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Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

English-language editing. Author Contributions Conceptualization: Bo Zhai, Jun Xu. Data curation: Weihua Sun, Hao Cheng. Formal analysis: Jiejie Dong, Jun Xu. Funding acquisition: Bo Zhai, Fengli Hu ... , Jun Xu. Investigation: Jiejie Dong, Bo Zhai, Weihua Sun, Fengli Hu, Hao Cheng. Methodology: Jiejie Dong, Weihua Sun. 13 / 16 Project administration: Jiejie Dong, Bo Zhai, Weihua Sun, Jun Xu. Resources

Inactivation of the Progesterone Receptor in Mx1+ Cells Potentiates Osteogenesis in Calvaria but Not in Long Bone

The effect of progesterone on bone remains elusive. We previously reported that global progesterone receptor (PR) knockout mice displayed high bone mass phenotype, suggesting that PR influences bone growth and modeling. Recently, Mx1+ cells were characterized to be mesenchymal stem cell-like pluripotent Cells. The aim of this study was to evaluate whether the PR in Mx1+ cells...

CRTC2 enhances HBV transcription and replication by inducing PGC1α expression

Background Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes. Based on the HBV enhancer and promoter complex that links hepatic glucose metabolism to its transcription and replication, HBV adopts a regulatory system that is unique to the hepatic gluconeogenic genes. CRTC2, the CREB-regulated transcription coactivator 2, is a critical...