Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities. However, its effect on astrocyte senescence in PD remains to be defined. Long culture-induced replicative senescence model and 1-methyl-4...
Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation in humans. It is deeply involved in many pathophysiological processes and serves as an attractive target for the treatment of cardiovascular, neoplastic, autoimmune, neurodegenerative, inflammatory, and...
, Lei Jiang. Formal analysis: Zhaoyu Gao. 20 / 24 Funding acquisition: Shunjiang Xu. Methodology: Lei Jiang. Project administration: Rui Zhang. Resources: Xia Jiang. Software: Wanchang Wang
Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass. We performed multivariable regression analyses to assess the association of birth weight with bone parameters measured by dual-energy X-ray absorptiometry (DXA) and by quantitative...
A novel nitrogen-containing graphitic mesoporous carbon was prepared through MnO-templated method using polyacrylonitrile (PAN) as both carbon and nitrogen sources, and MnCO3 as both template and catalyst precursors. The effects of preparation conditions on the physicochemical properties of obtained samples were systematically investigated. The results showed that as the decrease...
This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated...
This study is to compare the effects of Liraglutide and Metformin alone or combined treatment on the cardiac function in T2DM patients complicated with CAD. 120 T2DM patients were included at Endocrinology Department of Tianjin First Center Hospital (Tianjin, China) from April 2012 to September 2013. The study contained two sections. Section 1: 30 patients in group 1 was treated...
Huang of Fudan University for providing the C. difficile RT078 strain. Author Contributions Data curation: Hong-Xia Jiang. Formal analysis: Li-Juan Zhang, Hong-Xia Jiang. Investigation: Xi-Xi Gu ... . Methodology: Li-Juan Zhang, Xi-Xi Gu, Pin-Xian Chen, Jia-Li Fu. Writing ? original draft: Li-Juan Zhang. Writing ? review & editing: Ling Yang, Hong-Xia Jiang. 9 / 11 10 / 11 1. Knight DR , Elliott B , Chang
Recent progresses in proton exchange membrane fuel cell electrocatalysts are reviewed in this article in terms of cathodic and anodic reactions with a focus on rational design. These designs are based around gaining active sites using model surface studies and include high-index faceted Pt and Pt-alloy nanocrystals for anodic electrooxidation reactions as well as Pt-based alloy...
and Xia Jiang share first-authorship. Acknowledgements The authors thank Pengpeng Ye and Ziyang Yu for their generous contributions during revisions of this paper. 1. van Beeck EF , Branche CM
AuthorsSearch for Yinchao Zhu in:PubMed • Google Scholar Search for Xia Jiang in:PubMed • Google Scholar Search for Hui Li in:PubMed • Google Scholar Search for Fudong Li in:PubMed • Google Scholar Search for ... Yinchao Zhu and Xia Jiang share first-authorship. Yinchao Zhu and Xia Jiang contributed equally to this work. Rights and permissions This article is published under license to BioMed Central Ltd
This present study aims to determine trends in the prevalence of H. pylori infections in Southeastern China between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. This retrospective study screened 196,442 patients with a mean age of 47.49 ± 14.47 years (age range 5–100 years) in Southeastern China, and a total of 134,812...
BackgroundCognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD.MethodsThirty-seven patients with BD...
Ming-Yue Fang 0 Chong Zhang 0 Song Yang Jin-Yu Cui Pei-Xia Jiang Kai Lou Masaaki Wachi Xin-Hui Xing 0 0 Department of Chemical Engineering, Tsinghua University , Beijing 10084 , China Background
Background Epiretinal implants based on microelectro-mechanical system (MEMS) technology with a polyimide (PI) material are being proposed for application. Many kinds of non-photosensitive PIs have good biocompatibility and stability as typical MEMS materials for implantable electrodes. However, the effects of MEMS microfabrication, sterilization and implantation using a...
Background Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein that is highly expressed in cardiomyocytes. A variety of peptides derived from PEDF exerts diverse physiological activities including anti-angiogenesis, antivasopermeability, and neurotrophic activities. Recent studies demonstrated that segmental functional peptides of PEDF, 44mer peptide (Val78...
The changes in the microbial community structure during acute exacerbations of severe chronic obstructive pulmonary disease (COPD) in hospitalized patients remain largely uncharacterized. Therefore, further studies focused on the temporal dynamics and structure of sputum microbial communities during acute exacerbation of COPD (AECOPD) would still be necessary. In our study, the...
Purpose Gemcitabine/taxanes-based combination shows anti-tumor activity for the treatment of metastatic breast cancer, but there is a debate regarding the advantages of gemcitabine and taxanes regimens as a first-line or second-line treatment for metastatic breast cancer. Here we conducted a systematic review and meta-analysis to compare the efficacy and toxicity for patients...
Cytochrome P-450 epoxygenase (EPOX)-derived epoxyeicosatrienoic acids (EETs), 5-lipoxygenase (5-LO), and leukotriene B4 (LTB4), the product of 5-LO, all play a pivotal role in the vascular inflammatory process. We have previously shown that EETs can alleviate oxidized low-density lipoprotein (ox-LDL)-induced endothelial inflammation in primary rat pulmonary artery endothelial...
Objectives To obtain a broad molecular epidemiological characterization of plasmid-mediated AmpC β-lactamase CMY-2 in Escherichia coli isolates from food animals in China. Methods A total of 1083 E. coli isolates from feces, viscera, blood, drinking water, and sub-surface soil were examined for the presence of CMY-2 β-lactamases. CMY-2-producing isolates were characterized as...
