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A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Background β-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s disease (AD) development, and Aβ monomers have normal physiological function. The antibodies or vaccines against Aβ monomers have serious problems, such as side effects and low curative effects. Therefore, it is essential to specifically target Aβ oligomers rather than monomers for the ...

An adaptive relay node selection algorithm based on opportunity

The collaborative relay network plays an important role in a smart grid application thanks to its high efficiency. However, energy and bandwidth management need to be further improved to extend network life cycle and reduce potential network segmentation. Aiming to balance the network energy consumption, this paper proposes an adaptive relay node selection algorithm based on the ...

Robust optimization for volume variation in timber processing

Volume variation is an uncertainty element which affects timber processing. We studied the volume variation of logs caused by quality defects in traditional timber processing and set up an optimization approach, using a robust optimization method. We used total number of acceptable boards produced to study the relationship between board thickness and raw material logs, using a ...

Particle segmentation algorithm for flexible single particle reconstruction

As single particle cryo-electron microscopy has evolved to a new era of atomic resolution, sample heterogeneity still imposes a major limit to the resolution of many macromolecular complexes, especially those with continuous conformational flexibility. Here, we describe a particle segmentation algorithm towards solving structures of molecules composed of several parts that are ...

Editorial: Mobile Multimedia Communications

Shaanxi Province, China in 2011; and SisuAward, Nokia Research Center, Helsinki in 2010. She is a senior member of IEEE. Wei Wang (M’10 – SM’16) received the Ph.D. degree in computer engineering from the

Reduction behavior and kinetics of vanadium–titanium sinters under high potential oxygen enriched pulverized coal injection

between 20.4 and 23.2 kJ/mol. Corresponding author: Guang-wei Wang E-mail: © The Author(s) 2017. This article is published with open access at link.springer.com ore reduction; sintering; oxygen enrichment

Two-step Structural Design of Mesh Antennas for High Beam Pointing Accuracy

degree from Xidian University, China, in 2006. His research interests include mechanical analysis, optimization and control of flexible structures. Tel: +86-2988203040; E-mail: Wei WANG, born in 1980, is

Effect of Facet Displacement on Radiation Field and Its Application for Panel Adjustment of Large Reflector Antenna

) 5. WANG Meng, WANG Wei, WANG Congsi , et al. A practical approach to evaluate the effects of machining errors on the electrical performance of reflector antennas based on paneled forms [J]. IEEE ... G , MACMARTIN D G , NELSON J , et al. Control and alignment of segmented-mirror telescopes: matrices, modes, and error propagation [J]. Applied Optics, 2004 , 43 ( 6 ): 1223 - 1232 . Wei WANG , born

Coupling Modeling for Functional Surface of Electronic Equipment

antennas and so on. E-mail: Wei WANG born in 1980, is currently an Associate Professor at Key Laboratory of Electronic Equipment Structure Design of Ministry of Education, Xidian University, China. He

Pre-computed Region Guardian Sets Based Reverse kNN Queries

all existed algorithms. Acknowledgements Research of Wei Wang is supported by ARC DP130103401 and DP130103405. Muhammad Aamir Cheema is supported by ARC DE130101002 and DP130103405. Open Access This

The chimeric Japanese encephalitis/Dengue 2 virus protects mice from challenge by both dengue virus and JEV virulent virus

funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Jian Yang, Huiqiang Yang, Zhushi Li, Hua Lin, Yu Zhao, Wei Wang, Shuai Tan, Xianwu

Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

Background Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney disease (CKD) patients in developed countries, limited information is available about CVD prevalence and risk factors in the Chinese CKD population. The Chinese Cohort of Chronic Kidney Disease (C-STRIDE) was established to investigate the prevalence and risk factors of CVD among ...

Kinetics of transcription initiation directed by multiple cis-regulatory elements on the glnAp2 promoter

Transcription initiation is orchestrated by dynamic molecular interactions, with kinetic steps difficult to detect. Utilizing a hybrid method, we aim to unravel essential kinetic steps of transcriptional regulation on the glnAp2 promoter, whose regulatory region includes two enhancers (sites I and II) and three low-affinity sequences (sites III-V), to which the transcriptional ...

Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

Background Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antitumor agents were employed in the design of anti-tumor drugs. To further improve the anti-tumor activity of GA and CA derivatives, a series of novel compounds were ...

Robust group compressive sensing for DOA estimation with partially distorted observations

In this paper, we propose a robust direction-of-arrival (DOA) estimation algorithm based on group sparse reconstruction algorithm utilizing signals observed at multiple frequencies. The group sparse reconstruction scheme for DOA estimation is solved through the complex multitask Bayesian compressive sensing algorithm by exploiting the group sparse property of the received ...

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

, Mengjie Liu, Xizi Chen, Min Huang, Dan Tan, Meng-Qiu Dong, Catherine C. L. Wong, Jiawei Wang, Yanhui Xu and Hong-Wei Wang declare that they have no conflict of interest. This article does not contain any

Analysis of the Negative-SET Behaviors in Cu/ZrO2/Pt Devices

Metal oxide-based electrochemical metallization memory (ECM) shows promising performance for next generation non-volatile memory. The negative-SET behavior has been observed in various oxide-based ECM devices. But the underlying mechanism of this behavior remains unaddressed and the role of the metal cation and oxygen vacancy in this behavior is unclear. In this work, we have ...

Analysis of the Negative-SET Behaviors in Cu/ZrO2/Pt Devices

Metal oxide-based electrochemical metallization memory (ECM) shows promising performance for next generation non-volatile memory. The negative-SET behavior has been observed in various oxide-based ECM devices. But the underlying mechanism of this behavior remains unaddressed and the role of the metal cation and oxygen vacancy in this behavior is unclear. In this work, we have ...