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229 papers found.
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High-quality-draft genomic sequence of Paenibacillus ferrarius CY1T with the potential to bioremediate Cd, Cr and Se contamination

Paenibacillus ferrarius CY1T (= KCTC 33419T = CCTCC AB2013369T) is a Gram-positive, aerobic, endospore-forming, motile and rod-shaped bacterium isolated from iron mineral soil. This bacterium reduces sulfate (SO4 2−) to S2−, which reacts with Cd(II) to generate precipitated CdS. It also reduces the toxic chromate [Cr(VI)] and selenite [Se(VI)] to the less bioavailable chromite ...

Variability in the protein profiles in spermatozoa of two sturgeon species

, Qiwei Wei. Data curation: Huamei Yue, Chuangju Li. Formal analysis: Ping Li, Huamei Yue, Chuangju Li. Funding acquisition: Ping Li, Chuangju Li, Qiwei Wei. Investigation: Wei Guo, Hao Du, Xinmei Qiao ... , Zhigang Liu, Qiong Zhou. Project administration: Ping Li, Wei Guo, Qiong Zhou. Resources: Hao Du, Xinmei Qiao, Zhigang Liu. Validation: Ping Li. Visualization: Ping Li. Writing ± original draft: Ping

PD1 is highly expressed in diffuse large B-cell lymphoma with hepatitis B virus infection

Objective The purpose of this study was to determine the association between PD1 expression and the clinical prognosis of diffuse large B-cell lymphoma (DLBCL) co-occurring with hepatitis B virus (HBV) infection. Methods A total of 165 patients presented with newly diagnosed and untreated DLBCL at the First Hospital of Jilin University, Changchun, China, between 2011.01 and ...

XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers

. Project administration: Zhijun Duan, Wuguo Deng. Resources: Miao Chen, Wendan Yu, Wei Guo, Wenlin Huang. Supervision: Zhijun Duan, Wuguo Deng. 16 / 19 Validation: Wuguo Deng. Visualization: Zhifeng Zhang

Genome-wide analysis of brain and gonad transcripts reveals changes of key sex reversal-related genes expression and signaling pathways in three stages of Monopterus albus

Background The natural sex reversal severely affects the sex ratio and thus decreases the productivity of the rice field eel (Monopterus albus). How to understand and manipulate this process is one of the major issues for the rice field eel stocking. So far the genomics and transcriptomics data available for this species are still scarce. Here we provide a comprehensive study of ...

Easy labeling of proliferative phase and sporogonic phase of microsporidia Nosema bombycis in host cells

Microsporidia are eukaryotic, unicellular parasites that have been studied for more than 150 years. These organisms are extraordinary in their ability to invade a wide range of hosts including vertebrates and invertebrates, such as human and commercially important animals. A lack of appropriate labeling methods has limited the research of the cell cycle and protein locations in ...

Functional restoration of CD56bright NK cells facilitates immune control via IL-15 and NKG2D in patients under antiviral treatment for chronic hepatitis B

Chen, Lin Zhu, Aichao Shi, Lin Ding, Xiaoping Zhang, Zhenmin Tan, Wei Guo, Weiming Yan, Meifang Han, Jidong Jia, Xiaoping Luo and Detlef Schuppan have no conflicts of interest to declare. Ethical

Effects upon metabolic pathways and energy production by Sb(III) and As(III)/Sb(III)-oxidase gene aioA in Agrobacterium tumefaciens GW4

Agrobacterium tumefaciens GW4 is a heterotrophic arsenite [As(III)]/antimonite [Sb(III)]-oxidizing strain. The As(III) oxidase AioAB is responsible for As(III) oxidation in the periplasm and it is also involved in Sb(III) oxidation in Agrobacterium tumefaciens 5A. In addition, Sb(III) oxidase AnoA and cellular H2O2 are also responsible for Sb(III) oxidation in strain GW4. However, ...

Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells

Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in PDGF-induced proliferation are unclear. In this study, we demonstrated the roles of Rb/E2F and TSC/mTOR pathways in PDGF-induced proliferation in VSMCs. We found that ...

TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma

The present study demonstrated that T cell factor 1 (TCF-1) protein, a component of the canonical Wnt/β-catenin signaling pathway, can regulate the expression of runt-related transcription factor 2 (runx2) gene and Sry-related HMG box 9 (sox9) gene, which may participate in the differentiation of chondrosarcoma. Dedifferentiated chondrosarcoma (DDCS) is a special variant of ...

What Is the Value of Surgical Intervention for Sacral Metastases?

Objective To investigate the impact of surgery on local control and quality of life for patients with sacral metastases and to determine whether the complications of surgery were acceptable. Methods Curettage for metastatic lesions of the sacrum was performed in 154 patients with obvious sacral nerve compression symptoms between July 1997 and July 2014. Potential risk factors were ...

Asymptotic behavior of solutions to a class of semilinear parabolic equations

This paper concerns the asymptotic behavior of solutions to the homogeneous Neumann exterior problems of a class of semilinear parabolic equations with convection and reaction terms. The critical Fujita exponents theorems are established. It is shown that the global existence and blow-up of solutions depends on the reaction term, the convection term and the spatial dimension. MSC: ...

PET/CT-guided percutaneous biopsy of FDG-avid metastatic bone lesions in patients with advanced lung cancer: a safe and effective technique

Purpose 18F-FDG PET/CT should be performed before a diagnostic biopsy site is chosen in patients with a high clinical suspicion of aggressive, advanced tumour. The aim of this study was to evaluate the safety and efficacy of 18F-FDG PET/CT in guiding biopsy of bone metastases in patients with advanced lung cancer. Methods PET/CT-guided percutaneous core biopsies were performed in ...

Eigenspace-based beamformer using oblique signal subspace projection for ultrasound plane-wave imaging

Background The Eigenspace-based beamformers, by orthogonal projection of signal subspace, can remove a large part of the noise, and provide better imaging contrast upon the minimum variance beamformer. However, wrong estimate of signal and noise component may bring dark-spot artifacts and distort the signal intensity. The signal component and noise and interference components are ...

Understanding and elimination of process defects in narrow gap multi-pass fiber laser welding of ferritic steel sheets of 30 mm thickness

Narrow gap (or groove) laser welding involves multiple layer additive manufacture for the joining of thick-section metallic components. Typical defects include porosity, cracking, lack of fusion to sidewalls, and between layers, and component distortion including the closure of the groove. This study aimed to understand the defect formation mechanisms and factors affecting them, ...

Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence

Background Recently emerging evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair (ReTIAR), and platelets induce epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), leading ultimately to fibrosis. Due to the commonality of cyclic bleeding as in endometriosis, adenomyotic lesions are also ...

The Efficiency of Split Panel Designs in an Analysis of Variance Model

We consider split panel design efficiency in analysis of variance models, that is, the determination of the cross-sections series optimal proportion in all samples, to minimize parametric best linear unbiased estimators of linear combination variances. An orthogonal matrix is constructed to obtain manageable expression of variances. On this basis, we derive a theorem for analyzing ...

Integrating multiple genomic data: sparse representation based biomarker selection for blood pressure

Background Although many genes have been implicated as hypertension candidates, to date, few studies have integrated different types of genomic data for the purpose of biomarker selection. Methods Applying a newly proposed sparse representation based variable selection (SRVS) method to the Genetic Analysis Workshop19 data, we analyzed a combined data set consisting of 11522 gene ...

Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis

Background Growing evidence indicates that endometriosis is an epigenetic disease. Encouragingly, histone deacetylases (HDACs) and DNA methyltransferases have been shown to be promising targets by numerous in vitro studies. However, only a few studies have shown promising effects of HDAC inhibition in preclinical studies in endometriosis. While lysine-specific demethylase 1 (LSD1) ...