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Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

anticancer agents Li Zhou 2 Xu Zhang 1 Wen Zhou 0 0 School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, E. 232, University Town , Waihuan Rd, Panyu, Guangzhou 510006, Guangdong

Impact of viscosity modifier on asphalt properties used for bus rapid transit lane in Chengdu

In order to find the effect of different viscosity modifier dosages on asphalt binder’s performance in bus rapid transit lanes in the city of Chengdu, three different viscosity modifiers were analyzed: TAFPACK-super (TPS), high-viscosity additive (HVA) and road-science-technology (RST), and four different asphalt binders were investigated through laboratory experiments. The ...

Exploring the potential of open big data from ticketing websites to characterize travel patterns within the Chinese high-speed rail system

Big data have contributed to deepen our understanding in regards to many human systems, particularly human mobility patterns and the structure and functioning of transportation systems. Resonating the recent call for ‘open big data,’ big data from various sources on a range of scales have become increasingly accessible to the public. However, open big data relevant to travelers ...

Zinc mediates the neuronal activity–dependent anti-apoptotic effect

. Author Contributions Funding acquisition: Rong Liu. Methodology: Ji Zeng, Xiao-chuan Wang. Project administration: Rong Liu. Supervision: Xin-wen Zhou, Rong Liu. Validation: Qun Wang. Writing

Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations-dominant corneal optics

Background The aim of the study is to raise the awareness of the influence of coma-like higher-order aberrations (HOAs) on power and orientation of refractive astigmatism (RA) and to explore how to account for that influence in the planning of topography-guided refractive surgery in eyes with coma-like-aberrations-dominant corneal optics. Methods Eleven eyes with ...

An analysis of the entrainment effect of dry debris avalanches on loose bed materials

Substrate entrainment can greatly influence the mass movement process of a debris avalanche because it can enlarge the landslide volume and change the motion characteristics of the sliding masses. To study the interaction between debris avalanches and erodible substrate, physical modeling experiments varying in the mass of granular flow and substrate thickness were performed. The ...

Event Recognition Based on Deep Learning in Chinese Texts

Event recognition is the most fundamental and critical task in event-based natural language processing systems. Existing event recognition methods based on rules and shallow neural networks have certain limitations. For example, extracting features using methods based on rules is difficult; methods based on shallow neural networks converge too quickly to a local minimum, resulting ...

Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia

Background The AZFc deletion has been associated with wide range of phenotypes including complete absence of germ cells in the testes (SCOS), reduction in germ cells hypospermatogenesis, and maturation arrest. The main objective of this study was to evaluate the relationship between AZFc microdeletions and testicular histology in South Chinese men with azoospermia or severe ...

Microstructures and properties of rapidly solidified Cu90Zr10-x Al x alloys

University of Technology , Dalian 116024, China 2. Changchun Equipment & Technology Research Institute , Changchun 130012 , China 1 , and Shu-ping Gou 2 Bing-wen Zhou 3 Xing-guo Zhang Cu90Zr10-xAlx (x=1, 3, 5

An Extended N-Player Network Game and Simulation of Four Investment Strategies on a Complex Innovation Network

As computer science and complex network theory develop, non-cooperative games and their formation and application on complex networks have been important research topics. In the inter-firm innovation network, it is a typical game behavior for firms to invest in their alliance partners. Accounting for the possibility that firms can be resource constrained, this paper analyzes a ...

Number of blastocysts biopsied as a predictive indicator to obtain at least one normal/balanced embryo following preimplantation genetic diagnosis with single nucleotide polymorphism microarray in translocation cases

Purpose The aim of this study is to investigate the minimum number of blastocysts for biopsy to increase the likelihood of obtaining at least one normal/balanced embryo in preimplantation genetic diagnosis (PGD) for translocation carriers. Methods This blinded retrospective study included 55 PGD cycles for Robertsonian translocation (RT) and 181 cycles for reciprocal translocation ...

Forecasting and prevention of water inrush during the excavation process of a diversion tunnel at the Jinping II Hydropower Station, China

Introduction Estimating groundwater inflow into a tunnel before and during the excavation process is an important task to ensure the safety and schedule during the underground construction process. Case description Here we report a case of the forecasting and prevention of water inrush at the Jinping II Hydropower Station diversion tunnel groups during the excavation process. The ...

Probiotic properties of lactic acid bacteria isolated from traditionally fermented Xinjiang cheese

Ramila AZAT, Yan LIU, Wei LI, Abdurihim KAYIR, Ding-bo LIN, Wen-wen ZHOU, and Xiao-dong ZHENG declare that they have no conflict of interest. This article does not contain any studies with human or animal

Comparison of Corneal Epithelial and Stromal Thickness Distributions between Eyes with Keratoconus and Healthy Eyes with Corneal Astigmatism ≥2.0 D

Purpose To identify corneal epithelial- and stromal-thickness distribution patterns in keratoconus using spectral-domain optical coherence tomography (SD-OCT). Patients and Methods We analyzed SD-OCT findings in 20 confirmed cases of keratoconus (group 1) and in 20 healthy subjects with corneal astigmatism ≥2 D (group 2). Epithelial and stromal thicknesses were measured at 11 ...

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

Background Class III β-tubulin, Sox2, and Survivin play important roles in tumor survival and proliferation. However, the association of these three factors with clinicopathological characteristics, chemoresistance, and survival in patients with ovarian cancer remains controversial. Methods We investigated the predictive value and correlation among the expression levels of Class ...

Pore structure and tracer migration behavior of typical American and Chinese shales

With estimated shale gas resources greater than those of US and Canada combined, China has been embarking on an ambitious shale development program. However, nearly 30 years of American experience in shale hydrocarbon exploration and production indicates a low total recovery of shale gas at 12 %–30 % and tight oil at 5 %–10 %. One of the main barriers to sustainable development of ...

Hepatitis C virus infection and the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma: evidence from a systematic review and meta-analysis of 16 case-control studies

Background Studies investigating the association between hepatitis C virus (HCV) infections and the occurrence of cholangiocarcinoma (CCA), especially intrahepatic cholangiocarcinoma (ICC), have shown inconsistent findings. Although previous meta-analyses referred to HCV and CCA, they mainly focused on ICC rather than CCA or extrahepatic cholangiocarcinoma (ECC). Since then, ...

Identification and Comparative Expression Profiles of Chemoreception Genes Revealed from Major Chemoreception Organs of the Rice Leaf Folder, Cnaphalocrocis medinalis (Lepidoptera: Pyralidae)

To better understand the olfactory mechanisms in the rice leaf folder, Cnaphalocrocis medinalis (Guenée), a serious pest of rice in Asia, we established six partial transcriptomes from antennae, protarsus, and reproductive organs of male and female adults. A total of 102 transcripts were identified, including 29 odorant receptors (ORs), 15 ionotropic receptors (IRs), 30 ...