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Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome

Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, ChinaHoukai Li & Weidong Zhang AuthorsSearch for Zhang Lin in:Nature Research journals • PubMed • Google Scholar Search for ... • Google Scholar Search for Houkai Li in:Nature Research journals • PubMed • Google Scholar Search for Yiping Li in:Nature Research journals • PubMed • Google Scholar Search for Weidong Zhang in:Nature

Correction to: GMR: graph-compatible MapReduce programming model

In the original publication, Fig. 12 was incorrectly presented. The plot line and legends of Fig. 12a, c, e and f should not overlap. The original article was corrected.

Identification and characterization of two linear epitope motifs in hepatitis E virus ORF2 protein

Contributions Conceptualization: Heng Wang, Guihong Zhang. Formal analysis: Meng Zeng, Ruyue Song. Investigation: Weidong Zhang, Honglang Gu, Wanli Chen. Project administration: Heng Wang, Guihong Zhang ... . Resources: Meng Zeng, Chihai Ji. Supervision: Guihong Zhang. Validation: Weidong Zhang, Honglang Gu, Wanli Chen. Writing ± original draft: Heng Wang. Writing ± review & editing: Guihong Zhang. 13 / 15 14

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

Contributions Data curation: Weidong Zhang. Formal analysis: Weidong Zhang, Guangju Zhai. Funding acquisition: Guangju Zhai. Investigation: Weidong Zhang, Guangju Zhai. Resources: Guangju Zhai. Supervision ... : Guangju Zhai. Validation: Edward W. Randell, Guang Sun, Guangju Zhai. Writing ± original draft: Weidong Zhang. Writing ± review & editing: Edward W. Randell, Guang Sun, Sergei Likhodii, Ming Liu, Andrew

An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities

In a continuing effort to discover more anti-inflammatory medicinal plants in China, the anti-inflammatory activities of 101 extracts from different parts of 84 traditional medicinal plants were evaluated by a panel of in vitro and in vivo assays. Nuclear factor-kappa B (NF-κB) inhibitory effects were determined by luciferase assay in stably transfected Hela cells. Cytotoxic...

The Neural Responses to Social Cooperation in Gain and Loss Context

Cooperation is pervasive and constitutes the core behavioral principle of human social life. Previous studies have revealed that mutual cooperation was reliably correlated with two reward-related brain regions, the ventral striatum and the orbitofrontal cortex. Using functional magnetic resonance imaging (fMRI), this study sought to investigate how the loss and gain contexts...

The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs

• PubMed • Google Scholar Search for Xuan Li in:Nature Research journals • PubMed • Google Scholar Search for Weidong Zhang in:Nature Research journals • PubMed • Google Scholar Contributions C.L ... declare that they have no competing interests. Corresponding authors Correspondence to Honglin Li or Xuan Li or Weidong Zhang. Electronic supplementary material Dataset 1Dataset 2 Rights and

Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons

Schistosomiasis is a neglected parasitic disease of major public health concern as it affects over 250 million people in developing countries. Currently there is no licensed vaccine available against schistosomiasis. The Schistosoma mansoni calpain protein, Sm-p80, is a leading vaccine candidate now ready to move to clinical trials. In order to better assess Sm-p80 vaccine...

Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

Background Metabolic abnormalities are more associated with central obesity than peripheral obesity, but the underlying mechanisms are largely unknown. The present study was to identify serum metabolic biomarkers which distinguish metabolically unhealthy centrally obese (MUCO) from metabolically healthy peripherally obese (MHPO) individuals. Methods A two-stage case–control study...

Addition of External Organic Carbon and Native Soil Organic Carbon Decomposition: A Meta-Analysis

Background Extensive studies have been conducted to evaluate the effect of external organic Carbon on native soil organic carbon (SOC) decomposition. However, the direction and extent of this effect reported by different authors is inconsistent. Objective The objective was to provide a synthesis of existing data that comprehensively and quantitatively evaluates how the soil...

Time Series Analysis of Hand-Foot-Mouth Disease Hospitalization in Zhengzhou: Establishment of Forecasting Models Using Climate Variables as Predictors

Background Large-scale outbreaks of hand-foot-mouth disease (HFMD) have occurred frequently and caused neurological sequelae in mainland China since 2008. Prediction of the activity of HFMD epidemics a few weeks ahead is useful in taking preventive measures for efficient HFMD control. Methods Samples obtained from children hospitalized with HFMD in Zhengzhou, Henan, China, were...

The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia

Hyperuricemia (HU) often progresses to combine with non-alcoholic fatty liver disease (NAFLD) in the clinical scenario, which further exacerbates metabolic disorders; early detection of biomarkers, if obtained during the HU progression, may be beneficial for preventing its combination with NAFLD. This study aimed to decipher the biomarkers and mechanisms of the development of...

Comparative Efficacy and Safety of Deferoxamine, Deferiprone and Deferasirox on Severe Thalassemia: A Meta-Analysis of 16 Randomized Controlled Trials

collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have the following interests. Weidong Zhang is employed by Novartis Pharmaceuticals Oncology

Systematic Analysis of the Multiple Bioactivities of Green Tea through a Network Pharmacology Approach

During the past decades, a number of studies have demonstrated multiple beneficial health effects of green tea. Polyphenolics are the most biologically active components of green tea. Many targets can be targeted or affected by polyphenolics. In this study, we excavated all of the targets of green tea polyphenolics (GTPs) though literature mining and target calculation and...

Role of a Genetic Variant on the 15q25.1 Lung Cancer Susceptibility Locus in Smoking-Associated Nasopharyngeal Carcinoma

Background The 15q25.1 lung cancer susceptibility locus, containing CHRNA5, could modify lung cancer susceptibility and multiple smoking related phenotypes. However, no studies have investigated the association between CHRNA5 rs3841324, which has been proven to have the highest association with CHRNA5 mRNA expression, and the risk of other smoking-associated cancers, except lung...

Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins

Background Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research showed that extracts of H. japonicum can induce apoptosis in leukaemia cells. We also previously systematically analysed and isolated the chemical composition...

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway

Astragaloside IV (AGS-IV) is a main active ingredient of Astragalus membranaceus Bunge, a medicinal herb prescribed as an immunostimulant, hepatoprotective, antiperspirant, a diuretic or a tonic as documented in Chinese Materia Medica. In the present study, we employed a high-throughput comparative proteomic approach based on 2D-nano-LC-MS/MS to investigate the possible mechanism...

Protective Effects of Huang-Lian-Jie-Du-Tang against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Rats

Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional formula that has long been used for treatment of inflammatory diseases in Traditional Chinese Medicine. In this study, we examined its protective effect against sepsis in an experimental septic model induced by cecal ligation and puncture (CLP) in rats. The results demonstrated that prophylactic administration of HLJDT protected...

Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective

Zhang,4 and Jing Zhao1,4 1Department of Mathematics, Logistical Engineering University, Chongqing 401311, China 2Tibet Traditional Medical College, Lhasa 850000, China 3The National Medical College