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An ultrasonic nanobubble-mediated PNP/fludarabine suicide gene system: A new approach for the treatment of hepatocellular carcinoma

: Mingna Chen, Youming Zhang, Wei Chen. Methodology: Youming Zhang. Resources: Lihua Zhang, Lv Chen. Software: Mingna Chen, Wei Chen. Supervision: Wei Chen, Lihua Zhang, Lv Chen. Validation: Lihua Zhang

Longitudinal variation in lateral trapping of fine sediment in tidal estuaries: observations and a 3D exploratory model

This study investigates the longitudinal variation of lateral entrapment of suspended sediment, as is observed in some tidal estuaries. In particular, field data from the Yangtze Estuary are analysed, which reveal that in one cross-section, two maxima of suspended sediment concentration (SSC) occur close to the south and north sides, while in a cross-section 2 km down-estuary...

Current challenges and visions in music recommender systems research

Music recommender systems (MRSs) have experienced a boom in recent years, thanks to the emergence and success of online streaming services, which nowadays make available almost all music in the world at the user’s fingertip. While today’s MRSs considerably help users to find interesting music in these huge catalogs, MRS research is still facing substantial challenges. In...

Stability of braneworlds with non-minimally coupled multi-scalar fields

Linear stability of braneworld models constructed with multi-scalar fields is very different from that of single-scalar field models. It is well known that both the tensor and the scalar perturbations of the latter are stable at linear level. However, in general there is no effective method to deal with the stability problem of the scalar perturbations for braneworld models...

PbCrO4 yellow-pigment nanorods: An efficient and stable visible-light-active photocatalyst for O2 evolution and photodegradation

Here, PbCrO4 nanorods, a commonly used and low-cost yellow pigment, was synthesized via a simple precipitation reaction and can serve as a highly efficient oxygen production and photodegradation photocatalyst. The obtained PbCrO4 nanorods exhibit excellent stability and photocatalytic performance for O2 evolution from water. The production rate is approximately 314.0 μmol h−1 g−1...

Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1

Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic...

The corneal epitheliotrophic abilities of lyophilized powder form human platelet lysates

their technological support. Author Contributions Conceptualization: Wei-Li Chen. Data curation: Lily Wei Chen, Chien-Jung Huang. Formal analysis: Lily Wei Chen, Chien-Jung Huang, Wei-Li Chen ... . Funding acquisition: Wei-Li Chen. Methodology: Chia-Ju Lu, Yi-Chen Sun. Project administration: Chia-Ju Lu, Szu-Yuan Lin. Resources: Yi-Chen Sun, Szu-Yuan Lin. Writing ± original draft: Lily Wei Chen

Population-based study of chlamydial and gonococcal infections among women in Shenzhen, China: Implications for programme planning

. Funding acquisition: Min Zhang. Investigation: Zhen-Zhou Luo, Wu Li, Qiu-Hong Wu, Li Zhang, Li-Shan Tian, Lan-Lan Liu, Yi Ding, Jun Yuan, Zhong-Wei Chen. Project administration: Wu Li, Qiu-Hong Wu, Li

Effect of low and high HDL-C levels on the prognosis of lupus nephritis patients: a prospective cohort study

Few data has been available on the effect of serum HDL-C levels on the prognosis of lupus nephritis (LN) patients. The present study therefore aimed to explore the effect of serum HDL-C levels on LN patients. We included 775 patients with follow-up information registered in an LN database between 1 January 2006 and 31 December 2011. The patients were divided into groups with low...

A comprehensive nutritional survey of hospitalized patients: Results from nutritionDay 2016 in China

: Haifeng Sun, Li Zhang, Xinying Wang. Investigation: Haifeng Sun, Li Zhang, Pianhong Zhang, Jianchun Yu, Weiming Kang, Shuli Guo, Wei Chen, Xuqi Li, Shufeng Wang, Lianzhen Chen, Jianxiong Wu, Zibin Tian

Comparison of the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in emergency departments of general hospitals in China

Major depressive disorder (MDD) is a known major risk factor for suicide due to the high suicide mortality. However, studies comparing the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in China are very limited. This study examined and compared the sociodemographic and psychological characteristics of suicide...

Comparison of the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in emergency departments of general hospitals in China

Major depressive disorder (MDD) is a known major risk factor for suicide due to the high suicide mortality. However, studies comparing the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in China are very limited. This study examined and compared the sociodemographic and psychological characteristics of suicide...

Modeling Expert Behavior in Support of an Adaptive Psychomotor Training Environment: a Marksmanship Use Case

The U.S. Army is interested in extending the application of intelligent tutoring systems (ITS) beyond cognitive problem spaces and into psychomotor skill domains. In this paper, we present a methodology and validation procedure for creating expert model representations in the domain of rifle marksmanship. GIFT (Generalized Intelligent Framework for Tutoring) was used as the...

A coupled model on fluid flow, heat transfer and solidification in continuous casting mold

Fluid flow, heat transfer and solidification of steel in the mold are so complex but crucial, determining the surface quality of the continuous casting slab. In the current study, a 2D numerical model was established by Fluent software to simulate the fluid flow, heat transfer and solidification of the steel in the mold. The VOF model and k-ε model were applied to simulate the...

How disentangled sense of agency and sense of ownership can interact with different emotional events on stress feelings

pick up affective processes in the coin task. Further studies would be better to adopt both questionnaire and objective measurements. Acknowledgements Wei Chen and Jing Zhang contribute equally to this

HPV11 E6 mutation by overexpression of APOBEC3A and effects of interferon-ω on APOBEC3s and HPV11 E6 expression in HPV11.HaCaT cells

Condyloma acuminatum, infected by low-risk human papillomaviruses (e.g., HPV6 and HPV11), is one of the most widespread sexually transmitted diseases. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 proteins (APOBEC3s, A3s) are cellular cytidine deaminases acting as antiviral factors through hypermutation of viral genome. However, it remains unknown whether A3s...

Age-, gender- and Arbeitsgemeinschaft für Osteosynthesefragen type-specific clinical characters of adult tibial plateau fractures in eighty three hospitals in China

; Age distribution; AO classification; Epidemiology - Peizhi Yuwen, Hongzhi Lv, Wei Chen and Wang Yefang contributed equally to this work. Department of Orthopaedic Surgery, The Third Hospital of Hebei ... , for their assistance and cooperation in this study. This study was supported by the National Natural Science Foundation of China (Grant No. 81401789). Authors’ contributions Yingze Zhang and Wei Chen

Biosensor-aided high-throughput screening of hyper-producing cells for malonyl-CoA-derived products

Malonyl-coenzyme A (CoA) is an important biosynthetic precursor in vivo. Although Escherichia coli is a useful organism for biosynthetic applications, its malonyl-CoA level is too low. To identify strains with the best potential for enhanced malonyl-CoA production, we developed a whole-cell biosensor for rapidly reporting intracellular malonyl-CoA concentrations. The biosensor...