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SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume

Genome-wide association studies have identified a genetic variant at 3p14.3 (SNP rs1354034) that strongly associates with platelet number and mean platelet volume in humans. While originally proposed to be intronic, analysis of mRNA expression in primary human hematopoietic subpopulations reveals that this SNP is located directly upstream of the predominantly expressed ARHGEF3 ...

Characteristics and accumulation model of the late Quaternary shallow biogenic gas in the modern Changjiang delta area, eastern China

The Changjiang (Yangtze) is one of the largest rivers in the world. It formed a huge incised valley at its mouth during the Last Glacial Maximum; the incised-valley fill, approximately 80–110 m thick, supplies an important foundation for the generation of shallow biogenic-gas reservoirs. Two cores and 13 cone penetration tests were used to elaborate the characteristics, formation ...

Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

Background Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney disease (CKD) patients in developed countries, limited information is available about CVD prevalence and risk factors in the Chinese CKD population. The Chinese Cohort of Chronic Kidney Disease (C-STRIDE) was established to investigate the prevalence and risk factors of CVD among ...

Self-catalyzed Growth of InAs Nanowires on InP Substrate

We report on the self-catalyzed growth of InAs nanowires on InP substrate by metal-organic chemical vapor deposition. At a moderate V/III ratio, tapered nanowires are obtained, suggesting a strong surface diffusion effect. Dense twin faults are observed perpendicular to the nanowire growth direction due to the fluctuation of In atoms in the droplet originating from the surface ...

Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies

Transgenic pigs have become an attractive research model in the field of translational research, regenerative medicine, and stem cell therapy due to their anatomic, genetic and physiological similarities with humans. The development of fluorescent proteins as molecular tags has allowed investigators to track cell migration and engraftment levels after transplantation. Here we ...

A High-Efficiency Si Nanowire Array/Perovskite Hybrid Solar Cell

A low-cost Si nanowire array/perovskite hybrid solar cell is proposed and simulated. The solar cell consists of a Si p-i-n nanowire array filled with CH3NH3PbI3, in which both the nanowires and perovskite absorb the incident light while the nanowires act as the channels for transporting photo-generated electrons and holes. The hybrid structure has a high absorption efficiency in a ...

Risk Factors for Complications after Reduction Mammoplasty: A Meta-Analysis

further article sources. Eligibility criteria The initial selection of studies was performed on the basis of titles and abstracts. Next, two investigators (Min-Xia Zhang and Chun-Ye Chen) independently ... (Min-Xia Zhang and Chun-Ye Chen), and any disagreement concerning paper eligibility was resolved by discussion and consensus. The data covered the general characteristics of each study and the outcomes

Analysis of the tensor–tensor type scalar tetraquark states with QCD sum rules

In this article, we study the ground states and the first radial excited states of the tensor–tensor type scalar hidden-charm tetraquark states with the QCD sum rules. We separate the ground state contributions from the first radial excited state contributions unambiguously, and obtain the QCD sum rules for the ground states and the first radial excited states, respectively. Then ...

Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment

Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1) into a regulatory ...

Establishment of an innovative staging system for extramedullary plasmacytoma

Background Extramedullary plasmacytoma (EMP) is a rare malignant disease that lacks a unique clinical staging system to predict the survival of EMP patients and to design individualized treatment. Instead, clinicians have chosen to use the multiple myeloma (MM) staging system. Methods Forty-eight EMP patients treated between 1996 and 2014 were included in this study. The new ...

Screening of genes involved in interactions with intestinal epithelial cells in Cronobacter sakazakii

Cronobacter sakazakii possesses a significant ability to adhere to and invade epithelial cells in its host. However, the molecular mechanisms underlying this process are poorly understood. In the current study, the adhesive and invasive capabilities of 56 C. sakazakii strains against human epithelial cells were evaluated, and one of them was selected for construction of a mutant ...

Dietary intake and risk of rheumatoid arthritis—a cross section multicenter study

Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be an established risk factor for RA. Data regarding the impact of diet on risk of RA development is limited. This study assessed the impact of dietary patterns on RA susceptibility in Chinese populations. This was a large scale, ...

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis

Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35. To study the role of Cdk5/p35 in podocyte survival, we first applied western blotting (WB) analysis to confirm the time-course expression of Cdk5 and p35 during kidney development ...

Characteristics of coronary arterial lesions in patients with coronary heart disease and hypertension

Objective The aim of this study was to investigate the correlations between risk factors such as hypertension and the complex degrees of coronary arterial lesions (CAL). Methods We selected 462 patients with coronary heart disease (CHD) with confirmed the stenosis (≥50 %) in at least one major coronary artery on coronary angiography and divided them into the “CHD with hypertension” ...

Sedimentary characteristics and processes of the Paleogene Dainan Formation in the Gaoyou Depression, North Jiangsu Basin, eastern China

In this paper, the type, vertical evolution, and distribution pattern of sedimentary facies of the Paleogene Dainan Formation in the Gaoyou Depression of the North Jiangsu Basin are studied in detail. Results show that fan delta, delta, nearshore subaqueous fan, and lacustrine facies developed during the Dainan Formation period and their distribution pattern was mainly controlled ...

Incidence and age and gender profiles of hyperplasia in individual cervical vertebrae

Objective To analyze the incidence and age and gender profiles of hyperplasia in individual cervical vertebrae.

Evidence for maternal control of seed size in maize from phenotypic and transcriptional analysis

Seed size is an important component of grain yield and a key determinant trait for crop domestication. The Krug Yellow Dent long-term selection experiment for large and small seed provides a valuable resource to dissect genetic and phenotypic changes affecting seed size within a common genetic background. In this study, inbred lines derived from Krug Large Seed (KLS) and Krug Small ...

Overexpression of the NDR1/HIN1-Like Gene NHL6 Modifies Seed Germination in Response to Abscisic Acid and Abiotic Stresses in Arabidopsis

NHL (NDR1/HIN1-like) genes play crucial roles in pathogen induced plant responses to biotic stress. Here, we report the possible function of NHL6 in plant response to abscisic acid (ABA) and abiotic stress. NHL6 was highly expressed in non-germinated seeds, and its expression was strongly induced by ABA and multiple abiotic stress signals. Loss-of-function of NHL6 decreased ...

Circulating Level of Neutrophil Extracellular Traps Is Not a Useful Biomarker for Assessing Disease Activity in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening disorders, and frequently affects the kidneys. This study investigated whether the circulating neutrophil extracellular traps (NETs) levels were associated with disease activity of AAV. We collected serum samples from 34 patients with AAV in active stage and 62 patients with AAV in ...