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How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease with dysfunctional α-motor neurons in the anterior horn of the spinal cord. SMA is caused by loss (∼95% of SMA cases) or mutation (∼5% of SMA cases) of the survival motor neuron 1 gene SMN1. As the product of SMN1, SMN is a component of the SMN complex, and is also involved in the biosynthesis of the ...

A holographic dual for string theory on AdS3×S3×S3×S1

The CFT dual of string theory on AdS3 × S3 × S3 × S1 is conjectured to be the symmetric orbifold of the \( {\mathcal{S}}_{\kappa } \) theory, provided that one of the two Q 5 ± quantum numbers is a multiple of the other. We determine the BPS spectrum of the symmetric orbifold in detail, and show that it reproduces precisely the BPS spectrum that was recently calculated in ...

The Programming Optimization of Capacitorless 1T DRAM Based on the Dual-Gate TFET

The larger volume of capacitor and higher leakage current of transistor have become the inherent disadvantages for the traditional one transistor (1T)-one capacitor (1C) dynamic random access memory (DRAM). Recently, the tunneling FET (TFET) is applied in DRAM cell due to the low off-state current and high switching ratio. The dual-gate TFET (DG-TFET) DRAM cell with the ...

Dynamics of soil organic carbon mineralization in tea plantations converted from farmland at Western Sichuan, China

: Renhuan Zhu. Formal analysis: Renhuan Zhu, Wei Li. Funding acquisition: Zicheng Zheng, Tingxuan Li, Xizhou Zhang. Investigation: Renhuan Zhu, Zicheng Zheng, Wei Li. Methodology: Zicheng Zheng, Tingxuan ... Zheng, Tingxuan Li. Validation: Renhuan Zhu, Zicheng Zheng. Visualization: Renhuan Zhu. Writing ± original draft: Renhuan Zhu, Wei Li. Writing ± review & editing: Renhuan Zhu, Zicheng Zheng, Tingxuan

CRISPR-FOCUS: A web server for designing focused CRISPR screening experiments

Hanfei Sun, Chenfei Wang, Binbin Wang and Jinzeng Wang for their help on web server deployment and maintenance, and Wenyan Cui for help on plotting and decoConceptualization: Qingyi Cao, Zhi Chen, Wei Li ... , X. Shirley Liu. Formal analysis: Qingyi Cao. Funding acquisition: X. Shirley Liu. Methodology: Qingyi Cao, Jian Ma, Chen-Hao Chen, Han Xu, Wei Li. Software: Qingyi Cao, Jian Ma, Chen-Hao Chen, Han

HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

, Xiaoping Du, Richard D. Kopke. Funding acquisition: Richard D. Kopke. Investigation: Donald Ewert, Ning Hu, Xiaoping Du, Wei Li. Methodology: Xiaoping Du, Chul-Hee Choi. Project administration: Donald ... Ewert. Resources: Donald Ewert. Supervision: Donald Ewert, Richard D. Kopke. Validation: Donald Ewert, Ning Hu, Xiaoping Du, Richard D. Kopke. Visualization: Donald Ewert, Ning Hu, Xiaoping Du, Wei Li

Forced oscillation for solutions of boundary value problems of fractional partial difference equations

In this paper, we obtain the forced oscillation of solutions for certain fractional partial difference equations with two different types of boundary conditions. Our results are based on discrete Gaussian formula and some basic theories of discrete fractional calculus. MSC: 26A33, 39A21, 39A14, 39A12.

Entry-Level Forward Surgical Team Training in 5th Grade Students of Second Military Medical University of the Chinese People’s Liberation Army

technicians, and a healthcare administrator [1–3]. First established as Mobile Army Surgical Hospital (MASH) in Korean War, the unit was thought to be too cumbersome for effectively Shiguan Le, Wang Xi, Wei Li

Applications of the generalised Dirichlet integral inequality to the Neumann problem with fast-growing continuous data

By using the generalised Dirichlet integral inequality with continuous functions on the boundary of the upper half-space, we prove new types of solutions for the Neumann problem with fast-growing continuous data on the boundary. Given any harmonic function with its negative part satisfying similarly fast-growing conditions, we obtain weaker boundary integral condition.

Multilocus genotyping of Giardia duodenalis in captive non-human primates in Sichuan and Guizhou provinces, Southwestern China

: Zhijun Zhong, Yinan Tian, Wei Li. Methodology: Zhijun Zhong, Yinan Tian, Wei Li, Lei Deng, Yi Geng. Project administration: Guangneng Peng. Software: Zhijun Zhong, Yinan Tian, Wei Li, Lei Deng, Liuhong ... Shen, Haifeng Liu. Writing ± original draft: Zhijun Zhong, Yinan Tian. Writing ± review & editing: Zhijun Zhong, Wei Li. 7 / 9 8 / 9 1. Thompson SC . Giardia lamblia in children and the child care

Titanate Nanotubes Decorated Graphene Oxide Nanocomposites: Preparation, Flame Retardancy, and Photodegradation

Most polymers exhibit high flammability and poor degradability, which restrict their applications and causes serious environmental problem like “white pollution.” Thus, titanate nanotubes (TNTs) were adopted to decorate graphene oxide (GO) by a facile solution method to afford TNTs/GO nanocomposites with potential in improving the flame retardancy and photodegradability of flexible ...

Endothelial keratoplasty versus repeat penetrating keratoplasty after failed penetrating keratoplasty: A systematic review and meta-analysis

Project Grant (No. AFI44D11) as well as Hunan Provincial Natural Science Foundation of China (No. 2017JJ2001). Author Contributions Conceptualization: Feng Wang, Shao-Wei Li. Data curation: Tao Zhang ... , Yan Wei Kang, Jing Liang He. Formal analysis: Tao Zhang, Shi-Ming Li. Funding acquisition: Feng Wang, Shao-Wei Li. Methodology: Shi-Ming Li. Project administration: Feng Wang, Shao-Wei Li

Comparison of healthy lifestyle behaviors among individuals with and without cardiovascular diseases from urban and rural areas in China: A cross-sectional study

Questionnaire_CN. (PDF) S4 File. Data set. (SAS7BDAT) Acknowledgments We thank all the investigators participating in the PURE-China study: China Coordination Center Beijing Office: Lisheng Liu , Wei Li (), Hongye ... at each site). Author Contributions Conceptualization: Chuangshi Wang, Wei Li, Lu Yin, Yaguang Peng, Yang Wang. Data curation: Chuangshi Wang, Jian Bo. Formal analysis: Chuangshi Wang. Funding

Higher spins and Yangian symmetries

The relation between the bosonic higher spin \( {\mathcal{W}}_{\infty}\left[\lambda \right] \) algebra, the affine Yangian of \( \mathfrak{g}{\mathfrak{l}}_1 \), and the SHc algebra is established in detail. For generic λ we find explicit expressions for the low-lying \( {\mathcal{W}}_{\infty}\left[\lambda \right] \) modes in terms of the affine Yangian generators, and deduce from ...

Preparation of Alumina Nanorods from Chromium-Containing Alumina Sludge

Alumina nanorods were prepared from chromium-containing alumina sludge, and the effects of doping elements, such as Cr, Fe, and Mg, were researched. The results show that the crystal transformation of alumina is restricted by the doped Cr and facilitated by the doped Fe and Mg, which is transformed from θ-Al2O3 to α-Al2O3 in the calcination process. Meanwhile, the crystal ...

Oscillation results for certain forced fractional difference equations with damping term

In this paper, we establish two sufficient conditions for the oscillation of forced fractional difference equations with damping term of the form ( 1 + p ( t ) ) Δ ( Δ α x ( t ) ) + p ( t ) Δ α x ( t ) + f ( t , x ( t ) ) = g ( t ) , t ∈ N 0 , with initial condition Δ α − 1 x ( t ) | t = 0 = x 0 , where 0 < α < 1 is a constant, Δ α x is the Riemann-Liouville fractional difference ...

Design of High Performance Si/SiGe Heterojunction Tunneling FETs with a T-Shaped Gate

In this paper, a new Si/SiGe heterojunction tunneling field-effect transistor with a T-shaped gate (HTG-TFET) is proposed and investigated by Silvaco-Atlas simulation. The two source regions of the HTG-TFET are placed on both sides of the gate to increase the tunneling area. The T-shaped gate is designed to overlap with N+ pockets in both the lateral and vertical directions, which ...

Does salt stress affect the interspecific interaction between regionally dominant Suaeda salsa and Scirpus planiculumis?

Plant-plant interactions that change along environmental gradients can be affected by different combinations of environmental characteristics, such as the species and planting density ratios. Suaeda salsa and Scirpus planiculumis are regionally dominant species in the Shuangtai estuarine wetland. Compared with non-clonal S. salsa, clonal S. planiculumis has competitive advantages ...

BPS spectrum on AdS3×S3×S3×S1

The BPS spectrum of string theory on AdS3 × S3 × S3 × S1 is determined using a world-sheet description in terms of WZW models. It is found that the theory only has BPS states with j + = j − where j ± refer to the spins of the \( \mathfrak{s}\mathfrak{u}(2) \) algebras of the large \( \mathcal{N} \) = 4 superconformal algebra. We then re-examine the BPS spectrum of the corresponding ...

Oscillation of solutions for certain fractional partial differential equations

In this paper, sufficient conditions are established for the forced oscillation of fractional partial differential equations of the form ∂ ∂ t ( D + , t α u ( x , t ) ) = a ( t ) Δ u ( x , t ) − m ( x , t , u ( x , t ) ) + f ( x , t ) , ( x , t ) ∈ Ω × R + ≡ G , with one of the two following boundary conditions: ∂ u ( x , t ) ∂ N = ψ ( x , t ) , ( x , t ) ∈ ∂ Ω × R + , or u ( x , t ...