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388 papers found.
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Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

/ 11 Author Contributions Conceptualization: Yu-hua Huang, Yi-Chun Chen. Data curation: Chiung-Mei Chen, Kuo-Hsuan Chang, Huei-Wen Chen. Formal analysis: Yu-hua Huang, Huei-Wen Chen. Methodology

Pre-existing malignancy results in increased prevalence of distinct populations of CD4+ T cells during sepsis

, Jennifer M. Robertson, Mandy L. Ford. Funding acquisition: Craig M. Coopersmith, Mandy L. Ford. Investigation: Jianfeng Xie, Ching-wen Chen, Wenxiao Zhang. Project administration: Craig M. Coopersmith ... , Ching-wen Chen, Wenxiao Zhang, Craig M. Coopersmith. 17 / 20 18 / 20 Natl Acad Sci U S A. 2009; 106(15):6303±8. https://doi.org/10.1073/pnas.0809422106 PMID: 19332785; PubMed Central PMCID: PMC2669369

Prognostic factors of noninvasive mechanical ventilation in lung cancer patients with acute respiratory failure

: Wei-Chih Chen, Wen-Kuang Yu, Yen-Wen Chen, Kuang-Yao Yang. Project administration: Wei-Chih Chen. Supervision: Kuang-Yao Yang. Validation: Wei-Chih Chen, Wen-Kuang Yu, Yen-Wen Chen, Kuang-Yao Yang ... . Visualization: Wei-Chih Chen, Wen-Kuang Yu, Yen-Wen Chen, Kuang-Yao Yang. Writing ± original draft: Wei-Chih Chen, Vincent Yi-Fong Su. Writing ± review & editing: Wei-Chih Chen, Kuang-Yao Yang. 9 / 11 10 / 11 1

Financial burden of healthcare for cancer patients with social medical insurance: a multi-centered study in urban China

Cancer accounts for one-fifth of the total deaths in China and brings heavy financial burden to patients and their families. Chinese government has made strong commitment to develop three types of social medical insurance since 1997 and recently, more attempts were invested to provide better financial protection. To analyze health services utilization and financial burden of...

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and...

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and...

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and...

AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways

The tyrosine kinase Src is involved in the progression of many cancers. Moreover, inhibiting Src activity has been shown to obstruct several signaling pathways regulated by the EGFR. Thus, Src is a valuable target molecule in drug development. The purpose of this study was to identify compounds that directly or indirectly modulate Src to suppress lung cancer cell growth and...

Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2). F0 rats were fed with a standard chow (SC) or HF diet for 8 weeks before mating, up to termination of lactation for their first-generation of offspring (F1-SC and F1-HF). F1...

A mesh-free algorithm for ROF model

The total variation (TV) denoising method is a PDE-based technique that preserves the edges well but has undesirable staircase effect in some cases, namely, the translation of smooth regions (ramps) into piecewise constant regions (stairs). This paper introduces a novel mesh-free approach using TV (ROF model) regularization and radial basis function (RBF) for the numerical...

Cellular hnRNP A2/B1 interacts with the NP of influenza A virus and impacts viral replication

. Investigation: Cheng-Kai Chang, Chi-Jene Chen, Chih-Ching Wu, Shiau-Wen Chen, Rei-Lin Kuo. Methodology: Cheng-Kai Chang, Chi-Jene Chen, Chih-Ching Wu. Project administration: Shin-Ru Shih. Supervision: Shin

Correction of hyperopia with astigmatism following radial keratotomy with daily disposable plus spherical contact lens: a case report

Purpose To report the refractive correction in a case of hyperopia and astigmatism following radial keratotomy. Methods A case report. Results A 47-year-old woman, who had undergone refractive surgery for radial keratotomy in both eyes 22 years before the present study, presented to our clinic with blurred vision. Her best corrected visual acuity, with spectacle correction of +3...

CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis

. Coopersmith, Mandy L. Ford. Investigation: Kimberly M. Ramonell, Wenxiao Zhang, Annette Hadley, Ching-wen Chen, Katherine T. Fay, John D. Lyons, Nathan J. Klingensmith. Methodology: Kevin W. McConnell, Craig

Survival and medical utilization of children and adolescents with prolonged ventilator-dependent and associated factors

Over the course of a year, more than 20,000 patients in Taiwan require prolonged mechanical ventilation (PMV). Data from the National Health Insurance Research Database for patients between 2005 and 2011 were used to conduct a retrospective analysis on ventilator dependence. The study subjects were PMV patients aged <17 years in Taiwan. A multiple regression model employing...

Productivity spillovers of organization capital

Investments in organization capital increase productivity of not just the investing firm but could also spillover to other firms—similar to investments in research and development. Recent evidence at the industry and economy level suggests such spillovers could be important. In this paper, we fail to find evidence of knowledge spillovers from organization capital that increase...

Plasma kallistatin in critically ill patients with severe sepsis and septic shock

Kallistatin, an endogenous serine proteinase inhibitor, is protective against sepsis in animal models. The aim of this study was to determine the plasma concentration of kallistatin in intensive care unit (ICU) patients with severe sepsis and septic shock and to determine their potential correlation with disease severity and outcomes. We enrolled 86 ICU patients with severe...

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?

Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In...

Comparison of Primary Care Experiences in Village Clinics with Different Ownership Models in Guangdong Province, China

Objectives In order to improve the quality of services at village clinics (VCs), which are important primary care service providers in rural China, the Chinese government has encouraged the township hospitals to own and manage VCs. There are currently three models of ownership and management of VCs: township hospital-owned and -managed (HVC), village committee-owned and -managed...