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Screening novel stress granule regulators from a natural compound library

.-J. Chen was supported by the Excellent Postdoctoral fellowship from the Tsinghua-Peking Joint Center for Life Sciences. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao and Yong-Bin Yan declare no conflict ... experiments. LDH, XJC, and YBY analyzed the data. LDH and YBY wrote the paper. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan& OPEN ACCESS This article is distributed under the terms of the Creative

Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases

Cytoplasmic dynein is the most important molecular motor driving the movement of a wide range of cargoes towards the minus ends of microtubules. As a molecular motor protein, dynein performs a variety of basic cellular functions including organelle transport and centrosome assembly. In the nervous system, dynein has been demonstrated to be responsible for axonal retrograde ...

RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat

In this study, a universal protein expression enhancement RNA tool, termed RNAe, was developed by modifying a recently discovered natural long non-coding RNA. At the moment, RNAe is the only technology for gene expression enhancement, as opposed to silencing, at the post-transcriptional level. With this technology, an expression enhancement of 50–1000% is achievable, with more than ...