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Analysis of the Negative-SET Behaviors in Cu/ZrO2/Pt Devices

Metal oxide-based electrochemical metallization memory (ECM) shows promising performance for next generation non-volatile memory. The negative-SET behavior has been observed in various oxide-based ECM devices. But the underlying mechanism of this behavior remains unaddressed and the role of the metal cation and oxygen vacancy in this behavior is unclear. In this work, we have ...

Functional significance of macrophages in pancreatic cancer biology

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease that is usually diagnosed at late stage with few effective therapies. Despite the rapid progress on the genomics and proteomics of the neoplastic cells, therapies that targeted the pancreatic cancer cells proved to be inefficient, which promoted the researchers to turn their attentions to the microenvironment. Currently, ...

Moderate grazing promotes genetic diversity of Stipa species in the Inner Mongolian steppe

Context Disturbances may affect the spatial patterns of plant genetic diversity, but these effects are not yet well understood for lack of direct experimental evidence. Grazing is one of such environmental disturbance factors which may lead to small-scale spatial heterogeneity in natural grasslands. Objectives Our main goal was to determine whether a grazing disturbance alters ...

Application of multispectral imaging in quantitative immunohistochemistry study of breast cancer: a comparative study

Multispectral imaging (MSI) based on imaging and spectroscopy, as relatively novel to the field of histopathology, has been used in biomedical multidisciplinary researches. We analyzed and compared the utility of multispectral (MS) versus conventional red–green–blue (RGB) images for immunohistochemistry (IHC) staining to explore the advantages of MSI in clinical-pathological ...

Physiological mechanism for the reduction in soil water in poplar (Populus deltoides) plantations in Dongting Lake wetlands

The use of large-scale tree plantations has provoked increasing concern regarding the negative effects on local environments in different ecosystems. However, the physiological mechanism underlying the reduction in soil water by tree plantations in wetlands is not clear. The aims of this study were to investigate the effects of poplar (Populus deltoides) plantations on soil water ...

Chaetomium-like fungi causing opportunistic infections in humans: a possible role for extremotolerance

Members of the family Chaetomiaceae are ubiquitous ascosporulating fungi commonly, which reside in soil enriched with manure or cellulosic materials. Their role as human pathogens is largely ignored. However, the ability of some species to grow at high temperature enables them to play an important role as opportunistic pathogens. The family contains several genera and species that ...

Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction

Both cell therapy and angiogenic growth factor gene therapy have been applied to animal studies and clinical trials. Little is known about the direct comparison between cell therapy and angiogenic growth factor gene therapy. The goal of this study was to compare the effects of human bone marrow-derived mesenchymal stem cells (hMSCs) transplantation and injection of angiogenic ...

Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells

Hyperbaric oxygen (HBO) is increasingly used in a number of areas of medical practice, such as selected problem infections and wounds. The beneficial effects of HBO in treating ischemia-related wounds may be mediated by stimulating angiogenesis. We sought to investigate VEGF, the main angiogenic regulator, regulated by HBO in human umbilical vein endothelial cells (HUVECs). In this ...