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Liraglutide and Metformin alone or combined therapy for type 2 diabetes patients complicated with coronary artery disease

This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated...

Liraglutide and Metformin alone or combined therapy for type 2 diabetes patients complicated with coronary artery disease

This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated...

Modeling miRNA-mRNA interactions that cause phenotypic abnormality in breast cancer patients

Conceptualization: Xia Jiang. Data curation: Sanghoon Lee, Xia Jiang. Formal analysis: Sanghoon Lee, Xia Jiang. Funding acquisition: Xia Jiang. Investigation: Sanghoon Lee, Xia Jiang. Methodology: Sanghoon Lee ... , Xia Jiang. Project administration: Xia Jiang. Resources: Xia Jiang. Supervision: Xia Jiang. Validation: Sanghoon Lee. Writing ± original draft: Sanghoon Lee, Xia Jiang. Writing ± review & editing

Computational methods for ubiquitination site prediction using physicochemical properties of protein sequences

Background Ubiquitination is a very important process in protein post-translational modification, which has been widely investigated by biology scientists and researchers. Different experimental and computational methods have been developed to identify the ubiquitination sites in protein sequences. This paper aims at exploring computational machine learning methods for the...

Discovering causal interactions using Bayesian network scoring and information gain

Zexian Zeng is a Ph.D. student in bioinformatics at the Northwestern University Feinberg School of Medicine. Xia Jiang is assistant professor of biomedical informatics at the University of Pittsburgh. She

Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis

Background Noninvasive methods to accurately and conveniently evaluate liver fibrosis are desirable. MicroRNA (miR) is one of the candidates. MiRs are small RNAs consisting of 19–25 nucleotides that negatively regulate many target genes at transcriptional levels. Recently, many researchers have focused on circulating miRs in the blood stream as biomarkers. Hepatic miR-122 has...

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study

Background To prevent debilitating and irreversible joint damage, rheumatoid arthritis (RA) is often treated with tumor necrosis factor inhibitor (TNFi), but many patients do not respond to this costly therapy. Few predictors for response are known, and it has been proposed that genetic factors which influence the development of RA may also influence disease severity and response...

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study

Background To prevent debilitating and irreversible joint damage, rheumatoid arthritis (RA) is often treated with tumor necrosis factor inhibitor (TNFi), but many patients do not respond to this costly therapy. Few predictors for response are known, and it has been proposed that genetic factors which influence the development of RA may also influence disease severity and response...

Learning Predictive Interactions Using Information Gain and Bayesian Network Scoring

Background The problems of correlation and classification are long-standing in the fields of statistics and machine learning, and techniques have been developed to address these problems. We are now in the era of high-dimensional data, which is data that can concern billions of variables. These data present new challenges. In particular, it is difficult to discover predictive...

Pan-cancer analysis of TCGA data reveals notable signaling pathways

Intelligent Systems, served to establish the field we now call Bayesian networks. Xia Jiang is assistant professor of biomedical informatics in the Department of Biomedical Informatics at the University of

Study of Integrated Heterogeneous Data Reveals Prognostic Power of Gene Expression for Breast Cancer Survival

Background Studies show that thousands of genes are associated with prognosis of breast cancer. Towards utilizing available genetic data, efforts have been made to predict outcomes using gene expression data, and a number of commercial products have been developed. These products have the following shortcomings: 1) They use the Cox model for prediction. However, the RSF model has...

Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012

This present study aims to determine trends in the prevalence of H. pylori infections in Southeastern China between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. This retrospective study screened 196,442 patients with a mean age of 47.49 ± 14.47 years (age range 5–100 years) in Southeastern China, and a total of 134,812...

Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction

. AffiliationsDepartment of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, ChinaHao Zhang, Hongliang Hui, Zhimin Li, Jiajun Pan, Xia Jiang, Tengteng Wei, Huazhu Cui ... Jiajun Pan in:Nature Research journals • PubMed • Google ScholarSearch for Xia Jiang in:Nature Research journals • PubMed • Google ScholarSearch for Tengteng Wei in:Nature Research journals • PubMed

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register

Introduction Whether low socioeconomic status (SES) is associated with worse rheumatoid arthritis (RA) outcomes in countries with general tax-financed healthcare systems (such as Sweden) remains to be elucidated. Our aim was to investigate the influence of educational background (achieving university/college degree (high) or not (low)) on the outcomes of early RA, in terms of...

Mortality among drowning rescuers in China, 2013: a review of 225 rescue incidents from the press

and Xia Jiang share first-authorship. Acknowledgements The authors thank Pengpeng Ye and Ziyang Yu for their generous contributions during revisions of this paper. 1. van Beeck EF , Branche CM

MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells

MicroRNA-122 (miR-122) is one of the most abundant miRs in the liver. Previous studies have demonstrated that miR-122 plays a role in inflammation in the liver and functions in hepatic stellate cells (HSCs), which reside in the space of Disse. Here, we showed that the transient inhibition of PKR-activating protein (PACT) expression, by miR-122 or siRNA targeting of PACT...

Hepatitis C Virus Nonstructural Protein 5A Inhibits Thapsigargin-Induced Apoptosis

Background We previously reported that the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) down-regulates TLR4 signaling and lipopolysaccharide-induced apoptosis of hepatocytes. There have been several reports regarding the association between HCV infection and endoplasmic reticulum (ER) stress. Here, we examined the regulation of HCV NS5A on the apoptosis of hepatocytes...

Mining Pure, Strict Epistatic Interactions from High-Dimensional Datasets: Ameliorating the Curse of Dimensionality

Background The interaction between loci to affect phenotype is called epistasis. It is strict epistasis if no proper subset of the interacting loci exhibits a marginal effect. For many diseases, it is likely that unknown epistatic interactions affect disease susceptibility. A difficulty when mining epistatic interactions from high-dimensional datasets concerns the curse of...

Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1

Angeles, California, 90033, USAXiao-Xia Jiang, YuChia Chou, Lindsey Jones, Tao Wang, Suzi Sanchez, Xue F Huang & Si-Yi ChenDepartment of Advanced Interdisciplinary Studies, Institute of Basic Medical ... Sciences, Beijing, 100850, ChinaXiao-Xia Jiang, Lei Zhang & Changyong Wang AuthorsSearch for Xiao-Xia Jiang in:Nature Research journals • PubMed • Google ScholarSearch for YuChia Chou in:Nature Research

Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-κB-Nuclear Translocation

Background Hepatitis C virus (HCV) infection is one of the major causes of cirrhosis and hepatocellular carcinoma. HCV nonstructural protein 5A (NS5A) is an attractive antiviral target and plays an important role in HCV replication as well as hepatocarcinogenesis. The aim of this study was to assess the effect of HCV NS5A protein in the abrogation of apoptotic cell death induced...