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Statistical Identification of Markov Chain on Trees

The theoretical study of continuous-time homogeneous Markov chains is usually based on a natural assumption of a known transition rate matrix (TRM). However, the TRM of a Markov chain in realistic systems might be unknown and might even need to be identified by partially observable data. Thus, an issue on how to identify the TRM of the underlying Markov chain by partially...

Fabrication and Characterization of Two-Dimensional Layered MoS2 Thin Films by Pulsed Laser Deposition

Direct growth of uniform wafer-scale two-dimensional (2D) layered materials using a universal method is of vital importance for utilizing 2D layers into practical applications. Here, we report on the structural and transport properties of large-scale few-layer MoS2 back-gated field effect transistors (FETs), fabricated using conventional pulsed laser deposition (PLD) technique...

LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation

BackgroundMesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat containing membrane protein (LRRC15) is a transmembrane protein demonstrated to play important roles in cancer. However, little is known about its role in osteogenesis...

Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

BackgroundTruncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau294–305, an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau294–305-targeted approach may have beneficial effects in the treatment of AD and FTD.MethodsIn this study, we...

Reordering Transaction Execution to Boost High-Frequency Trading Applications

DEKE, Renmin University of China , Beijing , China 1 School of Information, Renmin University of China , Beijing , China 2 & Xiao Zhang 3 School of Data Science and Engineering, East China Normal

Synchronization enhancement of indirectly coupled oscillators via periodic modulation in an optomechanical system

-Xiao Zhang & Jin-Hui Wu AuthorsSearch for Lei Du in:Nature Research journals • PubMed • Google Scholar Search for Chu-Hui Fan in:Nature Research journals • PubMed • Google Scholar Search for Han-Xiao ... Zhang in:Nature Research journals • PubMed • Google Scholar Search for Jin-Hui Wu in:Nature Research journals • PubMed • Google Scholar Contributions L. Du and J.-H. Wu conceived the idea and wrote the

The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1

The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1 Xiao Zhang,1 Peng Li,1 Zhen Ding,1 Huili Wang,1 Junye Wang,1 ... OncoTargets and Therapy The putative tumor suppressor, mir-199a, regulated by snail, modulates clear cell renal cell carcinoma aggressiveness by repressing r OcK1 Xiao Zhang 1 2 Zhen Ding 1 2 Junye

Protein deubiquitinase USP7 is required for osteogenic differentiation of human adipose-derived stem cells

Background Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases have been linked to stem cell fate determination, whether protein deubiquitination contributes to lineage commitment during osteogenic differentiation of hASCs...

Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer

Conceptualization: Ankui Yang. Data curation: Yongle Jiang, Xuan Su, Xiao Zhang, Weichao Chen, Zulu Ye, Tiancheng Deng, Wenze Deng. Formal analysis: Caiyun He, Jiangjun Ma, Xuan Su, Xiao Zhang, Tiancheng Deng

An I/O-Efficient Buffer Batch Replacement Policy for Update-Intensive Graph Databases

With the proliferation of graph-based applications, such as social network management and Web structure mining, update-intensive graph databases have become an important component of today’s data management platforms. Several techniques have been recently proposed to exploit locality on both data organization and computational model in graph databases. However, little...

An example of host plant expansion of host-specialized Aphis gossypii Glover in the field

The host plant expansion of host-specialized Aphis gossypii (Glover) has been well studied in the laboratory; however, this phenomenon is poorly understood in the field. Here, we provide a series of laboratory and field experiments to assess the role of zucchini in the host plant expansion of cotton-specialized aphids. We observed that cotton-specialized aphids possessed the...

Monitoring Chemical Changes on the Surface of Kenaf Fiber during Degumming Process Using Infrared Microspectroscopy

• PubMed • Google Scholar Search for Chengfeng Zhou in:Nature Research journals • PubMed • Google Scholar Search for Yan Song in:Nature Research journals • PubMed • Google Scholar Search for Xiao Zhang

Antioxidant Enzyme Responses Induced by Whiteflies in Tobacco Plants in Defense against Aphids: Catalase May Play a Dominant Role

Background Bemisia tabaci MEAM1 (Middle East-Asia Minor 1) feeding alters antioxidative enzyme activity in some plant species. Infestation of B. tabaci nymphs decreases Myzus persicae performance on systemic, but not local leaves of tobacco plants. However, it is unclear if B. tabaci nymphs induced antioxidant activities contributing to the aphid resistance. Methodology/Principal...

RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling

, Beijing, 100081, ChinaMin Zhang, Ping Zhang, Yunsong Liu, Longwei Lv, Xiao Zhang & Yongsheng ZhouNational Engineering Lab for Digital and Material Technology of Stomatology, Beijing Key Laboratory of ... Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100081, ChinaMin Zhang, Ping Zhang, Yunsong Liu, Longwei Lv, Xiao Zhang, Hao Liu & Yongsheng ZhouCentral Laboratory

Climate Change Detection and Annual Extreme Temperature Analysis of the Amur River Basin

This paper aims to detect climate change points and compare the extreme temperature changes with the average-value changes in the Amur River basin. The daily air temperatures of 44 stations in the Amur River basin were collected from April 1, 1954, to March 31, 2013. The change points for annual mean and extreme temperature in 44 individual stations and their average were...

Cryptanalysis and Improvement of a Biometric-Based Multi-Server Authentication and Key Agreement Scheme

With the security requirements of networks, biometrics authenticated schemes which are applied in the multi-server environment come to be more crucial and widely deployed. In this paper, we propose a novel biometric-based multi-server authentication and key agreement scheme which is based on the cryptanalysis of Mishra et al.’s scheme. The informal and formal security analysis of...

Direct medical cost associated with diabetic retinopathy severity in type 2 diabetes in Singapore

Diabetic retinopathy (DR) is a leading cause of vision-loss globally among type 2 diabetes (T2DM) patients. Information on the economic burden of DR in Singapore is limited. We aim to identify the total annual direct medical costs of DR at different stages, and to examine factors influencing the costs. Four hundreds and seventy T2DM patients who attended the Diabetes Centre in a...

A novel visual facial anxiety scale for assessing preoperative anxiety

Background There is currently no widely accepted instrument for measuring preoperative anxiety. The objective of this study was to develop a simple visual facial anxiety scale (VFAS) for assessing acute preoperative anxiety. Methods The initial VFAS was comprised of 11 similarly styled stick-figure reflecting different types of facial expressions (Fig 1). After obtaining IRB...

Association of Serum CXCL13 with Intrarenal Ectopic Lymphoid Tissue Formation in Lupus Nephritis

Xia Long performed research, interpreted data, and wrote the paper; Xiao Zhang designed research and revised the paper. References Y. Liu and H.-J. Anders, “Lupus nephritis: from pathogenesis to