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[18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice

Purpose The association of Zika virus (ZIKV) infection and development of neurological sequelae require a better understanding of the pathogenic mechanisms causing severe disease. The purpose of this study was to evaluate the ability and sensitivity of positron emission tomography (PET) imaging using [18F]DPA-714, a translocator protein (TSPO) 18 kDa radioligand, to detect and...

Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporter

Drosophila neurexin (DNRX) plays a critical role in proper architecture development and synaptic function in vivo. However, the temporal and spatial expression pattern of DNRX still remains unclear. For this study, we generated a novel Drosophila transgenic strain termed the DNRX-Gal4 transgenic line, with characteristic features in agreement with the endogenous DNRX expression...

Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection

. Investigation: Emma L. Mohr, Lindsey N. Block, Christina M. Newman, Laurel M. Stewart, Michelle Koenig, Matthew Semler, Meghan E. Breitbach, Leandro B. C. Teixeira, Xiankun Zeng, Andrea M. Weiler, Gabrielle L ... : Lindsey N. Block, Christina M. Newman, Laurel M. Stewart, Michelle Koenig, Matthew Semler, Meghan E. Breitbach, Leandro B. C. Teixeira, Xiankun Zeng, Andrea M. Weiler, Gabrielle L. Barry, Gregory J. Wiepz

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

The Unfolded Protein Response of the endoplasmic reticulum (UPRER) controls proteostasis by adjusting the protein folding capacity of the ER to environmental and cell-intrinsic conditions. In metazoans, loss of proteostasis results in degenerative and proliferative diseases and cancers. The cellular and molecular mechanisms causing these phenotypes remain poorly understood. Here...

Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis

Xiankun Zeng ( 0 Steven X. Hou ) 0 0 The Mouse Cancer Genetics Program, Frederick National Laboratory for Cancer Research, National Institutes of Health , Frederick, MD 21702 , USA SUMMARY Like the