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How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease with dysfunctional α-motor neurons in the anterior horn of the spinal cord. SMA is caused by loss (∼95% of SMA cases) or mutation (∼5% of SMA cases) of the survival motor neuron 1 gene SMN1. As the product of SMN1, SMN is a component of the SMN complex, and is also involved in the biosynthesis of the ...

Effect of internal pressure on springback during low pressure tube hydroforming

For the existence of bending deformation during low pressure tube hydroforming(LPTH), springback is unavoidable and deteriorate the forming accuracy. In this paper, an analytical model of springback for LPTH was proposed. The simulation and experiment were carried out to investigate the effects of the main factors on the springback, such as internal pressure, corner radius and ...

Effect of drying procedures on the physicochemical properties and antioxidant activities of polysaccharides from Crassostrea gigas

201405017-030 , to Dr. Wei Li and the National Natural Science Foundation of China , Grant number 31571916, to Dr. Changqing Tong 2 Editor: Reza Khodarahmi, Kermanshah University of Medical Sciences , ISLAMIC ... Tong, Wei Li. Data curation: Sijie Hu, Guanhua Zhao, Changqing Tong, Wei Li. Formal analysis: Sijie Hu, Guanhua Zhao, Wei Li. Funding acquisition: Wei Li. Investigation: Sijie Hu, Yaxu Zheng, Wei Li

Correction: De novo assembly and analysis of the transcriptome of Rumex patientia L. during cold stress

Liu , Yongqing Xu, Liguo Zhang, Wei Li, Zhenxue Cai, Fei Li, Mu Peng, Fenglan Li The affiliations for authors Liguo Zhang and Wei Li are incorrect. Liguo Zhang and Wei Ling are not affiliated with #1

A holographic dual for string theory on AdS3×S3×S3×S1

The CFT dual of string theory on AdS3 × S3 × S3 × S1 is conjectured to be the symmetric orbifold of the \( {\mathcal{S}}_{\kappa } \) theory, provided that one of the two Q 5 ± quantum numbers is a multiple of the other. We determine the BPS spectrum of the symmetric orbifold in detail, and show that it reproduces precisely the BPS spectrum that was recently calculated in ...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of ...

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of ...

Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity

Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and cardiac dysfunction induced by obesity. Six-week-old C57BL6/J mice were fed a high-fat diet (HFD), normal diet (ND), or an HFD supplemented with folic acid (FAD) for 14 weeks. ...

The Programming Optimization of Capacitorless 1T DRAM Based on the Dual-Gate TFET

The larger volume of capacitor and higher leakage current of transistor have become the inherent disadvantages for the traditional one transistor (1T)-one capacitor (1C) dynamic random access memory (DRAM). Recently, the tunneling FET (TFET) is applied in DRAM cell due to the low off-state current and high switching ratio. The dual-gate TFET (DG-TFET) DRAM cell with the ...

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies

analysis: Min Min, Ping Wang, Xiao-Yong Man. Funding acquisition: Sui-Qing Cai, Min Zheng, Xiao-Yong Man. Investigation: Min Min, Bing-Xi Yan, Ping Wang, Jia-Qi Chen, Wei Li. Methodology: Lilla Landeck ... . Resources: Wei Li. Writing ± original draft: Min Min, Xiao-Yong Man. Writing ± review & editing: Min Zheng, Xiao-Yong Man. 19 / 22 20 / 22 21 / 22 1. Singh TP , Schon MP , Wallbrecht K , Gruber-Wackernagel

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. We performed in vivo two-photon calcium imaging to examine the activities of ...

Dynamics of soil organic carbon mineralization in tea plantations converted from farmland at Western Sichuan, China

: Renhuan Zhu. Formal analysis: Renhuan Zhu, Wei Li. Funding acquisition: Zicheng Zheng, Tingxuan Li, Xizhou Zhang. Investigation: Renhuan Zhu, Zicheng Zheng, Wei Li. Methodology: Zicheng Zheng, Tingxuan ... Zheng, Tingxuan Li. Validation: Renhuan Zhu, Zicheng Zheng. Visualization: Renhuan Zhu. Writing ± original draft: Renhuan Zhu, Wei Li. Writing ± review & editing: Renhuan Zhu, Zicheng Zheng, Tingxuan

Effects of biomass reducing agent on magnetic properties and phase transformation of Baotou low-grade limonite during magnetizing-roasting

: Hui juan Luo. Investigation: Wen chao Guo. Methodology: Wen fei Wu. Project administration: Kai Zhang. Software: Zhi jun Gong. Supervision: Bao wei Li. 1. Bing HU , Huang ZC , Tao J , Xia W , Zhang

Characterization of microRNAs of Beta macrocarpa and their responses to Beet necrotic yellow vein virus infection

-Liang Zhang, Cheng-Gui Han. Resources: Da-Wei Li, Jia-Lin Yu. Validation: Jun-Ying Liu, Hui-Yan Fan. Writing ± original draft: Jun-Ying Liu. Writing ± review & editing: Yong-Liang Zhang, Cheng-Gui Han

De novo assembly and analysis of the transcriptome of Rumex patientia L. during cold stress

expressed gene). (DOC) Author Contributions Formal analysis: Liguo Zhang, Wei Li, Zhenxue Cai, Fei Li, Mu Peng. Project administration: Fenglan Li, Baozhong Hu. Writing ± original draft: Jianxin Liu

CRISPR-FOCUS: A web server for designing focused CRISPR screening experiments

Hanfei Sun, Chenfei Wang, Binbin Wang and Jinzeng Wang for their help on web server deployment and maintenance, and Wenyan Cui for help on plotting and decoConceptualization: Qingyi Cao, Zhi Chen, Wei Li ... , X. Shirley Liu. Formal analysis: Qingyi Cao. Funding acquisition: X. Shirley Liu. Methodology: Qingyi Cao, Jian Ma, Chen-Hao Chen, Han Xu, Wei Li. Software: Qingyi Cao, Jian Ma, Chen-Hao Chen, Han

Prevalence and molecular characterization of Giardia intestinalis in racehorses from the Sichuan province of southwestern China

giardiasis, and effective strategies and measures should be implemented to control its transmission from racehorses to humans. Author Contributions Conceptualization: Wei Li, Ya Wang, Guangneng Peng. Data ... curation: Lei Deng, Wei Li, Yuan Song, Hualin Fu. Formal analysis: Wei Li, Yijun Chai, Yanchun Hu. Investigation: Lei Deng, Xue Luo, Yuan Song, Suizhong Cao, Guangneng Peng. Methodology: Lei Deng, Zhijun

Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel

Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of prostate cancer (PC) cells to docetaxel-induced apoptosis. Hence, there is an urgent need to identify mechanisms of docetaxel chemoresistance and to develop new combination therapies. miR-193a-5p level was evaluated by qPCR in prostate tissues and cell lines, and its ...

Forced oscillation for solutions of boundary value problems of fractional partial difference equations

In this paper, we obtain the forced oscillation of solutions for certain fractional partial difference equations with two different types of boundary conditions. Our results are based on discrete Gaussian formula and some basic theories of discrete fractional calculus. MSC: 26A33, 39A21, 39A14, 39A12.

Applications of the generalised Dirichlet integral inequality to the Neumann problem with fast-growing continuous data

By using the generalised Dirichlet integral inequality with continuous functions on the boundary of the upper half-space, we prove new types of solutions for the Neumann problem with fast-growing continuous data on the boundary. Given any harmonic function with its negative part satisfying similarly fast-growing conditions, we obtain weaker boundary integral condition.