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206 papers found.
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Autophagy is required for human umbilical cord mesenchymal stem cells to improve spatial working memory in APP/PS1 transgenic mouse model

Background Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a variety of mechanisms. However, no studies have looked at the effects of autophagy on neuroprotective function of huMSCs in the AD mouse model. Thus, in this study ...

Robust gdf9 and bmp15 expression in the oocytes of ovotestes through the Figla-independent pathway in the hermaphroditic black porgy, Acanthopagrus schlegelii

-012-MY3) and the Ministry of Education, Taiwan. Author Contributions Conceptualization: Guan-Chung Wu, Ching-Fong Chang. Data curation: Guan-Chung Wu, Jia-Wun Luo, Hau-Wen Li. Formal analysis: Jia-Wun ... Luo, Hau-Wen Li. Funding acquisition: Guan-Chung Wu, Ching-Fong Chang. Investigation: Jia-Wun Luo. 17 / 20 Methodology: Jia-Wun Luo, Hau-Wen Li, Chen-Hsiu Huang. Project administration: Guan-Chung Wu

Alseodaphnopsis: A new genus of Lauraceae based on molecular and morphological evidence

. Rohwer, Hsi-wen Li. Project administration: Jie Li. Resources: Jian-wu Li. Software: Yue-qing Mo, Lang Li. Supervision: Jie Li. Writing ± original draft: Yue-qing Mo. Writing ± review & editing: Yue ... -qing Mo, Lang Li, Jens G. Rohwer, Hsi-wen Li, Jie Li. 13 / 14 1. Rohwer JG , Li J , Rudolph B , Schmidt SA , van der Werff H & Li HW. Is Persea (Lauraceae) monophyletic? evidence from nuclear ribosomal

Integrable open spin chains from flavored ABJM theory

We compute the two-loop anomalous dimension matrix in the scalar sector of planar \( \mathcal{N}=3 \) flavored ABJM theory. Using coordinate Bethe ansatz, we obtain the reflection matrices and confirm that the boundary Yang-Baxter equations are satisfied. This establishes the integrability of this theory in the scalar sector at the two-loop order.

Considering choline as methionine precursor, lipoproteins transporter, hepatic promoter and antioxidant agent in dairy cows

During the transition period, fatty liver syndrome may be caused in cows undergo negative energy balance, ketosis or hypocalcemia, retained placenta or mastitis problems. During the transition stage, movement of non-esterified fatty acids (NEFA) increases into blood which declines the hepatic metabolism or reproduction and consequently, lactation performance of dairy cows ...

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice

The role of chemokine receptor in age-related macular degeneration (AMD) remains elusive. The objective of this study is to investigate the role of chemokine receptor Cxcr5 in the pathogenesis of AMD. Cxcr5 gene expression levels (mRNA and protein) are higher in the retina and retinal pigment epithelium (RPE) of aged C57BL/6 wild type mice than younger ones. Vascular and glial ...

The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the molecular mechanism underlying the acidic microenvironment-induced invasion and metastasis. We examined the expression of the acid-sending ion channel (ASIC) family members after ...

miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway

Background Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to function in several carcinomas, but its role in gastric cancer (GC) is still unknown. This study aims to explore the effects of miR-324-3p on the development of GC. Methods Expression of miR-324-3p was examined in ...

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

facilitates decision-making regarding the dosage regimen in early-phase clinical studies. Animal species are often used to study the PK of a compound under Nikolaos Tsamandouras and Wen Li Kelly Chen have equal

On the Bethe states of the one-dimensional supersymmetric t − J model with generic open boundaries

By combining the algebraic Bethe ansatz and the off-diagonal Bethe ansatz, we investigate the supersymmetric t − J model with generic open boundaries. The eigenvalues of the transfer matrix are given in terms of an inhomogeneous T − Q relation, and the corresponding eigenstates are expressed in terms of nested Bethe states which have welldefined homogeneous limit. This exact ...

Ptilagrostis contracta (Stipeae, Poaceae), a New Species Endemic to Qinghai-Tibet Plateau

A new species, Ptilagrostis contracta, endemic to Qinghai-Tibet Plateau is described and illustrated. It is distinguished from other species in Ptilagrostis by having contracted panicles, 1-geniculate awns with hairy columns and scabrous bristles and evenly pubescent lemmas. Evidence from lemma epidermal pattern, cytology and molecular phylogenetic analyses based on the nuclear ITS ...

DNA barcoding evaluation and implications for phylogenetic relationships in Lauraceae from China

expert at KUN, Hsi-Wen Li, who is one of the co-authors, identified the vouchers (S1 Table) based on the reproductive or vegetative characters available. All vouchers were stored at the Herbarium of

MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling

MicroRNAs (miRs) are mRNA-regulatory molecules that fine-tune gene expression and modulate both processes of development and tumorigenesis. Our previous studies identified progranulin A (GrnA) as a growth factor which induces zebrafish hepatic outgrowth through MET signaling. We also found that miR-145 is one of potential fine-tuning regulators of GrnA involved in embryonic hepatic ...

Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo

Shp2 played an important role in cigarette-smoke-mediated inflammation, surfactant homeostasis and asthmatic airway remodeling. However, whether shp2 plays a key role in epithelium-associated allergic reaction is still unknown. In this study, LPS and OVA were observed to induce the production of IL-25 in bronchial epithelial cells in vitro via the activation of MAPK p38 and JNK. ...

Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells

Background Triple-negative breast cancer (TNBC) is the most intractable type of breast cancer, and there is a lack of effective targeted therapy. Insulin-like growth factor-1 receptor (IGF-1R) is reportedly a potential target for TNBC treatment. However, satisfying treatment outcomes in breast cancer patients have yet to be achieved with IGF-1R-targeted agents. Methods To confirm ...

mCAF: a multi-dimensional clustering algorithm for friends of social network services

networks and cloud computing. Prof. Chang is the Director of the Web Information and Data Engineering Laboratory (WIDELab). Yu‑Wen Li obtained her B.S. degrees in the Department of Computer Science and

Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan

, Tainan; Chia-Wen Li, Nan-Yao Lee, and Wen-Chien Ko, National Cheng Kung University Hospital, Tainan; Po-Liang Lu and Yen-Hsu Chen, Kaohsiung Medical University Hospital, Kaohsiung; Hsi-Hsun Lin, E-Da

Bethe ansatz solutions of the τ 2-model with arbitrary boundary fields

The quantum τ 2-model with generic site-dependent inhomogeneity and arbitrary boundary fields is studied via the off-diagonal Bethe Ansatz method. The eigenvalues of the corresponding transfer matrix are given in terms of an inhomogeneous T − Q relation, which is based on the operator product identities among the fused transfer matrices and the asymptotic behavior of the transfer ...

Motility characteristics in the transition zone in Gastroesophageal Reflux Disease (GORD) patients

Background Defects in distal oesophageal peristalsis was thought to be an indication of incomplete bolus transit (BT). However, the role of transition zone (TZ) defects in the BT in gastroesophageal reflux disease (GORD) patients needs clarification. The aim of this study was to assess the TZ defects in GORD patients and to explore the relationship between TZ defects and BT. ...

Quasi 1D modeling of two-phase flow and deposit formation for urea-selective catalytic reduction systems

A quasi 1D model of two-phase flow for a urea-selective catalytic reduction (SCR) system is developed which can calculate not only the generation of reducing agent but also the formation of deposits in the exhaust pipe. The gas phase flow is solved through Euler method, variables are stored on staggered grids, and the semi-implicit method for pressure-linked equation (SIMPLE) ...