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Dynamic and static performance optimization of dual active bridge DC-DC converters

power devices . Xiao SUN was born in Dezhou, Shangdong, China, in 1991, received the B.S. degree and M.S degree in electrical engineering from Southwest Jiaotong University, Chengdu, China, in 2014 and

Text feature extraction based on deep learning: a review

Selection of text feature item is a basic and important matter for text mining and information retrieval. Traditional methods of feature extraction require handcrafted features. To hand-design, an effective feature is a lengthy process, but aiming at new applications, deep learning enables to acquire new effective feature representation from training data. As a new feature...

Efficient identification of SNPs in pooled DNA samples using a dual mononucleotide addition-based sequencing method

Identifying single nucleotide polymorphism (SNPs) from pooled samples is critical for many studies and applications. SNPs determined by next-generation sequencing results may suffer from errors in both base calling and read mapping. Taking advantage of dual mononucleotide addition-based pyrosequencing, we present Epds, a method to efficiently identify SNPs from pooled DNA samples...

DNABP: Identification of DNA-Binding Proteins Based on Feature Selection Using a Random Forest and Predicting Binding Residues

DNA-binding proteins are fundamentally important in cellular processes. Several computational-based methods have been developed to improve the prediction of DNA-binding proteins in previous years. However, insufficient work has been done on the prediction of DNA-binding proteins from protein sequence information. In this paper, a novel predictor, DNABP (DNA-binding proteins), was...

Combinatorial pooled sequencing: experiment design and decoding

ETHICS GUDELINES The authors Chang-chang Cao and Xiao Sun declare no competing financial interests. This article does not contain any studies with human or animal subjects performed by any of the authors

The remanence ratio in CoFe2O4 nanoparticles with approximate single-domain sizes

Approximately single-domain-sized 9-, 13-, and 16-nm CoFe2O4 nanoparticles are synthesized using the thermal decomposition of a metal-organic salt. By means of dilution and reduction, the concentration, moment, and anisotropy of nanoparticles are changed and their influence on the magnetic properties is investigated. The relation of M r/M s ∝ 1/lgH dip is observed, where M r/M s...

An accurate clone-based haplotyping method by overlapping pool sequencing

Chromosome-long haplotyping of human genomes is important to identify genetic variants with differing gene expression, in human evolution studies, clinical diagnosis, and other biological and medical fields. Although several methods have realized haplotyping based on sequencing technologies or population statistics, accuracy and cost are factors that prohibit their wide use...

DectICO: an alignment-free supervised metagenomic classification method based on feature extraction and dynamic selection

Xiao Sun 0 0 State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096 , China Background: Continual progress in next

Comparison of the experimental methods in haplotype sequencing via next generation sequencing

), and the National Natural Science Foundation of China (Nos. 61227803 and 61571121). COMPLIANCE WITH ETHICS GUIDELINES The authors Jing Tu, Na Lu, Mengqin Duan, An Ju, Xiao Sun and Zuhong Lu declare they

Released micromachined beams utilizing laterally uniform porosity porous silicon

Suspended micromachined porous silicon beams with laterally uniform porosity are reported, which have been fabricated using standard photolithography processes designed for compatibility with complementary metal-oxide-semiconductor (CMOS) processes. Anodization, annealing, reactive ion etching, repeated photolithography, lift off and electropolishing processes were used to...

Quantitative group testing-based overlapping pool sequencing to identify rare variant carriers

Background Genome-wide association studies have revealed that rare variants are responsible for a large portion of the heritability of some complex human diseases. This highlights the increasing importance of detecting and screening for rare variants. Although the massively parallel sequencing technologies have greatly reduced the cost of DNA sequencing, the identification of...

The cost-effectiveness analysis of JinQi Jiangtang tablets for the treatment on prediabetes: a randomized, double-blind, placebo-controlled, multicenter design

author: Xiao Sun 2 The control group 3 Dingzhi Men Hospital of Beijing University of TCM , Tianjin , China 4 Tianjin University of TCM , 9 ShuangfengStreet, Nankai District, Tianjin 300193 , China 5

Nucleosome organization in the vicinity of transcription factor binding sites in the human genome

Background The binding of transcription factors (TFs) to specific DNA sequences is an initial and crucial step of transcription. In eukaryotes, this process is highly dependent on the local chromatin state, which can be modified by recruiting chromatin remodelers. However, previous studies have focused mainly on nucleosome occupancy around the TF binding sites (TFBSs) of a few...

Rapid Identification of Major QTLs Associated with Rice Grain Weight and Their Utilization

To uncover the genetics of rice grain weight, we constructed an RIL population derived from a cross between a large grain accession M201 and a small size variety JY293. Specific Locus Amplified Fragment Sequencing (SLAF-Seq) technology was used to genotype two bulked DNA pools made from individual DNA of the heaviest 30 lines and the lightest 30 lines according to the 1000 grain...

Identification of apoptosis-related microRNAs and their target genes in myocardial infarction post-transplantation with skeletal myoblasts

Background Skeletal myoblasts (SkMs) has provided a promising treatment for myocardial infarction (MI). Functioning as posttranscriptional regulators, microRNAs (miRNAs) play important roles in cardiac repairment and stem cell regulation. However, the correlation between miRNAs and their targeted genes in SkM cell therapy for MI was not fully understood. Methods We explored the...

The Patterns of Histone Modifications in the Vicinity of Transcription Factor Binding Sites in Human Lymphoblastoid Cell Lines

Transcription factor (TF) binding at specific DNA sequences is the fundamental step in transcriptional regulation and is highly dependent on the chromatin structure context, which may be affected by specific histone modifications and variants, known as histone marks. The lack of a global binding map for hundreds of TFs means that previous studies have focused mainly on histone...

Construction and Analysis of the Model of Energy Metabolism in E. coli

Genome-scale models of metabolism have only been analyzed with the constraint-based modelling philosophy and there have been several genome-scale gene-protein-reaction models. But research on the modelling for energy metabolism of organisms just began in recent years and research on metabolic weighted complex network are rare in literature. We have made three research based on...

The nucleosome regulates the usage of polyadenylation sites in the human genome

Background It has been reported that 3' end processing is coupled to transcription and nucleosome depletion near the polyadenylation sites in many species. However, the association between nucleosome occupancy and polyadenylation site usage is still unclear. Results By systematic analysis of high-throughput sequencing datasets from the human genome, we found that nucleosome...

The effects of surface spin on magnetic properties of weak magnetic ZnLa0.02Fe1.98O4 nanoparticles

In order to prominently investigate the effects of the surface spin on the magnetic properties, the weak magnetic ZnLa0.02Fe1.98O4 nanoparticles were chosen as studying objects which benefit to reduce as possibly the effects of interparticle dipolar interaction and crystalline anisotropy energies. By annealing the undiluted and diluted ZnLa0.02Fe1.98O4 nanoparticles at different...