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Search: authors:"Wilson Truccolo"

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Interaction between synaptic inhibition and glial-potassium dynamics leads to diverse seizure transition modes in biophysical models of human focal seizures

How focal seizures initiate and evolve in human neocortex remains a fundamental problem in neuroscience. Here, we use biophysical neuronal network models of neocortical patches to study how the interaction between inhibition and extracellular potassium ([K +] o ) dynamics may contribute to different types of focal seizures. Three main types of propagated focal seizures observed in ...