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4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression

Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated from the mycelium of A. cinnamomea. However, whether 4AAQB exhibits anti-inflammatory effect is not clear. The anti-inflammatory activity of 4AAQB was examined by ELISA to...

4-Acetylantroquinonol B inhibits lipopolysaccharide-induced cytokine release and alleviates sepsis through of MAPK and NFκB suppression

Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated from the mycelium of A. cinnamomea. However, whether 4AAQB exhibits anti-inflammatory effect is not clear. The anti-inflammatory activity of 4AAQB was examined by ELISA to...

A High Speed Detection Platform Based on Surface-Enhanced Raman Scattering for Monitoring Antibiotic-Induced Chemical Changes in Bacteria Cell Wall

Rapid and accurate diagnosis for pathogens and their antibiotic susceptibility is critical for controlling bacterial infections. Conventional methods for determining bacterium's sensitivity to antibiotic depend mostly on measuring the change of microbial proliferation in response to the drug. Such “biological assay” inevitably takes time, ranging from days for fast-growing...

A Location-Allocation Model for Seaport-Dry Port System Optimization

Seaports participate in hinterland economic development through partnerships with dry ports, and the combined seaport-dry port network serves as the backbone of regional logistics. This paper constructs a location-allocation model for the regional seaport-dry port network optimization problem and develops a greedy algorithm and a genetic algorithm to obtain its solution. This...

A Location-Allocation Model for Seaport-Dry Port System Optimization

Seaports participate in hinterland economic development through partnerships with dry ports, and the combined seaport-dry port network serves as the backbone of regional logistics. This paper constructs a location-allocation model for the regional seaport-dry port network optimization problem and develops a greedy algorithm and a genetic algorithm to obtain its solution. This...

A Location-Allocation Model for Seaport-Dry Port System Optimization

Seaports participate in hinterland economic development through partnerships with dry ports, and the combined seaport-dry port network serves as the backbone of regional logistics. This paper constructs a location-allocation model for the regional seaport-dry port network optimization problem and develops a greedy algorithm and a genetic algorithm to obtain its solution. This...

A Location-Allocation Model for Seaport-Dry Port System Optimization

Seaports participate in hinterland economic development through partnerships with dry ports, and the combined seaport-dry port network serves as the backbone of regional logistics. This paper constructs a location-allocation model for the regional seaport-dry port network optimization problem and develops a greedy algorithm and a genetic algorithm to obtain its solution. This...

A Potential Risk of Overestimating Apparent Diffusion Coefficient in Parotid Glands

Objectives To investigate transient signal loss on diffusion weighted images (DWI) and overestimation of apparent diffusion coefficient (ADC) in parotid glands using single shot echoplanar DWI (EPDWI). Materials and Methods This study enrolled 6 healthy subjects and 7 patients receiving radiotherapy. All participants received dynamic EPDWI with a total of 8 repetitions. Imaging...

A Retrospective Review of the Prognostic Value of ALDH-1, Bmi-1 and Nanog Stem Cell Markers in Esophageal Squamous Cell Carcinoma

Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. Immunohistochemistry...

A Single Nucleotide in Stem Loop II of 5′-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice

Background Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored. Principal Findings In this report, we investigated increased virulence of unadapted EV71 clinical isolate 237 as compared with isolate 4643 in mice. A fragment 12 nucleotides in length in stem loop...

A comparison of dose distributions in gross tumor volume between boron neutron capture therapy alone and combined boron neutron capture therapy plus intensity modulation radiation therapy for head and neck cancer

National Tsing-Hua University. Author Contributions Conceptualization: Keh-Shih Chuang, Yen-Wan Hsueh Liu, Yi-Chiao Teng, Ling-Wei Wang. Data curation: Jia-Cheng Lee, Tzung-Yi Lin, Yi-Chiao Teng. Formal ... analysis: Jia-Cheng Lee, Yen-Wan Hsueh Liu, Ling-Wei Wang. Funding acquisition: Jia-Cheng Lee. Investigation: Jia-Cheng Lee, Keh-Shih Chuang, Yen-Wan Hsueh Liu, Tzung-Yi Lin, Yi Chiao Teng, Ling-Wei Wang

A local average distance descriptor for flexible protein structure comparison

Hsin-Wei Wang 0 Chia-Han Chu Wen-Ching Wang Tun-Wen Pai 0 0 Department of Computer Science and Engineering, National Taiwan Ocean University , Keelung , Taiwan Background: Protein structures are

A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis

To identify microRNAs that are important in regulating breast cancer progression, the present study used data for the 199 961 single-nucleotide polymorphisms (SNPs) in 837 breast cancer patients genotyped in a recent genome-wide association study to identify loci associated with lymph node metastasis (LNM). SNPs tagging the 15q22.2 locus showed a significant association with LNM...

A novel regulatory event-based gene set analysis method for exploring global functional changes in heterogeneous genomic data sets

Background Analyzing gene expression data by assessing the significance of pre-defined gene sets, rather than individual genes, has become a main approach in microarray data analysis and this has promisingly derive new biological interpretations of microarray data. However, the detection power of conventional gene list or gene set-based approaches is limited on highly...

A real-time camera-based adaptive breathing monitoring system

Breathing is one of the vital signs used to assess the physical health of a subject. Non-contact-based measurements of both breathing rate and changes in breathing rate help monitor health condition of subjects more flexibly. In this paper, we present an improved real-time camera-based adaptive breathing monitoring system, which includes real time (1) adaptive breathing motion...

Age Structures and Air Pollution: What Role Does Gender Play?

We investigate the influence of age structure and gender on air pollution, dividing the age structure into four groups and use CO2 emissions as a measure of air pollution, which can be separated into four categories to ob-tain more complete findings, then employing panel cointegration techniques and panel-based error correction models. The data are collected from 29 OECD and 40...

An Open-Chip for Three-Dimensional Rotation and Translation of Particle Based on Dielectrophoresis

This study developed a three-dimensional device which can manipulate a small specimen in translation and rotation in a three-dimensional space. The device is based on an open-chip device without packaging; thus, the tip of a scanning microscope. This translational, rotational, and overturning device enables optical or scanning probe microscopy to realize the three-dimensional...

ArrayFusion: a web application for multi-dimensional analysis of CGH, SNP and microarray data

Summary: ArrayFusion annotates conventional CGH results and various types of microarray data from a range of platforms (cDNA, expression, exon, SNP, array-CGH and ChIP-on-chip) and converts them into standard formats which can be visualized in genome browsers (Affymetrix™ Integrated Genome Browser and GBrowse in the HapMap Project). Converted files can then be imported...

Association between complicated liver cirrhosis and the risk of hepatocellular carcinoma in Taiwan

Chuah. Project administration: Chih-Ming Liang, Ming-Kun Ku, Pin-I Hsu. Resources: Kai-Lung Tsai, Ming-Kun Ku, Jiunn-Wei Wang, Pin-I Hsu, Seng-Kee Chuah. Software: Kai-Lung Tsai, Ming-Kun Ku, Jiunn-Wei ... Wang, Shih-Cheng Yang. Supervision: Deng-Chyang Wu, Seng-Kee Chuah. Validation: Jiunn-Wei Wang. Visualization: Jiunn-Wei Wang, Shih-Cheng Yang. Writing ± original draft: Tsung-Hsing Hung. Writing

Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring

the statistical support of the Clinical Data Center, Office of Data Science, Taipei Medical University, Taiwan. Author Contributions Conceptualization: Cheng-Wei Wang, Tzu-Hao Chang, Sung-Hui Tseng ... . Formal analysis: Nai-Chen Chuang. Methodology: Nai-Chen Chuang. Writing – original draft: Cheng-Wei Wang, Tzu-Hao Chang, Nai-Chen Chuang, Heng-Kien Au, Chi-Huang Chen, Sung-Hui Tseng. Writing – review