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The association between serum vitamin D levels and renal tubular dysfunction in a general population exposed to cadmium in China

in humans. Supporting information S1 File. Questionnaire. (PDF) Author Contributions Conceptualization: Xiao Chen, Taiyi Jin. Data curation: Xiao Chen, Yan Dai, Guoying Zhu. Formal analysis: Xiao ... Chen, Zhongqiu Wang, Guoying Zhu. Funding acquisition: Xiao Chen, Zhongqiu Wang. Investigation: Xiao Chen, Yan Dai, Zhongqiu Wang, Guoying Zhu, Xiaoqiang Ding, Taiyi Jin. Methodology: Xiao Chen, Taiyi

Determination of 2,4-Dichlorophenoxyacetic acid (2,4-D) in rat serum for pharmacokinetic studies with a simple HPLC method

work was supported by the National Natural Science Foundation of China (81372959). Author Contributions Conceptualization: Xiao Chen, Xi Chen. Data curation: Xiao Chen. Formal analysis: Xiao Chen ... . Funding acquisition: Yuanyuan Li. Investigation: Xiao Chen. Methodology: Xiao Chen. Project administration: Hongling Zhang. Resources: Xiao Chen. Software: Xiao Chen. Supervision: Hongling Zhang

ECG data compression using a neural network model based on multi-objective optimization

: Bo Zhang. Funding acquisition: Bo Zhang, Jianhuang Wu. Investigation: Bo Zhang. Methodology: Jianhuang Wu. Project administration: Jianhuang Wu. Resources: Jianhuang Wu. Software: Xiao Chen ... . Supervision: Jianhuang Wu. Validation: Jiasheng Zhao, Xiao Chen. Visualization: Jiasheng Zhao. Writing ± original draft: Bo Zhang, Jianhuang Wu. Writing ± review & editing: Bo Zhang, Jianhuang Wu. 14 / 16 15

Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer

Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved in the progression and metastasis of several human cancer types. However, the clinical significance and biological roles of miR-141-3p in bone metastasis of PCa are still...

Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer

Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved in the progression and metastasis of several human cancer types. However, the clinical significance and biological roles of miR-141-3p in bone metastasis of PCa are still...

Swimming characteristics of gyrotactic microorganisms in low-Reynolds-number flow: Chlamydomonas reinhardtii

The swimming characteristics of gyrotactic microorganisms are significant to understand the ecological activities in lakes, rivers and oceans. The swimming velocity of a typical motile microorganism, Chlamydomonas reinhardtii, was measured for both still water and low-Reynolds-number flow, based on a microfluidic system. Results show that the swimming speed is subject to Gaussian...

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed. CCK-8 and colony formation assay were used to investigate the cell growth. Flow cytometry analysis was used to evaluate the cell cycle and cell apoptosis. The peroxide...

Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats

Background Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseases. This study aimed to investigate the therapeutic potential of human periodontal ligament-derived stem cells (hPDLSCs) for intervention in the progress of this...

Ultrastructure and Morphology of Compound Eyes of the Scorpionfly Panorpa dubia (Insecta: Mecoptera: Panorpidae)

Mecoptera are unique in holometabolous insects in that their larvae have compound eyes. In the present study the cellular organisation and morphology of the compound eyes of adult individuals of the scorpionfly Panorpa dubia in Mecoptera were investigated by light, scanning electron, and transmission electron microscopy. The results showed that the compound eyes of adult P. dubia...

Sodium tanshinone IIA sulfonate stimulated Cl− secretion in mouse trachea

Sodium tanshinone IIA sulfonate (STS) is a derivate of tanshinone IIA, a lipophilic compound in Salvia miltiorrhiza. This study aimed to investigate the effect of STS on ion transport in mouse tracheal epithelium and the mechanisms underlying it. Short-circuit current (Isc) was measured to evaluate the effect of STS on transepithelial ion transport. Intracellular Ca2+ imaging was...

The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

Background With the increased use of neoadjuvant chemotherapy (NAC) in breast cancer, the timing of sentinel lymph node biopsy (SLNB) has become increasingly important. In this study, we aimed to evaluate the feasibility and accuracy of SLNB for initially clinically node-negative breast cancer after NAC by conducting a systematic review and meta-analysis. Methods We searched...

OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines

OGEE is an Online GEne Essentiality database. To enhance our understanding of the essentiality of genes, in OGEE we collected experimentally tested essential and non-essential genes, as well as associated gene properties known to contribute to gene essentiality. We focus on large-scale experiments, and complement our data with text-mining results. We organized tested genes into...

Managed honeybee colony losses of the Eastern honeybee (Apis cerana) in China (2011–2014)

Colony losses of managed honeybees have raised a major concern, and surveys of colony losses were conducted around the globe to understand the apicultural situation. Up to now, most studies have focused on the mortality of the Western honeybee (Apis mellifera); however, little is known about the mortality of its eastern counterpart—the Eastern honeybee (Apis cerana). Here, we...

Integrability of orbifold ABJM theories

Integrable structure has played a very important role in the study of various non-perturbative aspects of planar Aharony-Bergman-Jafferis-Maldacena (ABJM) theories. In this paper, we showed that this remarkable structure survives after orbifold operation with discrete group Γ < SU(4) R × U(1) b . For general Γ(≃ ℤ n ), we prove the integrability in the scalar sector at the planar...

Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila

Genomic distribution of the nucleosome, the basic unit of chromatin, contains important epigenetic information. To map nucleosome distribution in structurally and functionally differentiated micronucleus (MIC) and macronucleus (MAC) of the ciliate Tetrahymena thermophila, we have purified MIC and MAC and performed micrococcal nuclease (MNase) digestion as well as hydroxyl radical...

Upregulation of the proto-oncogene Bmi-1 predicts a poor prognosis in pediatric acute lymphoblastic leukemia

Background Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the prognosis of pediatric patients with acute lymphoblastic leukemia (ALL) has not been well studied. Methods The Bmi-1 expression levels in the bone marrow of 104...

Accelerated two-dimensional cine DENSE cardiovascular magnetic resonance using compressed sensing and parallel imaging

Background Cine Displacement Encoding with Stimulated Echoes (DENSE) provides accurate quantitative imaging of cardiac mechanics with rapid displacement and strain analysis; however, image acquisition times are relatively long. Compressed sensing (CS) with parallel imaging (PI) can generally provide high-quality images recovered from data sampled below the Nyquist rate. The...

Acupuncture for osteoporosis: a systematic review protocol

analysis Selection of studies All the studied presupposed criteria will be selected and identified by the three authors (Taipin Guo, Xiao Chen, and Bowen Zhu). With the identification of title and abstract

The chinese version of achilles tendon total rupture score: cross-cultural adaptation, reliability and validity

Background The Achilles tendon Total Rupture Score (ATRS), which is originally developed in 2007 in Swedish, is the only patient-reported outcome measure (PROM) for specific outcome assessment of an Achilles tendon rupture.Purpose of this study is to translate and cross-culturally adapt Achilles tendon Total Rupture Score (ATRS) into simplified Chinese, and primarily evaluate the...

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

Background Impaired myocardial perfusion reserve (MPR) is prevalent in obesity and diabetes, even in the absence of obstructive coronary artery disease (CAD), and is prognostic of adverse events. We sought to establish the time course of reduced MPR and to investigate associated vascular and tissue properties in mice fed a high-fat diet (HFD), as they are an emerging model of...