Clusters, a novel hierarchical material structure that emerges from atoms or molecules, possess unique reactivity and catalytic properties, crucial in catalysis, biomedicine, and optoelectronics. Predicting cluster energy provides insights into electronic structure, magnetism, and stability. However, the structure of clusters and their potential energy surface is exceptionally...
Adenine base editors (ABEs) and cytosine base editors (CBEs) enable the single nucleotide editing of targeted DNA sites avoiding generation of double strand breaks, however, the genomic features that influence the outcomes of base editing in vivo still remain to be characterized. High-throughput datasets from lentiviral integrated libraries were used to investigate the sequence...
The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the detailed function of A3B in RS is not fully determined and it is not known whether the...
analysis: Xueqi Wang. Funding acquisition: Shiwen Wang, Mifang Liang. Investigation: Tao Huang, Wei Wu, Aqian Li, Qin Wang. Methodology: Tiezhu Liu, Jiajia Li, Xueqi Wang, Xiaoxia Huang. Resources: Chuan
Self-piercing riveting (SPR) has been widely used in automobile body jointing. However, the riveting process is prone to various forming quality failures, such as empty riveting, repeated riveting, substrate cracking, and other riveting defects. This paper combines deep learning algorithms to achieve non-contact monitoring of SPR forming quality. And a lightweight convolutional...
: Kelly Chinh, Shelley A. Johns, Patrick V. Stutz, John H. McGrew, Catherine E. Mosher. 12 / 16 Data curation: Kelly Chinh, Patrick V. Stutz. Formal analysis: Kelly Chinh, Wei Wu. Funding acquisition ... : Shelley A. Johns, Catherine E. Mosher. Investigation: Kelly Chinh, Shelley A. Johns, Catherine E. Mosher. Methodology: Kelly Chinh, Wei Wu, Catherine E. Mosher. Project administration: Kelly Chinh
Xq22.1–q22.3 deletion is a rare chromosome aberration. The purpose of this study was to identify the correlation between the phenotype and genotype of chromosome Xq22.1–q22.3 deletions. Chromosome aberrations were identified by copy number variation sequencing (CNV-seq) technology and karyotype analysis. Furthermore, we reviewed patients with Xq22.1–q22.3 deletions or a deletion...
Dong, Wei Wu, Ke Huang, Xiao-Yan Zhou. Formal analysis: Zhu Yu, Wei Wu, Ke Huang, Xiao-Yan Zhou, Meng Wang. Funding acquisition: Guanping Dong, Xiao-Yan Zhou, Meng Wang, Junfen Fu. 9 / 12 Investigation ... : Wei Wu, Ke Huang, Xiao-Yan Zhou, Hao Wang. Methodology: Guanping Dong, Wei Wu, Xiao-Yan Zhou, Hao Wang. Project administration: Guanping Dong, Hao Wang, Meng Wang. Resources: Wei Wu, Meng Wang
Regulation of messenger RNA stability is pivotal for programmed gene expression in bacteria and is achieved by a myriad of molecular mechanisms. By bulk sequencing of 5′ monophosphorylated mRNA decay intermediates (5′P), we show that cotranslational mRNA degradation is conserved among both Gram-positive and -negative bacteria. We demonstrate that, in species with 5′–3...
al. (DOCX) Author Contributions Conceptualization: Tzu-Rong Peng, Fang-Pei Tsai, Ta-Wei Wu. Data curation: Tzu-Rong Peng, Fang-Pei Tsai. Formal analysis: Tzu-Rong Peng, Ta-Wei Wu. Software: Tzu ... -Rong Peng. Writing – original draft: Tzu-Rong Peng, Fang-Pei Tsai. Writing – review & editing: Ta-Wei Wu. 13 / 18 9. An W, Li S, Qin L. Role of honey in preventing radiation-induced oral mucositis: a
Argyriou, Giorgos Bakoyannis, Wei Wu. Project administration: Mary Jo Rattermann. Resources: Mary Jo Rattermann, Melissa A. Cyders. Software: Evangelia Argyriou, Giorgos Bakoyannis. Supervision: Melissa ... A. Cyders. Writing – original draft: Evangelia Argyriou. Writing – review & editing: Evangelia Argyriou, Wei Wu, Mary Jo Rattermann, Melissa A. Cyders. 11 / 13 12 / 13 1. Cunningham JA
. Data curation: Chou-Chin Lan, Po-Chun Hsieh, I-Shiang Tzeng, Yao-Kuang Wu. Formal analysis: Po-Chun Hsieh, I-Shiang Tzeng, Mei-Chen Yang, Chih-Wei Wu, Wen-Lin Su, Yao-Kuang Wu. Funding acquisition ... : Chou-Chin Lan. Methodology: Mei-Chen Yang, Chih-Wei Wu, Wen-Lin Su. Supervision: Chou-Chin Lan. Writing – original draft: Chou-Chin Lan, Yao-Kuang Wu. Writing – review & editing: Chou-Chin Lan, Yao
Four Fanconi anemia (FA) genes (BRCA1, BRCA2, PALB2 and RAD51C) are defined as breast cancer (BC) susceptibility genes. Other FA genes have been inconsistently associated with BC. Thus, the role of other FA genes in BC should be explored in specific populations. Mutations in 16 FA genes were screened with a 98-gene panel sequencing assay in a cohort of 1481 Chinese patients with...
Colorectal cancer (CRC) is a multifactorial disease with genetic and environmental factors. Regional differences in risk factors are an important reason for the different incidences of CRC in different regions. The goal was to clarify the intestinal microbial composition and structure of CRC patients in different regions and construct CRC risk prediction models based on regional...
HUAWEI-Corn-WhitePaper-50. (JPG) S1 Table. The original statistical result of the sample grains. (XLSX) Author Contributions Conceptualization: Xiaochun Zhong. Data curation: Jie Zhang, Wei Wu. Formal ... analysis: Jie Zhang, Wei Wu. Funding acquisition: Shengping Liu, Xiaochun Zhong, Tao Liu. 17 / 19 Investigation: Jie Zhang. Methodology: Jie Zhang, Tao Liu. Resources: Tao Liu. Software: Jie Zhang, Wei
In order to obtain continuous stratum information during TBM tunneling, using TBM tunneling parameters, stratum recognition is carried out through the K-nearest neighbor model, and the model is improved by the entropy weight method to improve the stratum recognition rate. By analyzing the correlation between TBM tunneling characteristic parameters and stratum, the tunneling...
Base editors have been reported to induce off-target mutations in cultured cells, mouse embryos and rice, but their long-term effects in vivo remain unknown. Here, we develop a Systematic evaluation Approach For gene Editing tools by Transgenic mIce (SAFETI), and evaluate the off-target effects of BE3, high fidelity version of CBE (YE1-BE3-FNLS) and ABE (ABE7.10F148A) in ~400...
forward to assessing this in further studies. Author Contributions Conceptualization: Li-Hsiang Chen, Li-Wei Wu. Data curation: Li-Hsiang Chen, Li-Wei Wu. Formal analysis: Li-Hsiang Chen, Li-Wei Wu ... . Investigation: Li-Hsiang Chen, Li-Wei Wu. Methodology: Li-Hsiang Chen, Li-Wei Wu. Project administration: Li-Hsiang Chen, Li-Wei Wu. Supervision: Li-Wei Wu. Validation: Li-Hsiang Chen, Li-Wei Wu. 10 / 13
How to factor both tumor burden and oncogenic genomic mutations as variables to predict the outcome of endocrine-based therapy (ET) in ER-positive/HER2-negative metastatic breast cancer patients (MBC) remains to be explored. Blood samples prospectively collected from 163 ER-positive/HER2-negative female MBC patients, before ET, were used for cell-free tumor DNA (cfDNA) analysis...
Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers. Lynch syndrome is caused by pathogenic germline variants in one of four DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2) or by an EPCAM...