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Microbial diversity and ecotoxicity of sediments 3 years after the Jiaozhou Bay oil spill

In 2013, the “Qingdao oil pipeline explosion” released an estimated 2000 tons of oil into the environment. Sediment samples were collected from ten sites in Jiaozhou Bay and Shilaoren Beach to evaluate the influence of the spilled oil on the benthic environment 3 years after the oil spill accident. The compositions of oil, bacterial diversity and biotoxicity were examined in this...

Novel Biocompatible Au Nanostars@PEG Nanoparticles for In Vivo CT Imaging and Renal Clearance Properties

Nanoprobes are rapidly becoming potentially transformative tools on disease diagnostics for a wide range of in vivo computed tomography (CT) imaging. Compared with conventional molecular-scale contrast agents, nanoparticles (NPs) promise improved abilities for in vivo detection. In this study, novel polyethylene glycol (PEG)-functionalized Au nanoparticles with star shape (AuNS...

Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease

of Health (P30DK081943 and K08HL130944). Author Contributions Conceptualization: Guisong Wang, Wei Gao, Jifeng Zhang, Y. Eugene Chen, Subramaniam Pennathur. Data curation: Guisong Wang, Anna ... Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun He, Wei Gao, Xiaodan Liu, Yanhong Guo, Jaeman Byun, Jifeng Zhang, Y. Eugene Chen. Formal analysis: Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun

Higher yields of hybrid rice do not depend on nitrogen fertilization under moderate to high soil fertility conditions

Background Increasing rice yield with fewer external inputs is critical to ensuring food security, reducing environmental costs, and improving returns. Use of hybrid rice has expanded greatly in China due to its higher yield potential. Meanwhile, large and increasing amounts of nitrogen (N) fertilizers have been used for expanding rice production in China. It is not clear to what...

Longitudinal validity and reliability of the Myeloma Patient Outcome Scale (MyPOS) was established using traditional, generalizability and Rasch psychometric methods

Purpose The Myeloma Patient Outcome Scale (MyPOS) was developed to measure quality of life in routine clinical care. The aim of this study was to determine its longitudinal validity, reliability, responsiveness to change and its acceptability. Methods This 14-centre study recruited patients with multiple myeloma. At baseline and then every two months for 5 assessments, patients...

Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3

does not have a funding to this research. Author Contributions Conceptualization: Wei Gao, Lihui Zhang, Bin Wang. Data curation: Qi Feng, Jianyao Wang, Xiaoshuo Ye. Formal analysis: Zhihan Li

Elastic–plastic model identification for rock surrounding an underground excavation based on immunized genetic algorithm

To compute the stability of underground engineering, a constitutive model of surrounding rock must be identified. Many constitutive models for rock mass have been proposed. In this model identification study, a generalized constitutive law for an elastic–plastic constitutive model is applied. Using the generalized constitutive law, the problem of model identification is...

The role of adenosinergic pathway in human autoimmune diseases

Autoimmune diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state of appropriate immune response to nonself-antigen and unresponsiveness to self-antigens. In normal situation, immune homeostasis is regulated by immunosuppressive signal and...

Which patients with advanced respiratory disease die in hospital? A 14-year population-based study of trends and associated factors

the GUIDE_Care project: Irene J Higginson (PI), Wei Gao, Julia Verne, Myer Glickman, and Barbara Gomes. Members of the Project Advisory Group (PAG): Tony Bonser, Shaheen Khan, Jonathan Koffman, Katie

Developments in breeding of Agaricus bisporus var. bisporus: progress made and technical and legal hurdles to take

True breeding of button mushrooms has hardly been done in the last decades, despite this species being one of the most cultivated mushrooms worldwide. Research done in the last 20 years has identified and characterised new germplasm and improved our understanding of the genetic base for some traits. A substantial collection of wild-collected strains is now available and partly...

Molecular cloning, characterization and expression analysis of Frizzled 6 in the small intestine of pigs (Sus scrofa)

Frizzled 6 (FZD6) encodes an integral membrane protein that functions in multiple signal transduction pathways, for example, as a receptor in Wnt/planar cell polarity (PCP) signaling pathway for polarized cell migration and organ morphogenesis. Mutations in FZD6 have been identified in a variety of tumors. In this study, the full-length cDNA of Sus scrofa FZD6 (Sfz6) was cloned...

Quorum sensing of microalgae associated marine Ponticoccus sp. PD-2 and its algicidal function regulation

Quorum sensing (QS) systems play important roles in regulating many physiological functions of microorganisms, such as biofilm formation, bioluminescence, and antibiotic production. One marine algicidal bacterium, Ponticoccus sp. PD-2, was isolated from the microalga Prorocentrum donghaiense, and its N-acyl-homoserine lactone (AHL)-mediated QS system was verified. In this study...

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

Background CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and metastasis, but this non-enzymatic function of CD73 in cervical cancer...

Place of death in children and young people with cancer and implications for end of life care: a population-based study in England, 1993–2014

, number of CYP deaths and number of CYP cancer deaths at SCN region level. -: not estimable Acknowledgements The investigators of the GUIDE_Care Children and Young People project: Wei Gao(PI), Irene J

Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells

Heparan sulfate proteoglycans (HSPGs) participate in many processes related to tumor development, including tumorigenesis and metastasis. HSPGs contain one or more heparan sulfate (HS) chains that are covalently linked to a core protein. Glypican-3 (GPC3) is a cell surface-associated HSPG that is highly expressed in hepatocellular carcinoma (HCC). GPC3 is involved in Wnt3a...

Distance-based topological polynomials and indices of friendship graphs

Drugs and chemical compounds are often modeled as graphs in which the each vertex of the graph expresses an atom of molecule and covalent bounds between atoms are represented by the edges between their corresponding vertices. The topological indicators defined over this molecular graph have been shown to be strongly correlated to various chemical properties of the compounds. In...

On Cyber Attacks and Signature Based Intrusion Detection for Modbus Based Industrial Control Systems

Part of the Computer Law Commons; and the Information Security Commons - This work is licensed under a Creative Commons Attribution 4.0 International License. Wei Gao Thom as H. Morri s Department

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

Background Multiple myeloma, the second most common haematological cancer, remains incurable. Its incidence is rising due to population ageing. Despite the impact of the disease and its treatment, not much is known on who is most in need of supportive and palliative care. This study aimed to (a) assess symptom severity, palliative care concerns and health-related quality of life...