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Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and ...

Joint spectrum sensing and access for stable dynamic spectrum aggregation

Spectrum aggregation is an emerging technology to satisfy the data rate requirement of broadband services for next-generation wireless communication systems. In dynamic spectrum environment, in which the spectrum availability is time-varying, it is quite challenging to maintain the stability of spectrum aggregation. In this paper, we investigate the spectrum sensing and access ...

The First Comprehensive Phylogeny of Coptis (Ranunculaceae) and Its Implications for Character Evolution and Classification

Coptis (Ranunculaceae) contains 15 species and is one of the pharmaceutically most important plant genera in eastern Asia. Understanding of the evolution of morphological characters and phylogenetic relationships within the genus is very limited. Here, we present the first comprehensive phylogenetic analysis of the genus based on two plastid and one nuclear markers. The phylogeny ...

Editorial for the Special Issue: Green Cognitive and Cooperative Communication and Networking

, Green Cooperative Cognitive Communication and Networking: A New Paradigm for Wireless Networks, the authors (Lin Chen, Wei Wang, Alagan S. Anpalagan, Athanasios V. Vasilakos, Kandasamy Illanko, Honggang ... conferences on networking and communications. Dr. Wei Wang received his B.S. degree in Communication Engineering and Ph.D. degree in Signal and Information Processing in 2004 and 2009, respectively, both from

Genome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci

data. QR, PR, FS, FV, LM and XWW drafted the manuscript. All authors read and approved the final manuscript. Authors’ information Laurence Mouton and Xiao-Wei Wang are last co-authors. Acknowledgements ... Wang 2 0 Equal contributors 1 Université de Lyon, Université Lyon1, Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 558 , 69622 Villeurbanne, Cedex , France 2 Ministry of Agriculture Key

Two Host Clades, Two Bacterial Arsenals: Evolution through Gene Losses in Facultative Endosymbionts

Bacterial endosymbiosis is an important evolutionary process in insects, which can harbor both obligate and facultative symbionts. The evolution of these symbionts is driven by evolutionary convergence, and they exhibit among the tiniest genomes in prokaryotes. The large host spectrum of facultative symbionts and the high diversity of strategies they use to infect new hosts ...

Corticomotor control of the genioglossus in awake OSAS patients: a transcranial magnetic stimulation study

subjects, data collection and analysis, and the subjects for their participation in the study. Wei Wang is a visiting scholar from Institute of Respiratory Disease, The 1st Affiliated Hospital of China

Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009–2010

To determine the role of the pandemic influenza A/H1N1 2009 (A/H1N1 2009pdm) in acute respiratory tract infections (ARTIs) and its impact on the epidemic of seasonal influenza viruses and other common respiratory viruses, nasal and throat swabs taken from 7,776 patients with suspected viral ARTIs from 2006 through 2010 in Beijing, China were screened by real-time PCR for influenza ...

High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice

G protein-coupled receptor 119 (GPR119) is highly expressed in pancreatic β cells and enteroendocrine cells. It is involved in glucose-stimulated insulin secretion and glucagon-like peptide-1 (GLP-1) release, thereby representing a promising target for the treatment of type 2 diabetes. Although a number of GPR119 agonists were developed, no positive allosteric modulator (PAM) to ...

Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data

Accurate determination of circadian phase is necessary for research and clinical purposes because of the influence of the master circadian pacemaker on multiple physiologic functions. Melatonin is presently the most accurate marker of the activity of the human circadian pacemaker. Current methods of analyzing the plasma melatonin rhythm can be grouped into three categories: ...

Complete genome sequence of human astrovirus genotype 6

Background Human astroviruses (HAstVs) are one of the important causes of acute gastroenteritis in children. Currently, eight HAstV genotypes have been identified and all but two (HAstV-6 and HAstV-7) have been fully sequenced. We here sequenced and analyzed the complete genome of a HAstV-6 strain (192-BJ07), which was identified in Beijing, China. Results The genome of 192-BJ07 ...

Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin – a case–control study

Background Non-melanoma skin cancer (NMSC), comprised of basal (BCC) and squamous (SCC) cell carcinomas, is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental risk factor for NMSC. However, the precise relationship between UVR and the risk of NMSC is complex, and the relationship may differ by skin cancer type. Methods A ...

Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection

Background Human rhinoviruses (HRVs) are a highly prevalent cause of acute respiratory infection in children. They are classified into at least three species, HRV-A, HRV-B and HRV-C, which are characterized by sequencing the 5′ untranslated region (UTR) or the VP4/VP2 region of the genome. Given the increased interest for novel HRV strain identification and their worldwide ...

A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm

Background Intrabodies are defined as antibody molecules which are ectopically expressed inside the cell. Such intrabodies can be used to visualize or inhibit the targeted antigen in living cells. However, most antibody fragments cannot be used as intrabodies because they do not fold under the reducing conditions of the cell cytosol and nucleus. Results We describe the construction ...

Chromosome 7p11.2 (EGFR) variation influences glioma risk

Carpentier Xiao-Wei Wang Anna Luisa Di Stefano Marianne Labussie` re Konstantinos Gousias Johannes Schramm Anne Boland Doris Lechner Ivo Gut Georgina Armstrong Yanhong Liu Robert Yu Ching Lau Maria Chiara Di