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Search: authors:"Weihong Gu"

3 papers found.
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Interrogating the “unsequenceable” genomic trinucleotide repeat disorders by long-read sequencing

Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a number of genetic diseases. Sanger sequencing and next-generation short-read sequencing are unable to interrogate TRE reliably. We developed a novel algorithm called RepeatHMM to estimate repeat counts from long-read sequencing data. Evaluation on simulation data, real amplicon sequencing ...

Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation

PhD, major in bioinorganic chemistry, Institute of High Energy Physics, Chinese Academy of Sciences; Weihong Gu(co-author): Candidate of PhD, major in bioinorganic chemistry, Institute of High Energy

Utilizing Gold Nanoparticle Probes to Visually Detect DNA Methylation

The surface plasmon resonance (SPR) effect endows gold nanoparticles (GNPs) with the ability to visualize biomolecules. In the present study, we designed and constructed a GNP probe to allow the semi-quantitative analysis of methylated tumor suppressor genes in cultured cells. To construct the probe, the GNP surfaces were coated with single-stranded DNA (ssDNA) by forming Au–S ...