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115 papers found.
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Transcriptome variations among human embryonic stem cell lines are associated with their differentiation propensity

administration: Changbin Sun, Jiawen Zhang. Resources: Jian Wang. Supervision: Huanming Yang, Xi Zhang. Validation: Huanming Yang. Writing ± original draft: Changbin Sun. Writing ± review & editing: Xi Zhang

A chance-constrained stochastic approach to intermodal container routing problems

Zhao. Formal analysis: Yi Zhao. Funding acquisition: Xi Zhang. Investigation: Yi Zhao. Methodology: Yi Zhao, Ronghui Liu. Supervision: Ronghui Liu. Writing ± original draft: Yi Zhao. Writing

Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis

Contributions Conceptualization: Shyamasundaran Kottilil. Data curation: Shyamasundaran Kottilil. Formal analysis: Benjamin Emmanuel, Shyamasundaran Kottilil. Investigation: Cheol-Woo Kim, Alison Murphy, Xi ... Zhang, Michael Sneller, Shyamasundaran Kottilil. Methodology: Shyamasundaran Kottilil. Supervision: Shyamasundaran Kottilil. Validation: Shyamasundaran Kottilil. Visualization: Shyamasundaran

Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

the topic and contributed to manuscript editing. SS supervised the research. All authors read and approved the final manuscript. Compliance with Ethical Standards Conflict of Interest Xi Zhang, Simone

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

Objective The aim of this study was used meta-analysis to investigate changes of serum tumor necrosis factor-alpha (TNF-α) in patients with type 1 diabetes mellitus (T1DM). Methods Relevant literatures were identified from PubMed, Cochrane Library, CNKI, WanFang and Chinese-Cqvip databases (published from January 1, 1999 to September 30, 2016). Eligible reports were included for...

Efficient path routing strategy for flows with multiple priorities on scale-free networks

In real networks, traffic flows are different in amount as well as their priorities. However, the latter priority has rarely been examined in routing strategy studies. In this paper, a novel routing algorithm, which is based on the efficient path routing strategy (EP), is proposed to overcome network congestion problem caused by large amount of traffic flows with different...

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

Background We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk factor and complication of cardiac surgery. In this study, we investigate whether EMPs increase in congenital heart diseases to promote inflammation and...

miR-589-5p inhibits MAP3K8 and suppresses CD90 + cancer stem cells in hepatocellular carcinoma

Background Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133 + and EpCAM + CSCs in HCC, although it is unclear whether miRNAs regulate CD90 + CSCs in HCC. Methods The miRNA profiles of CD90 + and CD90 - HCC cells were analyzed using a miRNA microarray and...

Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming

Scientists of State Key Laboratory of Agrobiotechnology 2015SKLAB6-15. Xi Zhang, Xinglin Wei, Yuanyuan Wu, Yuzhe Wang, Cheng Tan, Xiaoxiang Hu, Ning Li, Mario R. Capecchi and Sen Wu declare that they have no ... Li1, Mario R. Capecchi2, Sen Wu1& Xi Zhang, Xinglin Wei, and Yuanyuan Wu have contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s13238

Antifungal prophylaxis of patients undergoing allogenetic hematopoietic stem cell transplantation in China: a multicenter prospective observational study

Background Antifungal prophylaxis is currently regarded as the gold standard in situations with allo-genetic hematopoietic stem cell transplantation (allo-HSCT). However, the epidemiological information regarding prophylaxis of invasive fungal diseases (IFDs) is not clear in China. Methods We report the first large-scale (1053 patients) observational study of the prophylaxis and...

Different Antibody Response against the Coxsackievirus A16 VP1 Capsid Protein: Specific or Non-Specific

Coxsackievirus A16 (CA16) is one of the major causative agents of hand, foot, and mouth disease worldwide. The non-neutralizing antibody response that targets CA16 VP1 remains poorly elucidated. In the present study, antibody responses against CA16 VP1 in Shanghai blood donors and Shanxi individuals were analyzed by ELISA and inhibitory ELISA using five CA16 VP1 antigens: VP11...

Seminal fluid protein genes of the brown planthopper, Nilaparvata lugens

Background Seminal fluid proteins (SFPs) are produced mainly in the accessory gland of male insects and transferred to females during mating, in which they induce numerous physiological and post-mating behavioral changes. The brown plant hopper (BPH), Nilaparvata lugens, is an economically important hemipterous pest of rice. The behavior and physiology of the female of this...

Renin–angiotensin system blockade for the risk of cancer and death

Wei Ling Min-Hui Zhu Xiao-Xi Zhang Yi Sui Hai-Lu Zhao Introduction: The effects of renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1

JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE

Background Although most studies on treatments for eosinophilic esophagitis (EoE) have focused on effects in the epithelium, EoE is a transmural disease. Eosinophils that infiltrate the subepithelial layers of the esophagus lead to fibrosis and the serious complications of EoE, and current therapies have shown minimal effects on this fibrosis. We aimed to elucidate T helper (Th)2...

Perfusion Deficits and Functional Connectivity Alterations in Memory-Related Regions of Patients with Post-Traumatic Stress Disorder

To explore the potential alterations in cerebral blood flow (CBF) and functional connectivity of recent onset post-traumatic stress disorder (PTSD) induced by a single prolonged trauma exposure, we recruited 20 survivors experiencing the same coal mining flood disaster as the PTSD (n = 10) and non-PTSD (n = 10) group, respectively. The pulsed arterial spin labeling (ASL) images...

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X 7 receptor in dorsal root ganglia

Background Long non-protein-coding RNAs (lncRNAs) are involved in the pathological processes of nervous system diseases. NONRATT021972 is an lncRNA. This study explores the effects of lncRNA NONRATT021972 small interference RNA (siRNA) on diabetic neuropathic pain (DNP) mediated by the P2X 7 receptor in the rat dorsal root ganglia (DRG). Results Our results show that...

A Novel Supra-Brow Combined with Infra-Brow Lift Approach for Asian Women

Background Direct brow lift surgery remains popular among Asian women despite its disadvantages. The traditional direct brow lift by a supra-brow incision is not suitable for Asian women because of their unique facial features, such as higher eyebrows, wider upper eyelids, and more orbital fat. Therefore, we designed a novel brow lift technique via a supra-brow combined with an...

Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection

A rapid expansion of HFMD with enterovirus 71 infection outbreaks has occurred and caused deaths in recent years in China, but no vaccine or antiviral drug is currently available for EV71 infection. This study aims to provide treatment programs for HFMD patients. We conducted a randomized, double-blind, controlled trial and evaluated clinical efficacy of therapy with rHuIFN-α1b...

The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer

Background Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer. Methods We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues...