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Longitudinal validity and reliability of the Myeloma Patient Outcome Scale (MyPOS) was established using traditional, generalizability and Rasch psychometric methods

Purpose The Myeloma Patient Outcome Scale (MyPOS) was developed to measure quality of life in routine clinical care. The aim of this study was to determine its longitudinal validity, reliability, responsiveness to change and its acceptability. Methods This 14-centre study recruited patients with multiple myeloma. At baseline and then every two months for 5 assessments, patients ...

Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3

does not have a funding to this research. Author Contributions Conceptualization: Wei Gao, Lihui Zhang, Bin Wang. Data curation: Qi Feng, Jianyao Wang, Xiaoshuo Ye. Formal analysis: Zhihan Li

Molecular cloning, characterization and expression analysis of Frizzled 6 in the small intestine of pigs (Sus scrofa)

Frizzled 6 (FZD6) encodes an integral membrane protein that functions in multiple signal transduction pathways, for example, as a receptor in Wnt/planar cell polarity (PCP) signaling pathway for polarized cell migration and organ morphogenesis. Mutations in FZD6 have been identified in a variety of tumors. In this study, the full-length cDNA of Sus scrofa FZD6 (Sfz6) was cloned and ...

Elastic–plastic model identification for rock surrounding an underground excavation based on immunized genetic algorithm

To compute the stability of underground engineering, a constitutive model of surrounding rock must be identified. Many constitutive models for rock mass have been proposed. In this model identification study, a generalized constitutive law for an elastic–plastic constitutive model is applied. Using the generalized constitutive law, the problem of model identification is transformed ...

Which patients with advanced respiratory disease die in hospital? A 14-year population-based study of trends and associated factors

the GUIDE_Care project: Irene J Higginson (PI), Wei Gao, Julia Verne, Myer Glickman, and Barbara Gomes. Members of the Project Advisory Group (PAG): Tony Bonser, Shaheen Khan, Jonathan Koffman, Katie

Developments in breeding of Agaricus bisporus var. bisporus: progress made and technical and legal hurdles to take

True breeding of button mushrooms has hardly been done in the last decades, despite this species being one of the most cultivated mushrooms worldwide. Research done in the last 20 years has identified and characterised new germplasm and improved our understanding of the genetic base for some traits. A substantial collection of wild-collected strains is now available and partly ...

Quorum sensing of microalgae associated marine Ponticoccus sp. PD-2 and its algicidal function regulation

Quorum sensing (QS) systems play important roles in regulating many physiological functions of microorganisms, such as biofilm formation, bioluminescence, and antibiotic production. One marine algicidal bacterium, Ponticoccus sp. PD-2, was isolated from the microalga Prorocentrum donghaiense, and its N-acyl-homoserine lactone (AHL)-mediated QS system was verified. In this study, we ...

The role of adenosinergic pathway in human autoimmune diseases

Autoimmune diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state of appropriate immune response to nonself-antigen and unresponsiveness to self-antigens. In normal situation, immune homeostasis is regulated by immunosuppressive signal and ...

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

Background CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and metastasis, but this non-enzymatic function of CD73 in cervical cancer ...

Place of death in children and young people with cancer and implications for end of life care: a population-based study in England, 1993–2014

, number of CYP deaths and number of CYP cancer deaths at SCN region level. -: not estimable Acknowledgements The investigators of the GUIDE_Care Children and Young People project: Wei Gao(PI), Irene J

Distance-based topological polynomials and indices of friendship graphs

Drugs and chemical compounds are often modeled as graphs in which the each vertex of the graph expresses an atom of molecule and covalent bounds between atoms are represented by the edges between their corresponding vertices. The topological indicators defined over this molecular graph have been shown to be strongly correlated to various chemical properties of the compounds. In ...

Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration

Background High density lipoprotein (HDL) has been proved to be a protective factor for coronary heart disease. Notably, HDL in atherosclerotic plaques can be nitrated (NO 2 -oxHDL) and chlorinated (Cl-oxHDL) by myeloperoxidase (MPO), likely compromising its cardiovascular protective effects. Method Here we determined the effects of NO 2 -oxHDL and Cl-oxHDL on SMC migration using ...

A Nomogram to Predict Adequate Lymph Node Recovery before Resection of Colorectal Cancer

Increased lymph node count (LNC) has been associated with prolonged survival in colorectal cancer (CRC), but the underlying mechanisms are still poorly understood. The study aims to identify new predictors and develop a preoperative nomogram for predicting the probability of adequate LNC (≥ 12). 501 eligible patients were retrospectively selected to identify clinical-pathological ...

Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells

Heparan sulfate proteoglycans (HSPGs) participate in many processes related to tumor development, including tumorigenesis and metastasis. HSPGs contain one or more heparan sulfate (HS) chains that are covalently linked to a core protein. Glypican-3 (GPC3) is a cell surface-associated HSPG that is highly expressed in hepatocellular carcinoma (HCC). GPC3 is involved in ...

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

Background Multiple myeloma, the second most common haematological cancer, remains incurable. Its incidence is rising due to population ageing. Despite the impact of the disease and its treatment, not much is known on who is most in need of supportive and palliative care. This study aimed to (a) assess symptom severity, palliative care concerns and health-related quality of life ...

Multi-trait QTL analysis for agronomic and quality characters of Agaricus bisporus (button mushrooms)

The demand for button mushrooms of high quality is increasing. Superior button mushroom varieties require the combination of multiple traits to maximize productivity and quality. Very often these traits are correlated and should, therefore, be evaluated together rather than as single traits. In order to unravel the genetic architecture of multiple traits of Agaricus bisporus and ...

Plasma Catestatin: A Useful Biomarker for Coronary Collateral Development with Chronic Myocardial Ischemia

Backgrounds Catestatin is an endogenous multifunctional neuroendocrinepeptide. Recently, catestatin was discovered as a novel angiogenic cytokine. The study was to investigate the associations between endogenous catestatin and coronary collateral development among the patients with chronic myocardial ischemia. Methods Thirty-eight patients with coronary artery chronic total ...

Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma

Background Brain-expressed X-linked (BEX) 4 is a member of BEX family. The functional role of BEX4 in oral squamous cell carcinoma (OSCC) remains unknown. Methods Expression level of BEX family members (BEX1-5) in OSCC tissues and the paired normal epithelial were examined. Functions of epigenetic changes (DNA methylation and histone modifications) on BEX4 suppression in OSCC were ...

Psychometric Properties of a Generic, Patient-Centred Palliative Care Outcome Measure of Symptom Burden for People with Progressive Long Term Neurological Conditions

Background There is no standard palliative care outcome measure for people with progressive long term neurological conditions (LTNC). This study aims to determine the psychometric properties of a new 8-item palliative care outcome scale of symptom burden (IPOS Neuro-S8) in this population. Data and Methods Data were merged from a Phase II palliative care intervention study in ...