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Evidence for maternal control of seed size in maize from phenotypic and transcriptional analysis

Seed size is an important component of grain yield and a key determinant trait for crop domestication. The Krug Yellow Dent long-term selection experiment for large and small seed provides a valuable resource to dissect genetic and phenotypic changes affecting seed size within a common genetic background. In this study, inbred lines derived from Krug Large Seed (KLS) and Krug...

The Toll-like Receptor 9 Ligand, CpG Oligodeoxynucleotide, Attenuates Cardiac Dysfunction in Polymicrobial Sepsis, Involving Activation of Both Phosphoinositide 3 Kinase/Akt and Extracellular-Signal-Related Kinase Signaling

Background. Toll-like receptors (TLRs) play a role in the pathophysiology of sepsis and multiple organ failure. This study examined the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis–induced cardiac dysfunction. Methods. Male C57BL/6 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior...

Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma

Background Aberrant activation of beta-catenin/TCF4 and STAT3 signaling in glioblastoma multiforme (GBM) has been reported. However, the molecular mechanisms related to this process are still poorly understood.

HOTAIR, a cell cycle–associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma

Background Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance and function of HOTAIR in glioma remains unclear.

Soybean GmbZIP123 gene enhances lipid content in the seeds of transgenic Arabidopsis plants

Soybean is one of most important oil crops and a significant increase in lipid content in soybean seeds would facilitate vegetable oil production in the world. Although the pathways for lipid biosynthesis in higher plants have been uncovered, our understanding of regulatory mechanism controlling lipid accumulation is still limited. In this study, we identified 87 transcription...

Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN

Background Altered expression of micro(mi)RNAs has been shown to be associated with tumorigenesis and tumor progression. The expression of phosphatase and tensin homolog (PTEN) plays an important role in glioma and is regarded as a prognostic marker of glioma patients. The goal of this study was to investigate the function of lethal (let)-7a miRNA in glioma cell lines with...

Support vector machines and kd-tree for separating quasars from large survey data bases

We compare the performance of two automated classification algorithms, k-dimensional tree (kd-tree) and support vector machines (SVMs), to separate quasars from stars in the data bases of the Sloan Digital Sky Survey (SDSS) and the Two-Micron All Sky Survey (2MASS) catalogues. The two algorithms are trained on subsets of SDSS and 2MASS objects whose nature is known via...

Astressin B, a Nonselective Corticotropin-Releasing Hormone Receptor Antagonist, Prevents the Inhibitory Effect of Ghrelin on Luteinizing Hormone Pulse Frequency in the Ovariectomized Rhesus Monkey

. Endocrinology 112 : 2076 - 2080 17. Vulliemoz NR , Xiao E , Xia-Zhang L , Germond M , Rivier J , Ferin M 2004 Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ... antalarmin: differing profiles of activity in rhesus monkeys . Neuropsychopharmacology 29 : 1112 - 1121 25. Xiao E , Xia-Zhang L , Vulliemoz N , Rivier J , Ferin M 2007 Astressin B , a corticotropin-releasing

Astressin B, a Corticotropin-Releasing Hormone Receptor Antagonist, Accelerates the Return to Normal Luteal Function after an Inflammatory-Like Stress Challenge in the Rhesus Monkey

Reprod 62 : 45 - 53 20. Smith RF , Ghuman SP , Evans NP , Karsch FJ , Dobson H 2003 Stress and the control of LH secretion in the ewe . Reprod Suppl 61 : 267 - 282 21. Xiao E , Xia-Zhang L , Barth A , Zhu ... Clin Endocrinol Metab 83 : 2454 - 2460 22. Xiao E , Xia-Zhang L , Ferin M 1999 Stress and the menstrual cycle: short- and long-term response to a five-day endotoxin challenge during the luteal phase in

Central Infusion of Agouti-Related Peptide Suppresses Pulsatile Luteinizing Hormone Release in the Ovariectomized Rhesus Monkey

male rats . Endocrinology 140 : 5459 - 5462 17. Xiao E , Xia-Zhang L , Vulliemoz NR , Ferin M , Wardlaw SL 2003 Agoutirelated protein stimulates the hypothalamic-pituitary-adrenal (HPA) axis and enhances ... ovariectomized rhesus monkey . Neuroendocrinology 59 : 336 - 342 19. Xiao E , Xia-Zhang L , Thornell D , Shalts E , Ferin M 1996 The luteinizing hormone but not the cortisol response to arginine vasopressin is

Decrease in Luteinizing Hormone Pulse Frequency during a Five-Hour Peripheral Ghrelin Infusion in the Ovariectomized Rhesus Monkey

macaques . Endocrinology 127 : 2437 - 2444 19. Vulliemoz NR , Xiao E , Xia-Zhang L , Wardlaw SL , Ferin M Central infusion of AGRP suppresses pulsatile release in ovariectomized rhesus monkeys . Program of ... and hormonal effects of human ghrelin in healthy volunteers . Am J Physiol Regul Integr Comp Physiol 280 : R1483 - R1487 33. Xiao E , Xia-Zhang L , Vulliemoz NR , Ferin M , Wardlaw SL 2003 Agoutirelated

Agouti-Related Protein Stimulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Enhances the HPA Response to Interleukin-1 in the Primate

RB , Cone RD 1993 Identification of a receptor for melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system . Proc Natl Acad Sci USA 90 : 8856 - 8860 22. Xiao E , Xia ... -Zhang L , Ferin M , Wardlaw SL 2001 Differential effects of estradiol on the adrenocorticotropin responses to interleukin-6 and interleukin-1 in the monkey . Endocrinology 142 : 2736 - 2741 23. Snider RS

Tonic Support of Luteinizing Hormone Secretion by Adrenal Progesterone in the Ovariectomized Monkey Replaced with Midfollicular Phase Levels of Estradiol

Although it is known that progesterone facilitates the estradiol-induced gonadotropin surge at midcycle, its effect on LH secretion at other times of the follicular phase remains to be investigated. In this study, we investigate the role of progesterone on tonic LH secretion in the ovariectomized primate replaced with estradiol at levels representative of the follicular phase...


— The regulation mechanism of inhibition of intestinal ethanol absorption induced by high acetaldehyde (AcH) concentration in blood was investigated. We used atropine (AT), atropine methylbromide (ATMB), pirenzepine (PI), bethanechol (BE) and pilocarpine (PL) with or without cyanamide (CY; a potent inhibitor of aldehyde dehydrogenase, which induces high AcH concentration in blood...

Formylpeptide Receptor FPR and the Rapid Growth of Malignant Human Gliomas

Background: The formylpeptide receptor (FPR) is a G-protein–coupled receptor (GPCR) that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLF). We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic...