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BackgroundOsteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a primary mediator of local inflammatory processes in OA. Current therapies for OA mainly focus on the symptoms of the advanced stage of the disease. The possible...

, Lingbo Kong.
Formal analysis: Ruize Yang.
Investigation: Dingjun Hao, **Wenjie** **Gao**, Lingbo Kong.
Methodology: Dingjun Hao, Biao Wang.
Project administration: Biao Wang.
Resources: Biao Wang, Hua Guo ... , Yongyi Wang.
Software: **Wenjie** **Gao**, Hua Guo.
Supervision: Biao Wang, Lingbo Kong.
Validation: Lingbo Kong.
Visualization: **Wenjie** **Gao**, Hua Guo.
Writing ± original draft: Ziqi Zhu, Biao Wang.
Writing

Monitoring glycosylation of the mAbs have been emphasized and routinely characterized in biopharmaceutical industries because the carbohydrate components are closely related to the safety, efficacy, and consistency of the antibodies. In this study, the comprehensive glycan profiling of a biosimilar candidate of cetuximab was successfully characterized using Normal phase high...

The aim of this paper is to deal with the existence and nonexistence of weak solutions to the initial and boundary value problem for u t = div ( | ∇ u | p ( x , t ) − 2 ∇ u + b ( x , t ) ∇ u ) + f ( u ) . By constructing suitable function spaces and applying the method of Galerkin’s approximation as well as weak convergence techniques, the authors prove the existence of local...

The authors investigate a degenerate parabolic equation with delay and nonlocal term, which describes slow diffusive processes in physics or biology. The existence of a nonnegative nontrivial periodic solution is obtained through the use of the Leray-Schauder degree method.MSC: 35D05, 35K55.

The collagen type II alpha 1 (COL2A1) mutation causes severe skeletal malformations, but the pathogenic mechanisms of how this occurs are unclear. To understand how this may happen, a col2a1 p.Gly1170Ser mutated mouse model was constructed and in homozygotes, the chondrodysplasia phenotype was observed. Misfolded procollagen was largely synthesized and retained in dilated...

The authors of this paper deal with the existence of weak solutions to the homogenous boundary value problem for the equation −div(|∇u|p−2∇u)=f(x)uα with f∈Lm(Ω) and α⩾1. The authors prove the existence of solutions in W01,p(Ω) for suitable m and α.MSC: 35J62, 35B25, 76D03.

The authors of this paper study a nonlinear viscoelastic equation with variable exponents. By using the Faedo-Galerkin method and embedding theory, the existence of weak solutions is given to the initial and boundary value problem under suitable assumptions.

The aim of this paper is to study the existence and extinction of weak solutions of the initial and boundary value problem for u t = div ( ( | u | σ ( x , t ) + d 0 ) | ∇ u | p ( x , t ) − 2 ∇ u ) + f ( x , t , u ) . First, the authors apply the method of parabolic regularization and Galerkin’s method to prove the existence of solutions to the problem mentioned and then obtain...

In this paper, the existence and blow-up property of solutions to an initial and boundary value problem for a nonlinear parabolic system with variable exponents is studied. Meanwhile, the blow-up property of solutions for a nonlinear hyperbolic system is also obtained.

In this paper, a nonlocal initial value problem to a p-Laplacian equation on time scales is studied. The existence of solutions for such a problem is obtained by using the topological degree method.

Background Adolescent idiopathic scoliosis (AIS) is one of the most common spinal deformities found in adolescent populations. Recently, a genome-wide association study (GWAS) in a Japanese population indicated that three single nucleotide polymorphisms (SNPs), rs11190870, rs625039 and rs11598564, all located near the LBX1 gene, may be associated with AIS susceptibility [1]. This...

Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported. We took a series of case-control studies, trying to understand whether Leptin gene polymorphisms are involved in the etiology of the AIS or the change in leptin level...

The aim of this paper is to study a fourth-order separated boundary value problem with the right-hand side function satisfying one-sided Nagumo-type condition. By making a series of a priori estimates and applying lower and upper functions techniques and Leray-Schauder degree theory, the authors obtain the existence and location result of solutions to the problem.