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High level expression of bikunin in Pichia pastoris by fusion of human serum albumin

Bikunin is a proteoglycan exhibiting broad-spectrum inhibitory activity against serine proteases and could potentially suppress tumor cell invasion and metastasis. Here, we have successfully expressed recombinant human bikunin (rh-bikunin) in Pichia pastoris and also established the purification procedure. Different fusion genes of h-UTI and domain I, domain I and domain II, domain ...

Plate/shell topological optimization subjected to linear buckling constraints by adopting composite exponential filtering function

In this paper, a model of topology optimization with linear buckling constraints is established based on an independent and continuous mapping method to minimize the plate/shell structure weight. A composite exponential function (CEF) is selected as filtering functions for element weight, the element stiffness matrix and the element geometric stiffness matrix, which recognize the ...

Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Breast Cancer Risk in a Multiethnic Population

Considerable evidence indicates that vitamin D may reduce the risk of several cancers, including breast cancer. This study examined associations of breast cancer with sun exposure, the principal source of vitamin D, and vitamin D receptor gene (VDR) polymorphisms (FokI, TaqI, BglI) in a population-based case-control study of Hispanic, African-American, and non-Hispanic White women ...

From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and ...

Comparison of the 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer: Results of a Chinese Single-Institution Study of 1,503 Patients

Aim To evaluate the prognostic efficacy of the 7th edition tumor–node–metastasis (TNM) classification compared with the 6th edition in gastric cancer patients. Methods A total of 1,503 gastric cancer patients undergoing surgical resection were staged using the 6th and 7th edition staging systems. Homogeneity, discriminatory ability, and monotonicity of gradients of the two systems ...

Plasma, urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR-based metabolic profiles

Background Ankylosing spondylitis (AS) is an autoimmune rheumatic disease mostly affecting the axial skeleton. Currently, anti-tumour necrosis factor α (anti-TNF-α) represents an effective treatment for AS that may delay the progression of the disease and alleviate the symptoms if the diagnosis can be made early. Unfortunately, effective diagnostic biomarkers for AS are still ...

Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease

Introduction Kawasaki disease (KD), an acute febrile disease, characterized by systemic vasculitis, predominantly affects infants and children under 5 years of age. Coronary artery lesions (CALs) are its most critical complication, and the etiology remains unknown yet. In order to explore the value of resistin, S100A12 and soluble receptor for advanced glycation end products ...

Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China

Corresponding author: Hong-Wei Wang 0 Chinese Center for Disease Control and Prevention , 27 Nan Wei Road, Beijing 100050 , China 1 Department of Pediatrics, Tongji Hospital, Tongji Medical College

Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss

, Takayuki Hayami, Jean Chen, Wei Wang and Sunil Kapila Corresponding author: Sunil Kapila 0 0 0 Department of Orthodontics and Pediatric Dentistry, University of Michigan , 1011 North University Avenue, Ann

Navigational strategy used to intercept fly balls under real-world conditions with moving visual background fields

This study explored the navigational strategy used to intercept fly balls in a real-world environment under conditions with moving visual background fields. Fielders ran across a gymnasium attempting to catch fly balls that varied in distance and direction. During each trial, the launched balls traveled in front of a moving background texture that was projected onto an entire wall ...

Roles of quaternary structure and cysteine residues in the activity of human serine racemase

Background D-serine is an important coagonist at the NR1 subunit of the NMDA receptor class of glutamate receptors. It is chiefly synthesized in the CNS by serine racemase (SR). Regulation of SR activity is still poorly understood. As step toward developing reagents and methods for investigating SR in vitro, we analyzed structure-function relationships of a recombinant enzyme of ...

Sparse regression models for unraveling group and individual associations in eQTL mapping

Background As a promising tool for dissecting the genetic basis of common diseases, expression quantitative trait loci (eQTL) study has attracted increasing research interest. Traditional eQTL methods focus on testing the associations between individual single-nucleotide polymorphisms (SNPs) and gene expression traits. A major drawback of this approach is that it cannot model the ...

Fast and robust group-wise eQTL mapping using sparse graphical models

Background Genome-wide expression quantitative trait loci (eQTL) studies have emerged as a powerful tool to understand the genetic basis of gene expression and complex traits. The traditional eQTL methods focus on testing the associations between individual single-nucleotide polymorphisms (SNPs) and gene expression traits. A major drawback of this approach is that it cannot model ...

Identification of single-stranded and double-stranded dna binding proteins based on protein structure

Wei Wang 0 Juan Liu 0 Xionghui Zhou 0 0 School of Computer, Wuhan University , Wuhan, Hubei 430072 , People's Republic of China Background: Protein-DNA interactions are essential for many

A local average distance descriptor for flexible protein structure comparison

Hsin-Wei Wang 0 Chia-Han Chu Wen-Ching Wang Tun-Wen Pai 0 0 Department of Computer Science and Engineering, National Taiwan Ocean University , Keelung , Taiwan Background: Protein structures are

Protein-ligand binding region prediction (PLB-SAVE) based on geometric features and CUDA acceleration

Background Protein-ligand interactions are key processes in triggering and controlling biological functions within cells. Prediction of protein binding regions on the protein surface assists in understanding the mechanisms and principles of molecular recognition. In silico geometrical shape analysis plays a primary step in analyzing the spatial characteristics of protein binding ...

Ensemble classifier based on context specific miRNA regulation modules: a new method for cancer outcome prediction

Background Many calssifiers which are constructed with chosen gene markers have been proposed to forecast the prognosis of patients who suffer from breast cancer. However, few of them has been applied in clinical practice because of the bad generalization, which results from the situation that markers selected by one method are very different from those obtained by anohter mothod, ...

Fast automatic quantitative cell replication with fluorescent live cell imaging

Background live cell imaging is a useful tool to monitor cellular activities in living systems. It is often necessary in cancer research or experimental research to quantify the dividing capabilities of cells or the cell proliferation level when investigating manipulations of the cells or their environment. Manual quantification of fluorescence microscopic image is difficult ...