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AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and ...

Financial burden of healthcare for cancer patients with social medical insurance: a multi-centered study in urban China

Cancer accounts for one-fifth of the total deaths in China and brings heavy financial burden to patients and their families. Chinese government has made strong commitment to develop three types of social medical insurance since 1997 and recently, more attempts were invested to provide better financial protection. To analyze health services utilization and financial burden of ...

A mesh-free algorithm for ROF model

The total variation (TV) denoising method is a PDE-based technique that preserves the edges well but has undesirable staircase effect in some cases, namely, the translation of smooth regions (ramps) into piecewise constant regions (stairs). This paper introduces a novel mesh-free approach using TV (ROF model) regularization and radial basis function (RBF) for the numerical ...

Correction of hyperopia with astigmatism following radial keratotomy with daily disposable plus spherical contact lens: a case report

Purpose To report the refractive correction in a case of hyperopia and astigmatism following radial keratotomy. Methods A case report. Results A 47-year-old woman, who had undergone refractive surgery for radial keratotomy in both eyes 22 years before the present study, presented to our clinic with blurred vision. Her best corrected visual acuity, with spectacle correction of +3.50 ...

Lipid lowering therapy in patients with atherosclerotic cardiovascular diseases: Which matters in the real world? Statin intensity or low-density lipoprotein cholesterol level? ‒ Data from a multicenter registry cohort study in Taiwan

multicenter registry cohort study in Taiwan Yen-Ting Yeh 0 Wei-Hsian Yin Wei-Kung Tseng Fang-Ju Lin Hung-I Yeh Jaw- Wen Chen Yen-Wen Wu 0 Chau-Chung Wu on behalf of the Taiwanese Katriina Aalto-Setala ... Medicine, Tainan Municipal Hospital, Tainan, Taiwan), Wen-Harn Pan (Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan), Hung-I Yeh, Chau-Chung Wu, and Jaw-Wen Chen. The lead author of T

Survival and medical utilization of children and adolescents with prolonged ventilator-dependent and associated factors

Over the course of a year, more than 20,000 patients in Taiwan require prolonged mechanical ventilation (PMV). Data from the National Health Insurance Research Database for patients between 2005 and 2011 were used to conduct a retrospective analysis on ventilator dependence. The study subjects were PMV patients aged <17 years in Taiwan. A multiple regression model employing general ...

Is there a relationship between geographic distance and uptake of HIV testing services? A representative population-based study of Chinese adults in Guangzhou, China

Conceptualization: Wen Chen, Brian J. Hall, Joseph D. Tucker, Carl Latkin, Li Ling. Data curation: Wen Chen, Brian J. Hall. Formal analysis: Wen Chen, Fangjing Zhou. Funding acquisition: Wen Chen, Brian J. Hall ... , Joseph D. Tucker. Investigation: Wen Chen, Fangjing Zhou. Methodology: Wen Chen, Fangjing Zhou. Project administration: Wen Chen, Fangjing Zhou, Brian J. Hall. Resources: Wen Chen. Software: Wen Chen

Plasma kallistatin in critically ill patients with severe sepsis and septic shock

Kallistatin, an endogenous serine proteinase inhibitor, is protective against sepsis in animal models. The aim of this study was to determine the plasma concentration of kallistatin in intensive care unit (ICU) patients with severe sepsis and septic shock and to determine their potential correlation with disease severity and outcomes. We enrolled 86 ICU patients with severe sepsis ...

Comparison of Primary Care Experiences in Village Clinics with Different Ownership Models in Guangdong Province, China

Objectives In order to improve the quality of services at village clinics (VCs), which are important primary care service providers in rural China, the Chinese government has encouraged the township hospitals to own and manage VCs. There are currently three models of ownership and management of VCs: township hospital-owned and -managed (HVC), village committee-owned and -managed ...

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

Objectives We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients. Materials and methods A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Secondary data were ...

Incidence, risk, and associated factors of depression in adults with physical and sensory disabilities: A nationwide population-based study

Background Physical disability has been associated with the risk of depression. We examined the incidence, risk, and associated factors of depression in Taiwanese adults with physical/sensory disabilities. Methods Two national databases were used to retrospectively analyze 749,491 ≥20-year-old Taiwanese with physical/sensory disabilities in 2002–2008. The incidence of depression ...

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?

Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In ...

Effect of endurance exercise on microRNAs in myositis skeletal muscle—A randomized controlled study

. Boehler, Marshall W. Hogarth, Matthew D. Barberio, Svetlana Ghimbovschi, Kristy J. Brown, Yi-Wen Chen, Heather Gordish-Dressman. Funding acquisition: Ingrid E. Lundberg, Kanneboyina Nagaraju

Productivity spillovers of organization capital

Investments in organization capital increase productivity of not just the investing firm but could also spillover to other firms—similar to investments in research and development. Recent evidence at the industry and economy level suggests such spillovers could be important. In this paper, we fail to find evidence of knowledge spillovers from organization capital that increase the ...

The effect of a well-resolved stratosphere on East Asian winter climate

This study performs a comparison between models with and without well-resolved stratosphere on the simulation of the East Asian winter climate. The results reveal that the Fifth Coupled Model Inter-comparison Project (CMIP5) models with model top above the stratopause have a better simulation of the distribution of surface air temperature, sea level pressure and precipitation than ...

Energy state affects exploratory behavior of tree sparrows in a group context under differential food-patch distributions

Background When facing a novel situation, animals can retreat or leave to avoid risks, but will miss potential resources and opportunities. Alternatively they may reduce environmental uncertainty by exploration, while risking no energy rewards and exposure to hazards, and use the information retrieved for subsequent decision making. When exploring, however, animals may adopt ...

Asymmetry of the winter extra-tropical teleconnections in the Northern Hemisphere associated with two types of ENSO

Asymmetric atmospheric responses to ENSO are revisited after dividing it into two types: eastern-Pacific (EP) and central-Pacific (CP) ENSO. The EP ENSO triggers two obvious asymmetric atmospheric teleconnections: One is the Pacific–North American-like teleconnection. Its asymmetry is characterized by weaker amplitudes during the EP La Niña than EP El Niño, which is caused by a ...