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22 papers found.
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Linearity of holographic entanglement entropy

We consider the question of whether the leading contribution to the entanglement entropy in holographic CFTs is truly given by the expectation value of a linear operator as is suggested by the Ryu-Takayanagi formula. We investigate this property by computing the entanglement entropy, via the replica trick, in states dual to superpositions of macroscopically distinct geometries...

Deriving covariant holographic entanglement

We provide a gravitational argument in favour of the covariant holographic entanglement entropy proposal. In general time-dependent states, the proposal asserts that the entanglement entropy of a region in the boundary field theory is given by a quarter of the area of a bulk extremal surface in Planck units. The main element of our discussion is an implementation of an...

Explicitly broken supersymmetry with exactly massless moduli

The AdS/CFT correspondence is applied to an analogue of the little hierarchy problem in three-dimensional supersymmetric theories. The bulk is governed by a super-gravity theory in which a U(1) × U(1) R-symmetry is gauged by Chern-Simons fields. The bulk theory is deformed by a boundary term quadratic in the gauge fields. It breaks SUSY completely and sources an exactly marginal...

Generalized gravitational entropy from total derivative action

We investigate the generalized gravitational entropy from total derivative terms in the gravitational action. Following the method of Lewkowycz and Maldacena, we find that the generalized gravitational entropy from total derivatives vanishes. We compare our results with the work of Astaneh, Patrushev, and Solodukhin. We find that if total derivatives produced nonzero entropy, the...

Holographic entanglement entropy for general higher derivative gravity

Xi Dong 0 0 Stanford Institute for Theoretical Physics, Department of Physics, Stanford University , Stanford, CA 94305, U.S.A We propose a general formula for calculating the entanglement entropy

Tangshen formula attenuates diabetic renal injuries by upregulating autophagy via inhibition of PLZF expression

The Chinese herbal granule Tangshen Formula (TSF) has been proven to decrease proteinuria and improve estimated glomerular filtration rate (eGFR) in diabetic kidney disease (DKD) patients. However, the underlying mechanism of TSF on treatment of diabetic nephropathy (DN) remains unclear. The present study aimed to identify the therapeutic target of TSF in diabetic renal injuries...

Shape dependence of holographic Rényi entropy in general dimensions

We present a holographic method for computing the response of Rényi entropies in conformal field theories to small shape deformations around a flat (or spherical) entangling surface. Our strategy employs the stress tensor one-point function in a deformed hyperboloid background and relates it to the coefficient in the two-point function of the displacement operator. We obtain...

Bulk locality and quantum error correction in AdS/CFT

We point out a connection between the emergence of bulk locality in AdS/CFT and the theory of quantum error correction. Bulk notions such as Bogoliubov transformations, location in the radial direction, and the holographic entropy bound all have natural CFT interpretations in the language of quantum error correction. We also show that the question of whether bulk operator...

Holographic RG flows with nematic IR phases

We construct zero-temperature geometries that interpolate between a Lifshitz fixed point in the UV and an IR phase that breaks spatial rotations but preserves translations. We work with a simple holographic model describing two massive gauge fields coupled to gravity and a neutral scalar. Our construction can be used to describe RG flows in non-relativistic, strongly coupled...

Holographic reconstruction of general bulk surfaces

We propose a reconstruction of general bulk surfaces in any dimension in terms of the differential entropy in the boundary field theory. In particular, we extend the proof of Headrick et al. to calculate the area of a general class of surfaces, which have a 1-parameter foliation over a closed manifold. The area can be written in terms of extremal surfaces whose boundaries lie on...

Association of 677 C>T (rs1801133) and 1298 A>C (rs1801131) Polymorphisms in the MTHFR Gene and Breast Cancer Susceptibility: A Meta-Analysis Based on 57 Individual Studies

Individual Studies Kai Li 0 Wusheng Li 0 Xi Dong 0 Amanda E. Toland, Ohio State University Medical Center, United States of America 0 Department of Oncology, Shengjing Hospital of China Medical University

New solutions with accelerated expansion in string theory

We present concrete solutions with accelerated expansion in string theory, requiring a small, tractable list of stress energy sources. We explain how this construction (and others in progress) evades previous no go theorems for simple accelerating solutions. Our solutions respect an approximate scaling symmetry and realize discrete sequences of values for the equation of state...

Isorhamnetin Attenuates Atherosclerosis by Inhibiting Macrophage Apoptosis via PI3K/AKT Activation and HO-1 Induction

Background and Purpose Isorhamnetin (Iso) is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L. Previous studies have revealed its anti-cancer, anti-inflammatory, and anti-oxidant activities. This study investigated the ability of Iso to inhibit oxidized low-density lipoprotein (ox-LDL)-induced cell apoptosis in THP-1-derived macrophages. The effects of...

Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Rats

Objective Inflammation and fibrosis are essential promoters in the pathogenesis of diabetic nephropathy (DN) in type 2 diabetes. The present study examined the anti-inflammation and anti-fibrosis effect of Tangshen Formula (TSF), a traditional Chinese medicine, on DN. Research Design and Methods Protective role of TSF in DN was examined in a rat model of type 2 DN that was...

Characterization of Transcriptional Repressor Gene MSX1 Variations for Possible Associations with Congenital Heart Diseases

Background The human heart consists of several cell types with distinct lineage origins. Interactions between these cardiac progenitors are very important for heart formation. The muscle segment homeobox gene family plays a key role in the cell morphogenesis and growth, controlled cellular proliferation, differentiation, and apoptosis, but the relationships between the genetic...

Moduli stabilization and the holographic RG for AdS and dS

We relate moduli stabilization (V ′ = 0) in the bulk of AdS D or dS D to basic properties of the Wilsonian effective action in the holographic dual theory on dSD−1: the single-trace terms in the action have vanishing beta functions, and higher-trace couplings are determined purely from lower-trace ones. In the de Sitter case, this encodes the maximal symmetry of the bulk...

Altered microRNAs expression profiling in cumulus cells from patients with polycystic ovary syndrome

Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence is altered in patients with PCOS. In recent years microRNAs (miRNAs) have emerged as important regulators of gene expression, the aim of the study was to study miRNAs expression patterns of cumulus cells from PCOS patients. Methods The study...

Aspects of holography for theories with hyperscaling violation

We analyze various aspects of the recently proposed holographic theories with general dynamical critical exponent z and hyperscaling violation exponent θ. We first find the basic constraints on z, θ from the gravity side, and compute the stress-energy tensor expectation values and scalar two-point functions. Massive correlators exhibit a nontrivial exponential behavior at long...