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A Five-Year Prospective Study of Diabetic Retinopathy Progression in Chinese Type 2 Diabetes Patients with “Well-Controlled” Blood Glucose

Purpose To determine the progression rate and risk factors for diabetic retinopathy (DR) in Chinese type 2 diabetic patients who have reached the target hemoglobin A1c (HbA1c) level recommended by the American Diabetes Association. Methods This was a 5-year community-based prospective study. The study population consisted of patients with type 2 diabetes with HbA1c less than 7.0...

A Novel Supra-Brow Combined with Infra-Brow Lift Approach for Asian Women

Background Direct brow lift surgery remains popular among Asian women despite its disadvantages. The traditional direct brow lift by a supra-brow incision is not suitable for Asian women because of their unique facial features, such as higher eyebrows, wider upper eyelids, and more orbital fat. Therefore, we designed a novel brow lift technique via a supra-brow combined with an...

A Wideband Dual-Polarized Antenna Using Planar Quasi-Open-Sleeve Dipoles for Base Station Applications

, Xidian University, Xi’an, Shaanxi 710071, China Received 2 May 2015; Accepted 27 July 2015 Academic Editor: Herve Aubert Copyright © 2015 Guan-xi Zhang et al. This is an open access article

A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model

, Yunfeng Xia, Xi Zhang, Liqun Chen, Chen Zhao, Shifeng Huang, Jiayan Lei, Yixiao Feng, Wei Liu & Hua GanMolecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The ... for Xi Zhang in:Nature Research journals • PubMed • Google Scholar Search for Liqun Chen in:Nature Research journals • PubMed • Google Scholar Search for Shujuan Yan in:Nature Research journals

A case report of avian influenza H7N9 killing a young doctor in Shanghai, China

Background The novel avian influenza H7N9 virus has caused severe diseases in humans in eastern China since the spring of 2013. On January 18 th 2014, a doctor working in the emergency department of a hospital in Shanghai died of H7N9 virus infection. To understand possible reasons to explain this world’s first fatal H7N9 case of a health care worker (HCW), we summarize the...

A chance-constrained stochastic approach to intermodal container routing problems

Zhao. Formal analysis: Yi Zhao. Funding acquisition: Xi Zhang. Investigation: Yi Zhao. Methodology: Yi Zhao, Ronghui Liu. Supervision: Ronghui Liu. Writing ± original draft: Yi Zhao. Writing

A reported death case of a novel bunyavirus in Shanghai, China

This paper describes the first case of infection with a recently described novel bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), in Shanghai, China. The case is originally from Chizhou City, Anhui province within an endemic area for SFTSV. We describe the etiology, epidemiological characteristics, clinical diagnosis and treatment of this fatal case. This...

Aberrant intra- and inter-network connectivity architectures in Alzheimer’s disease and mild cognitive impairment

• Google ScholarSearch for Luning Wang in:Nature Research journals • PubMed • Google ScholarSearch for Ningyu An in:Nature Research journals • PubMed • Google ScholarSearch for Xi Zhang in:Nature Research ... Correspondence to Xi Zhang or Yong Liu. Supplementary information Word documents1.Supplementary Information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0

Aerosol influence on energy balance of the middle atmosphere of Jupiter

Sciences, California Institute of Technology, Pasadena, California 91125, USAYuk L. Yung AuthorsSearch for Xi Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Robert A. West in:Nature ... authors declare no competing financial interests. Corresponding author Correspondence to Xi Zhang. Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International

All-trans retinoic acid arrests cell cycle in leukemic bone marrow stromal cells by increasing intercellular communication through connexin 43-mediated gap junction

Background Gap junctional intercellular communication (GJIC) is typically decreased in malignant tumors. Gap junction is not presented between hematopoietic cells but occurred in bone marrow stromal cells (BMSCs). Connexin 43 (Cx43) is the major gap junction (GJ) protein; our previous study revealed that Cx43 expression and GJIC were decreased in acute leukemic BMSCs. All-trans...

An Elevated Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Colorectal Cancer: A Meta-Analysis

Background. The aims of this study were to evaluate the clinicopathological and prognostic values of platelet-to-lymphocyte ratio (PLR) in colorectal cancer (CRC). Methods. The PubMed and Embase databases and the references of relevant studies were systematically searched. This study was performed with hazard ratios (HRs) and odd ratios (ORs) with corresponding 95% confidence...

An Inhibitory Effect of Extracellular Ca2+ on Ca2+-Dependent Exocytosis

Aim Neurotransmitter release is elicited by an elevation of intracellular Ca2+ concentration ([Ca2+]i). The action potential triggers Ca2+ influx through Ca2+ channels which causes local changes of [Ca2+]i for vesicle release. However, any direct role of extracellular Ca2+ (besides Ca2+ influx) on Ca2+-dependent exocytosis remains elusive. Here we set out to investigate this...

An Online Multisensor Data Fusion Framework for Radar Emitter Classification

Radar emitter classification is a special application of data clustering for classifying unknown radar emitters in airborne electronic support system. In this paper, a novel online multisensor data fusion framework is proposed for radar emitter classification under the background of network centric warfare. The framework is composed of local processing and multisensor fusion...

Antifungal prophylaxis of patients undergoing allogenetic hematopoietic stem cell transplantation in China: a multicenter prospective observational study

Background Antifungal prophylaxis is currently regarded as the gold standard in situations with allo-genetic hematopoietic stem cell transplantation (allo-HSCT). However, the epidemiological information regarding prophylaxis of invasive fungal diseases (IFDs) is not clear in China. Methods We report the first large-scale (1053 patients) observational study of the prophylaxis and...

Antiviral Drug Therapy of Filovirus Infections: S-Adenosylhomocysteine Hydrolase Inhibitors Inhibit Ebola Virus In Vitro and in a Lethal Mouse Model

Ebola (subtype Zaire) viral replication was inhibited in vitro by a series of nine nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase, an important target for antiviral drug development. Adult BALB/c mice lethally infected with mouse-adapted Ebola virus die 5–7 days after infection. Treatment initiated on day 0 or 1 resulted in dose-dependent protection, with...

Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with Dot1l deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated Aqp5 as the most upregulated gene in Dot1lAC vs. control mice. Aqp5 protein is barely...

CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data

, Gene Expression Data, and Mutation Data Kelvin Xi Zhang 0 B. F. Francis Ouellette 0 John Quackenbush, Dana-Farber Cancer Institute, United States of America 0 1 Graduate Program in Bioinformatics

CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients

Zhonghu Li 0 Kai Chen 0 Peng Jiang Xi Zhang Xiaowu Li Zhihua Li 0 Equal contributors Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University , 30

Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

 Lan He,3 Xue-zhi Hong,1 Fang Tian,2 Yan-hong Pan,1 Ling Liang,1 Xiao-xi Zhang,1,4 and Hai-lu Zhao1,2,4 1Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University ... data, and wrote the first daft. Jian Shen directed statistical analyses of the data and designed the study. Lan He, Xue-zhi Hong, Fang Tian, Yan-hong Pan, Ling Liang, and Xiao-xi Zhang analyzed and

Characterisation of a Novel White Laccase from the Deuteromycete Fungus Myrothecium verrucaria NF-05 and Its Decolourisation of Dyes

A novel ‘white’ laccase was purified from the deuteromycete fungus, Myrothecium verrucaria NF-05, which was a high laccase-producing strain (40.2 U·ml−1 on the thirteenth day during fermentation). SDS-PAGE and native-PAGE revealed a single band with laccase activity corresponding to a molecular weight of approximately 66 kDa. The enzyme had three copper and one iron atoms per...