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CD146: a potential therapeutic target for systemic sclerosis

, Xiaofeng Zeng and Xiyun Yan designed the experiments. Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu and Fei Wang performed all the experiments, analyzed and interpreted the data, Mengtao Li, Dong Xu ... , Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng, Xiaofeng Zeng and Xiyun Yan declare that they have no conflict of interest. All procedures followed were in accordance with

Deciphering the Draft Genome of Toxoplasma gondii RH Strain

Toxoplasmosis is a widespread parasitic infection by Toxoplasma gondii, a parasite with at least three distinct clonal lineages. This article reports the whole genome sequencing and de novo assembly of T. gondii RH (type I representative strain), as well as genome-wide comparison across major T. gondii lineages. Genomic DNA was extracted from tachyzoites of T. gondii RH strain...

Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

The gaseous phytohormone ethylene participates in the regulation of root growth and development in Arabidopsis. It is known that root growth inhibition by ethylene involves auxin, which is partially mediated by the action of the WEAK ETHYLENE INSENSITIVE2/ANTHRANILATE SYNTHASE α1 (WEI2/ASA1), encoding a rate-limiting enzyme in tryptophan (Trp) biosynthesis, from which auxin is...

HDG11 upregulates cell-wall-loosening protein genes to promote root elongation in Arabidopsis

The gain-of-function mutant edt1 shows significantly enhanced drought tolerance and a well-developed root system including deeper primary roots and more lateral roots. To explore the molecular mechanisms underlying the improved root system of edt1, we performed transcriptome comparison between the wild-type and edt1 roots. One of the interesting findings from the analysis was...

MADS-Box Transcription Factor AGL21 Regulates Lateral Root Development and Responds to Multiple External and Physiological Signals

Plant root system morphology is dramatically influenced by various environmental cues. The adaptation of root system architecture to environmental constraints, which mostly depends on the formation and growth of lateral roots, is an important agronomic trait. Lateral root development is regulated by the external signals coordinating closely with intrinsic signaling pathways. MADS...