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23 papers found.
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Porous yet dense metal-free electro-materials for compact energy storage

Metal-free electro-materials, made of mainly conjugated carbon atoms as well as other elements, allow the development of abundant porosity and good conductivity. Most importantly, metal-free electro-materials are preferential in terms of sustainability, chemical variety and processability. Nevertheless the challenge of using metal-free materials is to increase the density. ...

Emerging roles of NudC family: from molecular regulation to clinical implications

Nuclear distribution gene C (NudC) was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mammalian homolog is Lissencephaly 1 (Lis1). NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs: NudC, NudC-like protein (NudCL), and NudC-like protein 2 (NudCL2). All members of the NudC family share a conserved p23 domain, which possesses ...

Establishing guidelines for CAR-T cells: challenges and considerations

T cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, ...

Insights into the function of tegument proteins from the varicella zoster virus

Chickenpox (varicella) is caused by primary infection with varicella zoster virus (VZV), which can establish long-term latency in the host ganglion. Once reactivated, the virus can cause shingles (zoster) in the host. VZV has a typical herpesvirus virion structure consisting of an inner DNA core, a capsid, a tegument, and an outer envelope. The tegument is an amorphous layer ...

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are ...

Analysis of plastid and nuclear DNA data in plant phylogenetics—evaluation and improvement

Correct combination of plastid (cp) and nuclear (nr) DNA data for plant phylogenetic reconstructions is not a new issue, but with an increasing number of nrDNA loci being used, it is of ever greater practical concern. For accurately reconstructing the phylogeny and evolutionary history of plant groups, correct treatment of phylogenetic incongruence is a vital step in the proper ...

Learnability of multi-instance multi-label learning

Multi-instance multi-label learning (MIML) is a new machine learning framework where one data object is described by multiple instances and associated with multiple class labels. During the past few years, many MIML algorithms have been developed and many applications have been described. However, there lacks theoretical exploration to the learnability of MIML. In this paper, ...

ATHK1 acts downstream of hydrogen peroxide to mediate ABA signaling through regulation of calcium channel activity in Arabidopsis guard cells

Plants gradually develop their ability to tolerate environmental water deficit as part of the evolutionary process. Abscisic acid (ABA) plays a critical role during drought and osmotic stress. Several histidine protein kinases are regarded as osmotic sensors or regulators in the adaptive response of plants to water deficit. In this study, we report that ATHK1, which was previously ...

Sumoylation of hypoxia inducible factor-1α and its significance in cancer

Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid tumors. The transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of HIF-1α, an oxygen-sensitive subunit of HIF-1, are mainly modulated by various ...

Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L

We recently report that the expression of polycomb chromobox 4 (Cbx4) is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma (HCC) patients and it enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha (HIF-1α). Here we ...

Dynamic prediction of building subsidence deformation with data-based mechanistic self-memory model

This paper describes a building subsidence deformation prediction model with the self-memorization principle. According to the non-linear specificity and monotonic growth characteristics of the time series of building subsidence deformation, a data-based mechanistic self-memory model considering randomness and dynamic features of building subsidence deformation is established based ...

Pollution plumes observed by aircraft over North China during the IPAC-NC field campaign

Strong pollution emissions from large urban and industrial centres in eastern China are thought to greatly impact regional air quality and global atmospheric chemistry. In this study, we investigate extensive pollution plumes over North China, observed by aircraft during the IPAC-NC (Influence of Pollution on Aerosols and Cloud Microphysics in North China) field campaign in spring ...

The Sixth Sino-US Chemistry Professors Conference: A catalyst for interaction and collaboration

were reported. In the conference banquet ceremony, Professors LiHe Zhang, Zhen Huang and Wei Wang announced and conferred the 2010 CAPA distinguished awards for scientific accomplishment to Professors ... , Wei Wang, director, Xi Chen, and secretary, Qian Wang, have been elected to lead CAPA. Finally, please join us in thanking the past CAPA president Professor Zhen Huang for his excellent leadership

Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment

A couple with a proband child of GJB2 (encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis (PGD), ...

The Lantian biota: A new window onto the origin and early evolution of multicellular organisms

The Lantian biota at the Lantian Town of Xiuning County, Anhui Province, is preserved in black shales of the Ediacaran Lantian Formation. It yields some of the oldest known complex macroorganisms, including fan-shaped seaweeds and possible animal fossils with tentacles and intestinal-like structures reminiscent of modern coelenterates and bilaterians. The Lantian Lagerstätte sheds ...

Experimental optimization of phase noise performance of optoelectronic oscillator based on directly modulated laser

The experimental optimization of a 10 GHz optoelectronic oscillator (OEO) based on a 1.55 μm directly modulated distributed feedback (DFB) laser is demonstrated in this paper. The phase noise of the directly modulated laser (DML) based OEO is significantly reduced by proper selection of the laser’s bias current and by using a dispersion shifted fiber as a delay line. The phase ...