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The Asymmetric Effect of Bankruptcy Fraud in Sweden: A Long-Term Perspective

ObjectivesThe knowledge of the effects of white-collar crimes is incomplete. In the article, we operationalize white-collar crimes as bankruptcy frauds. Economic models maintain that interlinkages between firms may give ‘domino effects’: bankruptcy events could lead to ‘bankruptcy chains’ in which a bankruptcy spreads to other firms. Analogously, criminologists assert that social...

Destructive entrepreneurship in the small business sector: bankruptcy fraud in Sweden, 1830–2010

Entrepreneurship will not always productive: Baumol (1990, 1993) distinguishes between productive, unproductive, and destructive entrepreneurial activities, and in the last two cases, new values are not created. Setting of from the notion of destructive entrepreneurship and the bankruptcy institute as framework for the empirical analysis, we use long aggregate series on...

Comparison of segmental spinal movement control in adolescents with and without idiopathic scoliosis using modified pressure biofeedback unit

Background Postural rehabilitation emphasizing on motor control training of segmental spinal movements has been proposed to effectively reduce the scoliotic spinal deformities in adolescent idiopathic scoliosis (AIS). However, information regarding the impairments of segmental spinal movement control involving segmental spinal stabilizers in adolescent idiopathic scoliosis...

A Method for Finding Metabolic Pathways Using Atomic Group Tracking

A fundamental computational problem in metabolic engineering is to find pathways between compounds. Pathfinding methods using atom tracking have been widely used to find biochemically relevant pathways. However, these methods require the user to define the atoms to be tracked. This may lead to failing to predict the pathways that do not conserve the user-defined atoms. In this...

Aligning Metabolic Pathways Exploiting Binary Relation of Reactions

Metabolic pathway alignment has been widely used to find one-to-one and/or one-to-many reaction mappings to identify the alternative pathways that have similar functions through different sets of reactions, which has important applications in reconstructing phylogeny and understanding metabolic functions. The existing alignment methods exhaustively search reaction sets, which may...

Evaluation of surgical anti-adhesion products to reduce postsurgical intra-abdominal adhesion formation in a rat model

Background Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model...

Distinctive Effects of Cytochalasin B in Chick Primary Myoblasts and Fibroblasts

Actin-based structures play fundamental roles in cellular functions. However it remains controversial how cells cope with the absence of F-actin structures. This report focuses on short- and long-term effects of cytochalasin B (CB) on actin-complexes in fibroblasts and myoblasts. Thirty min of CB treatment dispersed subplasma actin cortices, lamellipodia, ruffled membranes...

Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis

Objective Rheumatoid arthritis (RA) is a complex autoimmune disease. Using a gene-based association research strategy, the present study aims to detect unknown susceptibility to RA and to address the ethnic differences in genetic susceptibility to RA between European and Asian populations. Methods Gene-based association analyses were performed with KGG 2.5 by using publicly...

Diagnostic Accuracy of NT-ProBNP for Heart Failure with Sepsis in Patients Younger than 18 Years

This clinical study investigated plasma NT-proBNP levels as a potential predictor of heart failure in pediatric patients with sepsis. Plasma NT-ProBNP levels of 211 pediatric patients with sepsis and 126 healthy children were measured. Patients were stratified as with heart failure (HF) or without heart failure (non-HF). Patients were graded as having sepsis, severe sepsis, or...

Characteristics of Differently Located Colorectal Cancers Support Proximal and Distal Classification: A Population-Based Study of 57,847 Patients

Background It has been suggested that colorectal cancer be regarded as several subgroups defined according to tumor location rather than as a single entity. The current study aimed to identify the most useful method for grouping colorectal cancer by tumor location according to both baseline and survival characteristics. Methods Cases of pathologically confirmed colorectal...

Decadal change of the East Asian summer monsoon and its related surface temperature in Asia-Pacific during 1880–2004

The East Asian summer monsoon (EASM) and its related change of surface temperature in the past century were not clearly addressed due to absence of atmospheric reanalysis data before 1948. On the benchmark of station-observed sea level pressure (SLP) in China, we utilized multiple SLP datasets and evaluated their qualities in measuring the SLP-based EASM index (EASMI). It is...

Global and China temperature changes associated with the inter-decadal variations of East Asian summer monsoon advances

The modern atmospheric observation and literatural historical drought-flood records were used to extract the inter-decadal signals of dry-wet modes in eastern China and reveal the possible relationship of global and China temperature changes associated with the East Asian summer monsoon advances. A climate pattern of “wet-north and dry-south” in eastern China and cool period in...

Identification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip

. Authors’ contributions Yan Qi conducted the experiments, analyzed the data and drafted the manuscript. Wen-Jie Zhang, Xiang-Lin Yuan and Feng Li designed the experiments and revised it critically for ... (2013ZRKXJQ05). We thank Dr. Wen-Jie Zhang, professor Xiang-Lin Yuan and Feng Li for their assistance in guiding us through the computational analyses and for their general support. 1. Trautmann M , Sievers E

Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7

T47D and MCF7 are two human hormone-dependent breast cancer cell lines which are widely used as experimental models for in vitro and in vivo (tumor xenografts) breast cancer studies. Several proteins involved in cancer development were identified in these cell lines by proteomic analyses. Although these studies reported the proteomic profiles of each cell line, until now, their...

Performance modeling and optimization of sparse matrix-vector multiplication on NVIDIA CUDA platform

In this article, we discuss the performance modeling and optimization of Sparse Matrix-Vector Multiplication ( ) on NVIDIA GPUs using CUDA. has a very low computation-data ratio and its performance is mainly bound by the memory bandwidth. We propose optimization of based on ELLPACK from two aspects: (1) enhanced performance for the dense vector by reducing cache misses, and (2...

Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities

Endophytes of medicinal plants have the capacity to synthesis same or similar active substances with their hosts. To investigate the diversity and capacity to produce saponins of endophytic fungi of Panax ginseng, thirty-eight strains of were isolated. Polymerase chain reaction (PCR) and sequencing were used to identify the isolates, and saponins concentrations in the cultures...

Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis

β-amyloid hypothesis is the predominant hypothesis in the study of pathogenesis of Alzheimer's disease. This hypothesis claims that aggregation and neurotoxic effects of amyloid β (Aβ) is the common pathway in a variety of etiological factors for Alzheimer's disease. Aβ peptide derives from amyloid precursor protein (APP). β-sheet breaker peptides can directly prevent and reverse...

Dissecting the Molecular Mechanism of Ionizing Radiation-Induced Tissue Damage in the Feather Follicle

Ionizing radiation (IR) is a common therapeutic agent in cancer therapy. It damages normal tissue and causes side effects including dermatitis and mucositis. Here we use the feather follicle as a model to investigate the mechanism of IR-induced tissue damage, because any perturbation of feather growth will be clearly recorded in its regular yet complex morphology. We find that IR...

Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs

Mesenchymal stem cells (MSCs) have been accepted as a promising cell source in tissue repair and regeneration. However, the inability to enrich MSCs in target areas limits their wide application. As a result, it has been a major goal to induce MSCs to be abundantly and specifically recruited to the injury site. In this study, a peptide with a specific affinity for MSCs (E7...

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis, is subject to metabolic regulation. The human muscle isozyme is significantly more sensitive towards the allosteric inhibitor, AMP, than the liver isoform. Here we report crystal structures and kinetic studies for wild-type human muscle Fru-1,6-Pase, the AMP-bound (1.6 Å), and product-bound complexes of the Q32R mutant...