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13 papers found.
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OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers

, Waltham, 02451, MA, USA Roxana S. Redis Present address: ProQR Therapeutics N.V., 2333 CK, Leiden, The Netherlands Paloma del C. Monroig-Bosque, Maitri Y. Shah and Xiao Fu contributed equally ... . AffiliationsDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAPaloma del C. Monroig-Bosque, Maitri Y. Shah, Xiao Fu, Enrique Fuentes-Mattei, Hui Ling, Nazila

A novel and efficient fungal delignification strategy based on versatile peroxidase for lignocellulose bioconversion

The selective lignin-degrading white-rot fungi are regarded to be the best lignin degraders and have been widely used for reducing the saccharification recalcitrance of lignocellulose. However, the biological delignification and conversion of lignocellulose in biorefinery is still limited. It is necessary to develop novel and more efficient bio-delignification systems...

Using proximal remote sensing in non-invasive phenotyping of invertebrates

Proximal imaging remote sensing technologies are used to phenotype and to characterize organisms based on specific external body reflectance features. These imaging technologies are gaining interest and becoming more widely used and applied in ecological, systematic, evolutionary, and physiological studies of plants and also of animals. However, important factors may impact the...

Genetic mechanism and development of the unsteady Sarvak play of the Azadegan oil field, southwest of Iran

Fu 0 1 0 Iraq Branch Company of CNODC, CNPC , Dubai 500486 , United Arab Emirates 1 Geology and Exploration Research Institute, CNPC Chuanqing Drilling Engineering Company Limited , Chengdu 610051

A Liver-Centric Multiscale Modeling Framework for Xenobiotics

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of...

Placement of a modified cannula in the innominate vein for sufficient drainage during the bidirectional Glenn shunt procedure without cardiopulmonary bypass

During the bidirectional Glenn shunt procedure in small infants, the standard right-angle venous cannula is frequently placed in the innominate vein for establishing the temporary veno-atrial bypass without cardiopulmonary bypass, but it should be small enough to allow flow to pass around it from the internal jugular vein opposite to the side the cannula is directed. Small...

Induction of Murine Macrophage M2 Polarization by Cigarette Smoke Extract via the JAK2/STAT3 Pathway

Cigarette smoking is a major pathogenic factor in lung cancer. Macrophages play an important role in host defense and adaptive immunity. These cells display diverse phenotypes for performing different functions. M2 type macrophages usually exhibit immunosuppressive and tumor-promoting characteristics. Although macrophage polarization toward the M2 phenotype has been observed in...

Total arch repair for acute type A aortic dissection with open placement of a modified triple-branched stent graft and the arch open technique

Background In total arch repair with open placement of a triple-branched stent graft for acute type A aortic dissection, the diameters of the native arch vessels and the distances between 2 neighboring arch vessels did not always match the available sizes of the triple-branched stent grafts, and insertion of the triple-branched stent graft through the distal ascending aortic...

Expression of RNA-Interference/Antisense Transgenes by the Cognate Promoters of Target Genes Is a Better Gene-Silencing Strategy to Study Gene Functions in Rice

Antisense and RNA interference (RNAi)-mediated gene silencing systems are powerful reverse genetic methods for studying gene function. Most RNAi and antisense experiments used constitutive promoters to drive the expression of RNAi/antisense transgenes; however, several reports showed that constitutive promoters were not expressed in all cell types in cereal plants, suggesting...

PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation

Autosomal dominant polycystic liver disease (PCLD) is caused by mutations of either PRKCSH or Sec63, two proteins associated with the endoplasmic reticulum (ER). Both proteins are involved in carbohydrate processing, folding and translocation of newly synthesized glycoproteins. It is postulated that defective quality control of proteins initiates endoplasmic reticulum-associated...

A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis

Mutations of the immunoglobulin superfamily proteins nephrin and Neph1 lead to congenital nephrotic syndrome in humans or mice. Neph proteins are three closely related molecules that are evolutionarily conserved and mediate cell recognition. Their importance for morphogenetic processes including the formation of the kidney filtration barrier in vertebrates and synaptogenesis in...

Association of Serum and Follicular Fluid Leptin Concentrations with Granulosa Cell Phosphorylated Signal Transducer and Activator of Transcription 3 Expression in Fertile Patients with Polycystic Ovarian Syndrome

Objective: Our objective was to evaluate whether polycystic ovarian syndrome (PCOS)-associated infertility is related to alterations of leptin, leptin receptor (Ob-R), and the phosphorylated signal transducer and activator of transcription 3 (p-STAT3)/suppressor of cytokine signal 3 (SOCS3) system in the ovary.

Regulatory Role of Interleukin-10 and Interferon-γ in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected with Schistosoma japonicum

Background. Schistosoma japonicum is the most pathogenic agent of hepatosplenic schistosomiasis. It causes fibrosis of the central (CentF) and peripheral (PerF) portal areas. We investigated whether CentF and PerF in Chinese fishermen infected with S. japonicum were associated with an abnormal production of cytokines and chemokines that, in experimental models, have been...