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18 papers found.
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Comparing the Safety and Efficacy of Celecoxib for the Treatment of Osteoarthritis in Asian and non-Asian Populations: An Analysis of Data from Two Randomized, Double-blind, Placebo-controlled, Active-comparator Trials

for the integrity of the work as a whole, and have given final approval to the version to be published. Disclosures. Andri Lubis has nothing to disclose. Wei Wang has received consultancy fees from

Special issue on resilience in steel structures

Structures”. Guest Editors Wei Wang Professor, Tongji University, China E-mail: Tak-Ming Chan Assistant Professor, The Hong Kong Polytechnic University, Hong Kong SAR, China Yunfeng Zhang Professor, University

Re-Identification Risk versus Data Utility for Aggregated Mobility Research Using Mobile Phone Location Data

Mobile phone location data is a newly emerging data source of great potential to support human mobility research. However, recent studies have indicated that many users can be easily re-identified based on their unique activity patterns. Privacy protection procedures will usually change the original data and cause a loss of data utility for analysis purposes. Therefore, the need...

The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice

Oxytocin has been suggested as a promising new treatment for neurodevelopmental disorders. However, important gaps remain in our understanding of its mode of action, in particular, to what extent oxytocin modulates social and non-social behaviours and whether its effects are generalizable across both sexes. Here we investigated the effects of a range of oxytocin doses on social...

African schistosomiasis in mainland China: risk of transmission and countermeasures to tackle the risk

Schistosomiasis is a major disease of public health importance in humans occurring in 76 countries of the tropics and sub-tropics. In China, schistosomiasis japonica is one of the highest priorities in communicable disease control defined by the central government. Since 1970s, the habitats of Biomphalaria straminea, an intermediate host of Schistosoma mansoni in South America...

Fast subcellular localization by cascaded fusion of signal-based and homology-based methods

Background The functions of proteins are closely related to their subcellular locations. In the post-genomics era, the amount of gene and protein data grows exponentially, which necessitates the prediction of subcellular localization by computational means. Results This paper proposes mitigating the computation burden of alignment-based approaches to subcellular localization...

The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets

Background Neuraminidase (NA) inhibitors are the only licensed therapeutic option for human zoonotic H7N9 infections. An NA-R292K mutation that confers broad-spectrum resistance to NA inhibitors has been documented in H7N9 patients after treatment.

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing

Background Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a sesquiterpene lactone, is produced in glandular trichomes of Artemisia annua. However, only limited genomic information is currently available in this non-model plant species. Results We present a global...

Explaining employees' Extended Use of complex information systems

others. Wei Wang is a Ph.D. candidate at the Hong Kong Polytechnic University. Her research focuses on IT adoption and post-adoption, IS implementation, and E-commerce. Her research has been accepted by

PSCC: Sensitive and Reliable Population-Scale Copy Number Variation Detection Method Based on Low Coverage Sequencing

Background Copy number variations (CNVs) represent an important type of genetic variation that deeply impact phenotypic polymorphisms and human diseases. The advent of high-throughput sequencing technologies provides an opportunity to revolutionize the discovery of CNVs and to explore their relationship with diseases. However, most of the existing methods depend on sequencing...

The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population

CLEC4M is a C-type lectin gene serving as cell adhesion receptor and pathogen recognition receptor. It recognizes several pathogens of important public health concern. In particular, a highly polymorphic variable number tandem repeat (VNTR) at the neck-region of CLEC4M had been associated with genetic predisposition to some infectious diseases. To gain insight into the origin and...

Repressive Effect of Primary Virus Replication on Superinfection Correlated with Gut-Derived Central Memory CD4+ T Cells in SHIV-Infected Chinese Rhesus Macaques

A possible mechanism of susceptibility to superinfection with simian-human immunodeficiency virus (SHIV)-1157ipd3N4 was explored in twelve SHIVSF162P3-infected Chinese rhesus macaques. Based on the kinetics of viral replication for the second infecting virus following SHIV-1157ipd3N4 inoculation, the monkeys were divided into two groups: those relatively resistant to...

A MicroRNA-7 Binding Site Polymorphism in HOXB5 Leads to Differential Gene Expression in Bladder Cancer

Purpose To investigate the biological function of HOXB5 in human bladder cancer and explore whether the HOXB5 3′-UTR SNP (1010A/G), which is located within the microRNA-7 binding site, was correlated with clinical features of bladder cancer. Methods Expression of HOXB5 in 35 human bladder cancer tissues and 8 cell lines were examined using real-time PCR and immunohistochemistry...

Development and promotion in translational medicine: perspectives from 2012 sino-american symposium on clinical and translational medicine

out in the United States and extended to Europe and potentially China [9]. Dr. Wei Wang, Professor of School of Medical Sciences, Edith Cowan University, Perth, Australia, and he is also the Dean of

Prenatal Detection of Aneuploidy and Imbalanced Chromosomal Arrangements by Massively Parallel Sequencing

Fetal chromosomal abnormalities are the most common reasons for invasive prenatal testing. Currently, G-band karyotyping and several molecular genetic methods have been established for diagnosis of chromosomal abnormalities. Although these testing methods are highly reliable, the major limitation remains restricted resolutions or can only achieve limited coverage on the human...

The international effort: building the bridge for Translational Medicine: Report of the 1st International Conference of Translational Medicine (ICTM)

chronic diseases or diseases at their early stage such as seen in many cancer types. Professor Wei Wang, MD, PhD, from Edith Cowan University, Perth, Australia, Chinese Academy of Sciences and Capital

Efficient Simulation of the Spatial Transmission Dynamics of Influenza

Early data from the 2009 H1N1 pandemic (H1N1pdm) suggest that previous studies over-estimated the within-country rate of spatial spread of pandemic influenza. As large spatially resolved data sets are constructed, the need for efficient simulation code with which to investigate the spatial patterns of the pandemic becomes clear. Here, we present a significant improvement to the...