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Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and ...

Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations

Background Clostridium pasteurianum is becoming increasingly attractive for the production of chemicals and fuels such as n-butanol and 1,3-propanediol. Previously we have shown that dual substrate fermentation using glucose and glycerol enhanced the cell growth and butanol production significantly. Although C. pasteurianum can grow efficiently with either glucose or glycerol ...

Seroprevalence and Associated Factors of 9-Valent Human Papillomavirus (HPV) Types among Men in the Multinational HIM Study

Background Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Recently a 9-valent HPV (9vHPV) prophylactic vaccine was licensed. Seroprevalence prior to vaccine dissemination is needed for monitoring vaccine effectiveness over time. Few studies have assessed the seroprevalence of 9vHPV types in men. Objectives To investigate the ...

Trapping and Driving Individual Charged Micro-particles in Fluid with an Electrostatic Device

A variety of micro-tweezers techniques, such as optical tweezers, magnetic tweezers, and dielectrophoresis technique, have been applied intensively in precise characterization of micro/nanoparticles and bio-molecules. They have contributed remarkably in better understanding of working mechanisms of individual sub-cell organelles, proteins, and DNA. In this paper, we present a ...

Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes

Background To report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT). Methods One hundred and forty-six healthy volunteers were consecutively recruited for this prospective observational study. Thickness of retina, RGC-related layers, and choroid in the standard early ...

B s → K (*)ℓ \( \overline{\nu} \) , angular analysis, S-wave contributions and |V ub |

Ulf-G. Meiner 0 1 Wei Wang 1 0 Institute for Advanced Simulation, Institut fur Kernphysik and Julich Center for Hadron Physics , JARA-FAME and JARA-HPC, Forschungszentrum Julich, D-52425 Julich

Production of the bottom analogs and the spin partner of the X(3872) at hadron colliders

Using the Monte Carlo event generator tools Pythia and Herwig, we simulate the production of bottom/charm meson and antimeson pairs at hadron colliders in proton–proton/antiproton collisions. With these results, we derive an order-of-magnitude estimate for the production rates of the bottom analogs and the spin partner of the \(X(3872)\) as hadronic molecules at the LHC and ...

Production of charm-strange hadronic molecules at the LHC

We explore the inclusive hadroproduction of the \( D_{s0}^{*}\left( {2317} \right) \), D s1(2460) and D sJ (2860) states at the Large Hadron Collider under the assumption that these hadrons are S-wave meson-meson molecules. In addition, the D s2(2910), a predicted bound state of the D 2(2460)K system, is also discussed. We first derive a factorisation formula for the production ...

iSubgraph: Integrative Genomics for Subgroup Discovery in Hepatocellular Carcinoma Using Graph Mining and Mixture Models

The high tumor heterogeneity makes it very challenging to identify key tumorigenic pathways as therapeutic targets. The integration of multiple omics data is a promising approach to identify driving regulatory networks in patient subgroups. Here, we propose a novel conceptual framework to discover patterns of miRNA-gene networks, observed frequently up- or down-regulated in a group ...

Mating system shifts and transposable element evolution in the plant genus Capsella

Background Despite having predominately deleterious fitness effects, transposable elements (TEs) are major constituents of eukaryote genomes in general and of plant genomes in particular. Although the proportion of the genome made up of TEs varies at least four-fold across plants, the relative importance of the evolutionary forces shaping variation in TE abundance and distributions ...

Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton

Background Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved ...

Addressing RNA Integrity to Determine the Impact of Mitochondrial DNA Mutations on Brain Mitochondrial Function with Age

Mitochondrial DNA (mtDNA) mutations can result in mitochondrial dysfunction, but emerging experimental data question the fundamental role of mtDNA mutagenesis in age-associated mitochondrial impairment. The multicopy nature of mtDNA renders the impact of a given mtDNA mutation unpredictable. In this study, we compared mtDNA stability and mtRNA integrity during normal aging. Seven ...

Hunting for a scalar glueball in exclusive B decays

Although glueballs, as one of the type of exotic hadrons allowed by QCD, have been well established on the lattice, experimental searches up to this date for bound states of gluons have only produced controversial signals. In this work, using flavor SU(3) symmetry for the light quarks validated by the available experimental data, we propose an intuitive way to hunt for a scalar ...

Pollution plumes observed by aircraft over North China during the IPAC-NC field campaign

Strong pollution emissions from large urban and industrial centres in eastern China are thought to greatly impact regional air quality and global atmospheric chemistry. In this study, we investigate extensive pollution plumes over North China, observed by aircraft during the IPAC-NC (Influence of Pollution on Aerosols and Cloud Microphysics in North China) field campaign in spring ...

Prevalence and Associated Factors of Myopia in High-School Students in Beijing

Purpose To evaluate prevalence and associated factors for myopia in high school students in Beijing. Methods Grade 10 and 11 high school students were randomly selected from nine randomly selected districts of Beijing. The students underwent non-cylcoplegic auto-refractometry and an interview. Results Out of 4798 eligible students, 4677 (93.4%) students (mean ...

IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization

Choroidal neovascularization (CNV) is aberrant angiogenesis associated with exudative age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Inflammation has been suggested as a risk factor for AMD. The IKK2/NF-κB pathway plays a key role in the inflammatory response through regulation of the transcription of cytokines, chemokines, growth factors and ...

Scientific publications in ophthalmic journals from China and other top-ranking countries: a 12-year review of the literature

Background Eye diseases with increasing mortality are common health problems that affect people of all ages and demographic backgrounds. In this study, we study the publication characteristics in international ophthalmic journals of the US, the UK, Germany, Australia, Japan, and China. Methods Articles published in 53 ophthalmic journals from 2000 to 2011 were retrieved from the ...