was to determine the characterization, antitumor efficacy, and pharmacokinetics of bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical...

A multi-pattern hash-binary hybrid algorithm for URL matching in the HTTP protocol

In this paper, based on our previous multi-pattern uniform resource locator (URL) binary-matching algorithm called HEM, we propose an improved multi-pattern matching algorithm called MH that is based on hash tables and binary tables. The MH algorithm can be applied to the fields of network security, data analysis, load balancing, cloud robotic communications, and so on—all of...

Development of a prediction system for tail-anchored proteins

Background “Tail-anchored (TA) proteins” is a collective term for transmembrane proteins with a C-terminal transmembrane domain (TMD) and without an N-terminal signal sequence. TA proteins account for approximately 3–5 % of all transmembrane proteins that mediate membrane fusion, regulation of apoptosis, and vesicular transport. The combined use of TMD and signal sequence...

Construction of efficient Streptococcus zooepidemicus strains for hyaluoronic acid production based on identification of key genes involved in sucrose metabolism

Biosynthesis of polysaccharide hyaluoronic acid (HA) by Streptococcus zooepidemicus is a carbon-intensive process. The carbon flux and factor(s) restricting HA yield were not well understood. Here, we investigated the function of genes involved in sucrose metabolism and identified targets limiting HA yield, which were exploited to construct efficient S. zooepidemicus strains for...

Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes

Background Cerebral oedema is closely related to the permeability of blood–brain barrier, vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) all of which are important blood–brain barrier (BBB) permeability regulatory factors. Zonula occludens 1 (ZO-1) and claudin-5 are also the key components of BBB. Hypertonic...

Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China

Exact prediction of Hemorrhagic fever with renal syndrome (HFRS) epidemics must improve to establish effective preventive measures in China. A Seasonal Autoregressive Integrated Moving Average (SARIMA) model was applied to establish a highly predictive model of HFRS. Meteorological factors were considered external variables through a cross correlation analysis. Then, these...

Treatment of osteoarthritis with mesenchymal stem cells

Osteoarthritis (OA) is one of the most prevalent joint diseases with prominent symptoms affecting the daily life of millions of middle aged and elderly people. Despite this, there are no successful medical interventions that can prevent the progressive destruction of OA joints. The onset of pathological changes in OA is associated with deviant activity of mesenchymal stem cells...

Polyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors

Background Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs (oseltamivir and zanamivir) don’t seem to be optimistic due to the spontaneously arising and spreading of oseltamivir resistance among influenza virus. Pogostemon cablin (Blanco) Benth. (P. cablin) is an important...

In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model

Background Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. However, understanding the mode of action of the cell therapy has been limited by cell tracking capability and correlation between the pharmacokinetics of the injected cells and the intended...

qiRNApredictor: A Novel Computational Program for the Prediction of qiRNAs in Neurospora crassa

Recently, a new type of small interfering RNAs (qiRNAs) of typically 20~21 nucleotides was found in Neurospora crassa and rice and has been shown to regulate gene silencing in the DNA damage response. Identification of qiRNAs is fundamental for dissecting regulatory functions and molecular mechanisms. In contrast to other expensive and time-consuming experimental methods, the...

Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis

Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis Zhen Chen,1,* Yingjie Shao,2,* Kun Wang,1 Wei Cao,1 Yulong Xiong,1 Rongzu Wu,1 Shicheng ... to scientific and medical research O r i g i n a l r e s e a r c h Zhen chen 1,* Yingjie shao 2,* Kun Wang1 Wei cao 1 Yulong Xiong1 rongzu Wu 1 shicheng luo 1 Introduction Renal cell carcinoma

Predicting postoperative complications of head and neck squamous cell carcinoma in elderly patients using random forest algorithm model

Chen 0 Wei Cao 0 XianChao Gao HuiShan Ong Tong Ji 0 Equal contributors Department of Oral Maxillofacial-Head Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University

Analysis of Pigeon (Columba) Ovary Transcriptomes to Identify Genes Involved in Blue Light Regulation

Monochromatic light is widely applied to promote poultry reproductive performance, yet little is currently known regarding the mechanism by which light wavelengths affect pigeon reproduction. Recently, high-throughput sequencing technologies have been used to provide genomic information for solving this problem. In this study, we employed Illumina Hiseq 2000 to identify...

Morphological and Hemodynamic Discriminators for Rupture Status in Posterior Communicating Artery Aneurysms

Background and Purpose The conflicting findings of previous morphological and hemodynamic studies on intracranial aneurysm rupture may be caused by the relatively small sample sizes and the variation in location of the patient-specific aneurysm models. We aimed to determine the discriminators for aneurysm rupture status by focusing on only posterior communicating artery (PCoA...

The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial

Background Knee osteoarthritis (KOA) is a major public health issue causing chronic disability as well as a burden on healthcare resources. In China, a herbal drug tablet has been used as an effective and conventional therapy to alleviate clinical symptoms caused by KOA. However, evidence gathered from systematic reviews or randomized controlled trials that validated herbal drugs...

Direct Sum Matrix Game with Prisoner's Dilemma and Snowdrift Game

A direct sum form is proposed for constructing a composite game from two games, prisoner's dilemma and snowdrift game. This kind of direct sum form game is called a multiple roles game. The replicator dynamics of the multiple roles game with will-mixed populations is explored. The dynamical behaviors on square lattice are investigated by numerical simulation. It is found that the...