administration: Suo-di Zhai. Writing ± original draft: Peng Men. Writing ± review & editing: Xiao-tong Li, Suo-di Zhai. 15 / 18 16 / 18 17 / 18 1. Ogurtsova K , da Rocha Fernandes JD , Huang Y , Linnenkamp U
Axon guidance molecule Slit is critical for the axon repulsion in neural tissues, which is evolutionarily conserved from planarians to humans. However, the function of Slit in the silkworm Bombyx mori was unknown. Here we showed that the structure of Bombyx mori Slit (BmSlit) was different from that in most other species in its C-terminal sequence. BmSlit was localized in the...
Coevolution is important for the maintenance of the interaction between a ligand and its receptor during evolution. The interaction between axon guidance molecule Slit and its receptor Robo is critical for the axon repulsion in neural tissues, which is evolutionarily conserved from planarians to humans. However, the mechanism of coevolution between Slit and Robo remains unclear...
